This book is a comprehensive overview of current insights into the function of large conductance voltage- and ca2+- activated k+ channels at the molecular, cellular and systemic levels
1. Biophysics of BK channel gating
Riccardo Olcese
2. Modulation of BK channel function by auxiliary beta and gamma
subunits
Jiusheng Yan
3. Posttranscriptional and posttranslational regulation of BK
channels
Mike Shipston
4. Protein network interacting with BK channels
Hongkyun Kim
5. Functional role of mitochondrial and nuclear BK channels
Tian-Ming Gao
6. Modulation of BK channels by small endogenous molecules and
pharmaceutical channel openers
Toshinori Hoshi
7. Modulation of BK channels by ethanol
Alex Dopico
8. BK channels in neurons
Alison Barth
9. BK channels in the pituitary and hypothalamus
Peter Duncan
10. BK channels in the inner ear
Sonja Pyott
11. BK channels in the vascular system
Gayathri Krishnamoorthy-Natarajan
12. Developing the molecular pharmacology of BK channels for
therapeutic benefit
Gregory John Kaczorowski
Candice Contet, Ph.D., is Assistant Professor at The Scripps Research Institute (TSRI), La Jolla, CA. She is an NIH-funded investigator with 15 years of experience in the study of drug addiction. She is a member of the Integrative Neuroscience Initiative on Alcoholism (INIA-WEST) consortium funded by NIAAA, and directs the Viral Vector Core of TSRI Alcohol Research Center. She has a documented track record of investigating the molecular changes elicited by drugs of abuse and their relevance to behavioral adaptations. She has authored more than 20 peer-reviewed publications. She is on the editorial board of the journal Frontiers in Molecular Neuroscience. She attended the Ecole Normale Superieure (Paris, France) and obtained her PhD from the University of Strasbourg (France). She completed her research training under the mentoring of Drs. Nick Rawlins, Brigitte Kieffer, Athina Markou and George Koob.
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