Defining the Phenotype of Autism and Autism Spectrum Disorders. Past and Future Perspectives on Autism Epidemiology. Genetic Basis of Autism. Epigenetic Mechanisms in Autism: Methylation and Imprinting. Synapse Formation. Fear and Anxiety Pathways. Learning and Memory. Basal Ganglia and the Cerebellum. Language. Prefrontal Cortex and Executive Functions. Sensory Systems. Attention. The Neural Basis of Social Affiliative Behavior. The Thalamus and Neuromodulatory Systems. Neurovirology and Other Environmental Effects. Neuroanatomy, Neuropathology, and Neurochemistry. Neuroimaging. Neuropsychology and Neurophysiology. Neurobiology of Related Disorders: Tuberous Sclerosis and Fragile X Syndrome. Pharmacogenomics and Drug Discovery. Advocacy and Promoting Research. Social Economics of Autism. Sciencewatch on Autism-Book Summary.
Steven O. Moldin, John L R Rubenstein
"…the chapter 'Past and Future Perspectives on Autism's
Epidemiology' by Eric Fombonne is noteworthy. Reviewing studies
published in 14 countries, Fombonne makes clear the daunting task
of determining such fundamentals as the definition and incidence of
autism…This is an important book for anyone engaged in the care of
autistic individuals or in research in the area, but should also
interest anyone whose clinical or research interests touch on any
aspect of the neurobiology of behavior."
-Ronald J. Friedman, in PsycCRITIQUES, Vol. 52, No. 12, March
2007
"... This volume lays a fine foundation for those in and outside
autism, expertly reviewing what is currently known on specific
topics, while also bringing authors with relevant perspectives who
have not previously addressed ASD. By bringing basic neuroscience
concepts and modeling together with clinical autism experts, this
book serves as a forum for the multidisciplinary crossfertilization
that is needed for the next decade of advances."
-Emanuel DiCicco-Bloom Department of Neuroscience and Cell
Biology/Pediatrics Robert Wood Johnson Medical School in Neuron 54,
April 2007"This book provides outstanding updates in diagnosis,
epidemiology, genetics and genomics, neuroanatomy, neurophysiology,
neuropsychology, and the neural systems underlying the inherent
behavioral aspects of autism…a seminal work that makes a highly
important contribution to the field of autism research."
—Pauline A. Filipek, M.D. in the New England Journal of Medicine,
April 2007
"A variety of illnesses comprise autism spectrum disorders and
collectively represent a major medical problem. One can predict
that this authoritative collection of essays, representing almost
all of the leading workers in this important and growing field of
research, will move autism research into a rightfully prominent
place in modern medicine."
—Paul Greengard, Ph.D., Nobel Laureate, Rockefeller University, New
York City
"A 500-page guide for the march toward a cure for autism. This
penetrating overview of cutting-edge neuroscience research and
treatment will be invaluable in motivating scientists to study
autism, raising public awareness and giving hope to those families
who suffer from this devastating disorder."
—Suzanne and Bob Wright, Founders, Autism Speaks, New York City
"Moldin and Rubenstein, themselves experts in genetics and
developmental neurobiology, have brought together, for the first
time, the very best and most creative thinkers in the field. This
book, long overdue, is the essential survey and summary of the
tremendous advances the last ten years have brought in autism
neuroscience. It also serves as a sobering reminder of the
hardships that still await families and scientists as they struggle
to deal with autism at home and in the lab."
—Jonathan Shestack, Co-founder, Cure Autism Now, Los Angeles
"This excellent collection of chapters on ASD, and on basic
research relevant to ASD, provides few answers, but, I fear, better
reflects the truth about our understanding of autism. A detailed
and thorough examination of epidemiological studies by Eric
Fombonne, for example, casts real doubt on the claim that the rate
of ASD cases is increasing…And if there is no big rise in
prevalence, there is no need to invoke a major environmental
contribution. …Similarly, the idea that autism can be explained by
damage to the limbic system (the 'social brain') is probably too
simplistic. …Indeed, many examples in the book illustrate how much
more complex the story of autism is likely to be…the book by Moldin
and Rubenstein gives as much reason for hope as for despair. The
chapters reflect the diverse tools being called into the service of
understanding autism, including neuroimaging, animal models, even
the use of neurotropic viruses, which attack the nervous system, to
trace chains of synaptically linked neurons."
—Francesca Happé, Institute of Psychiatry, King's College London,
for NATURE, August 2006
"A variety of illnesses comprise autism spectrum disorders and
collectively represent a major medical problem. One can predict
that this authoritative collection of essays, representing almost
all of the leading workers in this important and growing field of
research, will move autism research into a rightfully prominent
place in modern medicine."
—Paul Greengard, Ph.D., Nobel Laureate, Rockefeller University, New
York City
"A 500-page guide for the march toward a cure for autism. This
penetrating overview of cutting-edge neuroscience research and
treatment will be invaluable in motivating scientists to study
autism, raising public awareness and giving hope to those families
who suffer from this devastating disorder."
—Suzanne and Bob Wright, Founders, Autism Speaks, New York City
"Moldin and Rubenstein, themselves experts in genetics and
developmental neurobiology, have brought together, for the first
time, the very best and most creative thinkers in the field. This
book, long overdue, is the essential survey and summary of the
tremendous advances the last ten years have brought in autism
neuroscience. It also serves as a sobering reminder of the
hardships that still await families and scientists as they struggle
to deal with autism at home and in the lab."
n and Rubenstein, themselves experts in genetics and developmental
neurobiology, have brought together, for the first time, the very
best and most creative thinkers in the field. This book, long
overdue, is the essential survey and summary of the tremendous
advances the last ten years have brought in autism neuroscience. It
also serves as a sobering reminder of the hardships that still
await families and scientists as they struggle to deal with autism
at home and in the lab."—Jonathan Shestack, Co-founder, Cure Autism
Now, Los Angeles"Overall, this book is written very clearly and
concisely and widely covers the most important key findings of
research on autism and ASD. All chapters are written in a lucid way
and a complete set of references is given at the end of each
section. In addition, this is the first book combining all current
autism research carried out to date… This book will be a valuable
resource for clinical and basic scientists as well as for students
and parents to want to know more about (the underlying aspects of)
autism and ASD."—Elsevier’s Journal of Chemical Neuroanatomy, March
2008"… this book is written very clearly and concisely and widely
covers the most important key findings of research on autism and
ASD. … this is the first book combining all current autism research
carried out to date … . This book will be a valuable resource for
clinical and basic scientists as well as for students and parents …
."— Imke van Kooten, School for Mental Health and Neurosciences,
Division of Cellular Neuroscience, Maastricht University,
Maastricht, The Netherlands in Journal of Chemical Neuroanatomy
Vol. 36, 2008
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