Table of Contents

1. Historical perspectives on psychosis risk CRISTINA MEI AND PATRICK D. MCGORRY 2. Principles of risk, screening, and prevention in psychiatry EMMA SONESON, JESUS PEREZ, AND PETER B. JONES I - Risk paradigms 3. At-risk mental states ALISON R. YUNG 4. Subjective disturbances in emerging psychosis: basic symptoms and self-disturbances FRAUKE SCHULTZE-LUTTER, CHANTAL MICHEL, RAHEL FL €UCKIGER, AND ANASTASIA THEODORIDOU 5. Schizotypy, schizotypal personality, and psychosis risk NEUS BARRANTES-VIDAL, ANNA RACIOPPI, AND THOMAS R. KWAPIL 6. Familial high risk and high-risk studies LIANA ROMANIUK, STELLA W.Y. CHAN, ALIX MACDONALD, JESSIKA E. SUSSMANN, ANDREW M. MCINTOSH, HEATHER C. WHALLEY, AND STEPHEN M. LAWRIE 7. Psychotic-like experiences in the general population COLM HEALY AND MARY CANNON 8. 22q11.2 deletion syndrome: a neurodevelopmental model of psychosis CORRADO SANDINI, STEPHAN ELIEZ, MAUDE SCHNEIDER, AND MARCO ARMANDO II - Specific areas and risk 9. Neuroimaging studies in people at clinical high risk for psychosis GEORGE GIFFORD, ROB MCCUTCHEON, AND PHILIP MCGUIRE 10. Genetic studies of psychosis HANNAH J. JONES, STANLEY ZAMMIT, AND JAMES T.R. WALTERS 11. Immune processes and risk of psychosis ADAM AL-DIWANI AND THOMAS ARTHUR NICHOLLS POLLAK 12. Neurochemical models of psychosis risk and onset DOMINIC OLIVER, GEMMA MODINOS, AND PHILIP MCGUIRE 13. Clinical risk factors for psychosis ASWIN RATHEESH, JESSICA A. HARTMANN, AND BARNABY NELSON 14. Cognitive risk factors for psychosis KELLY ALLOTT AND ASHLEIGH LIN 15. Society and risk of psychosis CRAIG MORGAN, TESSA ROBERTS, BRIAN O. DONOGHUE, AND ANDREW THOMPSON 16. Is there sufficient evidence that cannabis use is a risk factor for psychosis? MARCO COLIZZI AND SAGNIK BHATTACHARYYA III - Interventions 17. The ethics of identifying and treating psychosis risk PAOLO CORSICO AND ILINA SINGH JEAN ADDINGTON, DANIJELA PISKULIC, DANIEL J. DEVOE, OLGA SANTESTEBAN-ECHARRI, AND JACQUELINE STOWKOWY 19. Pharmacological intervention for people at risk of psychotic disorder E. BURKHARDT, K. LEOPOLD AND A. BECHDOLF 20. International services for assessing and treating psychosis risk CHRISTY L.M. HUI, W.C. CHANG, SHERRY K.W. CHAN, EDWIN H.M. LEE, Y.N. SUEN, AND ERIC Y.H. CHEN 21. New paradigms to study psychosis risk: clinical staging, pluripotency, and dynamic prediction RACHAEL SPOONER, JESSICA A. HARTMANN, PATRICK D. MCGORRY, AND BARNABY NELSON 22. Future directions in risk research NIKOLAI ALBERT, LOUISE BIRKEDAL GLENTHØJ, AND MERETE NORDENTOFT

About the Author

Dr Andrew Thompson is a Principal Research Fellow and Associate Professor at Orygen, the Centre for Youth Mental Health at the University of Melbourne, Australia. He is the lead psychiatrist for the EPPIC early psychosis service and the National headspace Early Psychosis program in Australia and is currently head of clinical psychosis research at Orygen. He also retains a position as Associate Professor at the University of Warwick in the UK.

Andrew trained in medicine at the University of Oxford and London and in psychiatry in Nottingham and Bristol. He has an MD in clinical psychiatry from the University of London. He has worked in early psychosis practice and research for over 15 years in both the UK and Australia. He was previously clinical lead for the PACE at risk for psychosis clinic in Melbourne and has been involved in a number of research projects through this clinic and through his work at the University of Bristol and the University of Warwick.

Andrew’s research interests include clinical risk factors for the development of psychosis and psychotic symptoms, novel treatments (including technology) in emerging or early psychosis, predictors of outcome in early psychosis and systems of care and prevention approaches in youth mental health. Dr Matthew Broome is a Senior Clinical Research Fellow at the Department of Psychiatry, University of Oxford, and a Consultant Psychiatrist at the Early Intervention in Psychosis Service, Oxford. He trained in medicine at the University of Birmingham and in Psychiatry at the Maudsley hospital (where he worked at the at risk for psychosis clinic (OASIS). He has previously been a Lecturer at the Institute of Psychiatry and an Associate Clinical Professor at The University of Warwick. He has previously edited books on subjects such as phenomenology and the interface between psychiatry and philosophy and has published over 100 research papers mostly relating to at risk for psychosis groups.