George Fink is a Neuroendocrinologist and Neuropharmacologist who has had a major interest in stress since the start of his career. He was recently appointed Vice President and Director of Research of the Pharmos Corporation in Israel and the United States, and is the former Director of the Medical Research Council's Brain Metabolism Unit and honorary professor in the University of Edinburgh in Scotland. Dr. Fink has published over 340 neuroendocrine papers and several authoritative books, and is past president of the European Neuroendocrine Association.

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Table of Contents

Part I: Basic Principles of Neuroendocrinology An introduction to neuroendocrine systems Signaling in neuroendocrine systems Neuroendocrine Control Systems

Part II: Neural Regulation of Endocrine Systems Evolution of Neurohormones Neural control of the anterior lobe of the pituitary gland (pars distalis) Neural control of the posterior pituitary gland (neurohypophysis) Neural Control of the Intermediate Lobe of the Pituitary Gland (Pars Intermedia) and Proopiomelanocortin THE HYPOTHALAMIC PITUITARY ADRENAL AXIS AND NEUROENDOCRINE RESPONSES TO STRESS Neuroendocrine Control of Reproduction Lifetime Regulation of Growth-Hormone (GH) Secretion NEUROENDOCRINE REGULATION OF DEVELOPMENT, GROWTH AND METABOLISM – THYROID Circadian Rhythms in Neuroendocrine Systems Cardiovascular control – renin angiotensin- AV3V – PVN

Part III: Hormones, Brain Function and Behavior Neuroendocrine Regulation of Food Intake and Energy Homeostasis Neuropeptide regulation of stress-induced behavior: insights from the CRF/Urocortin family Neuroendocrine regulation of body water and electrolytes: Thirst and salt appetite Sexual differentiation of brain and behavior Corticosteroid actions on neurotransmission Neuroendocrine Mechanism of Puberty Sexual behaviors Stress and brain function Neuroendocrinology of Aggression Chronic Social Stress: Effects on Neuroendocrine Function Estrogen and Cognitive Aging in Women: The Critical Period Hypothesis Hormones, mood and affect Hormones and the aging brain

Part IV: Neuroendocrine Pathology KALLMANN SYNDROME AND OTHER CAUSES OF HYPOTHALAMIC HYPOGONADISM AND RELATED DEVELOPMENT DISORDERS Parental Behavior and the Perinatal Programming of Infant Development Disorders of the hypothalamic-pituitary- adrenocortical system Disorders of the Hypothalamic-Pituitary-Gonadal Axis Disorders of the hypothalamic-pituitary- thyroid system Neuroendocrine growth disorders – dwarfism – gigantism Neuroendocrine inherited or induced aromatase enzyme deficits Pituitary adenomas Neuroendocrine carcinomas Psychoneuroendocrinology

About the Author

George Fink is a Neuroendocrinologist and Neuropharmacologist who has had a major interest in stress since the start of his career. He was recently appointed Vice President and Director of Research of the Pharmos Corporation in Israel and the United States, and is the former Director of the Medical Research Council's Brain Metabolism Unit and honorary professor in the University of Edinburgh in Scotland. Dr. Fink has published over 340 neuroendocrine papers and several authoritative books, and is past president of the European Neuroendocrine Association. Donald W. Pfaff heads the Laboratory of Neurobiology and Behavior at The Rockefeller University. He received his scientific training at Harvard College and MIT. He is a Member of the U.S. National Academy of Sciences and a Fellow of the American Academy of Arts and Sciences. Pfaff's laboratory focuses on steroid hormones and brain function, genes influencing neuronal functions, and generalized CNS arousal. He is the author or coauthor of over 10 books and more than 900 research publications.