The only advanced book for researchers and graduate students in neuroscience and neurobiology to offer comprehensive coverage of the neurobiology of brain disorders
1. An Introduction: A Clinical Neuroscientist and Disorders of the Brain Section I: Developmental Disorders2. Introduction3. Developmental Disabilities and Metabolic Disorders4. Attention-Deficit/Hyperactivity Disorder5. Down Syndrome: A Model for Chromosome Abnormalities6. Autism Spectrum Disorder7. Rett Syndrome: From the Involved Genes to Treatment8. Fragile X-associated DisordersSection II: Diseases of the Peripheral Nervous System9. Introduction10. Myasthenia Gravis 11. Muscular Dystrophy12. Peripheral Neuropathies and Guillain-Barré Syndrome13. Diabetes and Its ConsequencesSection III: Diseases of the Central Nervous System and Neurodegeneration14. Introduction15. Spinal Cord Injury16. Traumatic Brain Injury17. Epilepsy18. ALS and Related Motor Neuron Disorders (Including Spastic Paraplegia)19. Parkinsonian Syndromes20. Huntington Disease21. Alzheimer Disease and Other Dementias22. Cerebrovascular Disease23. Prion DiseaseSection IV: Infectious and Immune–mediated Diseases Affecting the Nervous System24. Introduction25. Inflammation in Neurological Disease 26. Inflammation in Psychiatric Disease27. Infectious Diseases of the Nervous System28. AIDS29. Autoimmune Neurological Disorders: Idiopathic and Paraneoplastic30. Multiple SclerosisSection V: Diseases of Higher Function31. Introduction32. Disorders of Higher Cortical Function 33. Disorders of Frontal Lobe Function 34. Stress35. Addictions 36. Sleep Disorders, Narcolepsy, and Restless Leg Syndrome37. Anxiety Disorders and Post-traumatic Stress Disorder38. Obsessive Compulsive Disorder39. The Neurobiology of Schizophrenia 40. Bipolar Disorders41. Pain42. Headache and Migraine43. Depression and SuicideSection VI: Diseases of the Nervous System and Society44. Introduction45. Ethical Issues that Emerge from Research (Basic)46. Burden of Neurological Disease47. Stress, Race, and Health Disparities
Affiliation: Professor of Neurology, Department of Neurology,
University of Pittsburgh, Pennsylvania, U.S.A
Over the past year, Dr. Zigmond and his research team have
continued their studies of cellular and animal models to examine
Parkinson's disease (PD), which they believe is a multi-factorial
disorder. A major focus of the lab is the role of intracellular
signaling cascades in determining the viability of dopamine (DA)
neurons. They hypothesize, for example, that trophic factors such
as GDNF and oxidative stress can both stimulate intracellular
survival cascades, including those involving MAP kinases. They
further believe that endogenous trophic factor expression can be
enhanced by exercise which in turn can be neuroprotective. And they
have evidence that protection also can derive from acute exposure
to low levels of a neurotoxin, a form of preconditioning. Last year
their work included studies of the impact of oxidative stress
induced by 6-hydroxydopamine (6-OHDA), a DA analogue that is
concentrated in DA cells and rapidly breaks down to form reactive
oxygen species. Results from these and other studies suggest that
DA neurons react to stress by initiating a set of protective
responses. Learning more about these responses may provide insights
into new treatment modalities for PD.
In the coming year, Dr. Zigmond will continue to focus on
understanding the strategies DA neurons use to reduce their
vulnerability to intracellular stress. For example, studies are
underway to determine if inhibition of trophic actor action or of
kinase activation will block neuroprotection seen with exercise or
GDNF or increase 6-OHDA toxicity. Some of these studies involve the
preparation of molecular biological tools that maintain kinases in
a constitutively or dominant negative state and/or localize a
kinase to the cytoplasm or the nucleus. In addition, histochemical
methods are being developed to quantify kinase levels in different
cellular compartments of identified cells.
Joseph T. Coyle, McLean Hospital, Harvard Medical School, Belmont,
Massachusetts, USA
"This terrific book provides very broad coverage of the neurobiological basis of common neurological and psychiatric disorders...highly recommended to anyone who wants to keep up to date with the basic sciences involved in neuropsychiatric disorders. Score: 88 - 3 Stars" --Doody's
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