Medical textbook that offers uniquely broad coverage of the molecular basis of major human diseases in the context of traditional pathology, with implications for translational molecular medicine.
PART I: Essential Pathology - Mechanisms of Disease Molecular Mechanisms of Cell Death Acute and Chronic Inflammation Infection and Host Response Neoplasia PART II: Concepts in Molecular Biology and Genetics Basic Concepts in Human Molecular Genetics The Human Genome: Implications for the Understanding of Human Disease The Human Transcriptome: Implications for the Understanding of Human Disease The Human Epigenome: Implications for the Understanding of Human Disease The Human Proteome: Implications for the Understanding of Human Disease Integrative Systems Biology: Implications for the Understanding of Human Disease PART III:Principles and Practice of Molecular Pathology Pathology: The Clinical Description of Human Disease Molecular Pathogenesis: The Biological Basis of Human Disease Integration of Molecular and Cellular Pathogenesis PART IV: Molecular Pathology of Human Disease Molecular Basis of Cardiovascular Disease Molecular Basis of Hemostatic and Thrombotic Diseases Molecular Basis of Lymphoid and Myeloid Diseases Molecular Basis of Diseases of Immunity Molecular Basis of Pulmonary Disease Molecular Basis of Diseases of the Gastrointestinal Tract Molecular Basis of Liver Disease Molecular Basis of Diseases of the Exocrine Pancreas Molecular Basis of Diseases of the Endocrine System Molecular Basis of Gynecologic Diseases Molecular Basis of Prostate Disease Molecular Basis of Breast Disease Molecular Basis of Skin Disease Molecular Basis of Diseases of the Nervous System PART V: Practice of Molecular Medicine Molecular Diagnosis of Human Disease Molecular Assessment of Human Disease in the Clinical Laboratory Pharmacogenomics and Personalized Medicine in the Treatment of Human Disease
William B. Coleman, PhD is Professor of Pathology and Laboratory Medicine and Director of Graduate Studies for the Molecular and Cellular Pathology Graduate Program at the University of North Carolina School of Medicine (Chapel Hill, NC). Dr. Coleman is co-director of the UNC Program in Translational Medicine, and co-director of the Environmental Pathology Predoctoral and Postdoctoral Training Program. In addition, he is affiliated with the Curriculum in Toxicology and is a member of the UNC Lineberger Comprehensive Cancer Center. Dr. Coleman is actively involved in teaching biomedical graduate students and is a three-time recipient of the Joe W. Grisham Award for Excellence in Graduate Student Teaching from the Molecular and Cellular Pathology graduate students at UNC-Chapel Hill. Dr. Coleman is active in the leadership of the American Society for Investigative Pathology, and is a member of the American Association for Cancer Research. He serves on the editorial boards of Clinica Chimica Acta, The American Journal of Pathology, Experimental and Molecular Pathology, Archives of Pathology and Laboratory Medicine, and Laboratory Investigation, and has served as an ad hoc reviewer for 48 other journals. Dr. Coleman's major research interests are in the molecular pathogenesis of human cancers, with a specific interest in breast cancer epigenetics, liver carcinogenesis, and lung cancer biology. His research has been funded by the NIH/NCI, The Susan G. Komen Breast Cancer Foundation, Friends for an Earlier Breast Cancer Test, and the UNC Lineberger Comprehensive Cancer Center. Dr. Coleman is the author of over 100 original research articles, reviews, and book chapters. In addition, Dr. Coleman has co-edited or co-authored six books on topics related to molecular pathology, molecular diagnostics, and the molecular pathogenesis of human cancer. Gregory J. Tsongalis, Ph.D., H.C.L.D., C.C. is Professor of Pathology, Director, Molecular Pathology, and Co-Director Translational Research Program, Department of Pathology, Dartmouth Hitchcock Medical Center and The Audrey and Theodor Geisel School of Medicine at Dartmouth, Lebanon, NH, USA
"The editors of Molecular Pathology have produced a comprehensive compendium of the state-of-the-art in molecular pathogenesis, an impressive accomplishment given the diverse cells and organ systems involved in human disease. An established cadre of experts has contributed to this first, well-designed edition. As a result, essential topics ranging from cell injury/death, the molecular basis of cardiovascular diseases and disorders of the nervous system, and modern molecular diagnostics are amply addressed. In a rapidly emerging discipline, it is challenging to capture the details that define the field. Molecular Pathology has accomplished this goal in an outstanding manner and will serve as an excellent resource for those already established in clinical care and biomedical research, for those who seek to maintain competency in molecular pathology, as well as for all students involved in interdisciplinary studies related to human disease or modern clinical investigations." --Linda M. McManus, PhD, Professor, University of Texas Health Science Center at San Antonio "The focus of Molecular Pathology is genetic and molecular but it has been written to enhance the work of an active pathologist, clearly describing the basics as well as providing ample sampling of the molecular complexities of disease. Gladly the editors did not assemble an exhaustive compendium of facts and details that would inevitably become obsolete in short order. Instead, the contributors concentrated on clarity of explanation supported by selected examples so that the reader may grasp the fundamentals better. In fact, this may be one medical textbook that can be read cover-to-cover without being lost in details. The figures are clear, helpful, and plentiful which is important when dealing with so many complex technologies and concepts. I highly recommend this book." --Edison T. Liu, M.D, Executive Director, Genome Institute of Singapore
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