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Presents the principles underlying molecular medicine as related to neurology

Table of Contents

PREFACE – Stephen G. Waxman

Section I. Principles of Molecular Neurology.
Genetics as a Tool in Neurology.
Neurology and Genomic Medicine.
Mitochondrial Function and Dysfunction in the Nervous System.
Neuronal Channels and Receptors.
Protein Misfolding, Chaperone Networks, and the Heat Shock Response
in the Nervous System.
Metabolic Biopsy of the Brain.
Gene therapy approaches in neurology.
Programmed Cell Death and its Role in Neurological Disease.

Section II. Disorders of Development.
Developmental Neurology: A Molecular Perspective.
Metabolic Diseases of the Nervous System.
Genetic Disorders of Neuromuscular Development.

Section III. Stroke and Trauma.
Molecular Mechanisms of Ischemic Brain Disease.
Hemorrhagic Brain Disease.
The Dawn of Molecular and Cellular Therapies for Traumatic Spinal Cord Injury.

Section IV. Degenerative Diseases.
Parkinson’s Disease: Molecular Insights.
The molecular basis of Alzheimer’s disease.
Polyglutamine Disorders including Huntington’s Disease.
Friedreich’s Ataxia and Related RNA Loss-Of-Function Disorders.
DYT1, a Primary Torsion Dystonia.
Motor Neuron Disease: Amyotrophic Lateral Sclerosis.
Genetic Disorders of the Autonomic Nervous System.
Multiple sclerosis as a neurodegenerative disease.

Section V. Disorders of Excitation and Transmission.
Acquired Epilepsy: Cellular and Molecular Mechanisms.
Genetic Epilepsies.
Tourette’s Syndrome.

Section VI. Disorders of Sleep and Circadian Rhythms.

Disorders of Sleep and Circadian Rhythms.

Section VII. Pain
Cronic pain as a molecular disorder.
Migraine as a cerebral ionopathy with impaired central sensory processing.

Section VIII. Peripheral Nerve Disease.
Dysmyelinating and Demyelinating Disorders of the PNS, or Inherited Neuropathies.

Section IX. Neuro-Immunology.
Demyelinating Diseases: Immunological Mechanisms in the Pathogenesis of Multiple Sclerosis.
Molecular Neurology: Autoimmune disorders of the neuromuscular junction and motor nerve terminal.
Paraneoplastic Neurologic Syndromes.
Mitochondrial Disorders.

Section X. Infectious Disorders.
Molecular Neurology of HIV-1 Infection and AIDs.