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A comprehensive resource of DNA mixture interpretation and statistical analysis of DNA evidence, by the foremost expert in the field

Table of Contents

Section 1: DATA INTERPRETATION Chapter 1: Data Interpretation Overview Chapter 2: Data, Models & Thresholds Chapter 3: STR Alleles & Artifacts Chapter 4: STR Genotypes Chapter 5: STR Profiles Chapter 6: DNA Mixtures Chapter 7: Low-Level DNA & Complex Mixtures Chapter 8: Troubleshooting Data Collection

Section 2: STATISTICAL INTERPRETATION Chapter 9: Statistical Interpretation Overview Chapter 10: STR Population Data Analysis Chapter 11: DNA Profile Frequency Estimates Chapter 12: DNA Mixture Statistics Chapter 13: Coping with Missing Alleles Chapter 14: Relationship Testing Chapter 15: Lineage Marker Statistics Chapter 16: Laboratory Reports: Communicating Results and Conclusions

APPENDICES Appendix 1: STR Allele Frequencies from U.S. Population Data Appendix 2: NRC I and NRC II Recommendations Appendix 3: DAB Recommendations on Statistics Appendix 4: Worked mixture example (by Dr. Michael D. Coble)

About the Author

John M. Butler is a NIST Fellow and Special Assistant to the Director for Forensic Science, Office of Special Programs, at the U.S. National Institute of Standards and Technology, in Gaithersburg, Maryland. Dr. Butler earned his PhD from the University of Virginia while doing DNA research in the FBI Laboratory's Forensic Science Research Unit. He has won numerous scientific awards, including being named Science Watch’s #1 world-wide high-impact author in legal medicine and forensic science over the last decade (July 2011). He has over 150 publications in this field and is a frequent presenter on the topic of DNA typing, and has authored four other DNA Typing books including Advanced Topics in Forensic DNA Typing: Methodology. For a detailed CV, visit http://www.cstl.nist.gov/strbase/butler.htm.

Reviews

"As a communicator and researcher engaged forensic DNA analyses, John Butler is at the pinnacle of his profession. As with the previous two volumes in this series, Butler leaves no stone unturned in the clarity of his A to Y coverage of forensic DNA interpretation. This book is bound to find its way onto the fingertips of practitioners, attorneys, and students." --Richard Saferstein, Ph.D., Chief Forensic Scientist (Retired)

"…It is an excellent companion to his prior book on methodology, providing important information on interpretation of results… The book should prove valuable to all people involved in processing and interpreting results used in forensic genetics and criminal investigation." -- Bruce McCord, Ph.D., Professor, Florida International University

"Advanced Topics in DNA Typing/Interpretation is Dr. John Butler’s best book yet in his critically acclaimed series of DNA text books..." --Stephen Patrick Hogan Adjunct Associate Professor of Biological Science and Criminal Justice, State University of New York at Albany