Section 1 - concept of humane experimental technique, types of
toxicity and key technologies.
Section 2 - 15 chapters on global contributions (scientific
societies; national validation centres, key laboratories and
regulatory bodies).
Section 3 - special areas of interest - chapters on cosmetics,
drugs, food safety, inhalation toxicity, carcinogenicity and
reproductive toxicology, biologicals, and clinical (human)
studies.
Data mining and sharing section - chapters on databases and
scientific journals.
Key technologies section: 5 chapters on microphysiology,
computational methods, integrated testing strategies, and
validation, and the book ends with chapters on lessons learned and
future prospects
Michael Balls graduated in Zoology at Oxford University in 1960, and after post-graduate studies in Geneva, Switzerland, and post-doctoral research in Berkeley, California, and Portland, Oregon, in the USA, returned to Britain in 1966, as a lecturer in the School of Biological Sciences at the University of East Anglia. In 1975, he moved to the University of Nottingham Medical School as a senior lecturer in the Department of Human Morphology, and subsequently became Professor of Medical Cell Biology. In 1995, he was made an Emeritus Professor of the University. Professor Balls became a Trustee of FRAME (Fund for the Replacement of Animals in Medical Experiments) in 1979, was Chairman of the Trustees from 1981 to 2013, and has been Editor-in-Chief of FRAME’s journal, ATLA (Alternatives to Laboratory Animals), since 1983. In 1993, Professor Balls became the first Head of the European Centre for the Validation of Alternative Methods (ECVAM), established as part of the European Commission's Joint Research Centre, located at Ispra, near Lake Maggiore, in Italy. He retired from the Commission in June 2002. After leaving the University of London (Queen Mary College; 1964-1970) with a PhD in Genetics, Robert Combes has held posts in academia, industry, and the charitable sector, including Reader in Toxicology at Portsmouth Polytechnic, Head of Mutagenicity and Cellular Toxicology at Inveresk Research International, Scotland, and Scientific Director, then Director, of FRAME (Fund for the Replacement of Animals in Medical Experiments), based in Nottingham (1994-2008). He has research interests in genetic toxicology, in vitro toxicology, xenobiotic biotransformation, in silico prediction systems and the Three Rs (Reduction, Refinement and Replacement) approach to animal experimentation. Dr Combes has published numerous papers, book chapters and conference proceedings, given presentations at many conferences and workshops, and served on many committees, including the ECVAM Scientific Advisory Committee (ESAC). He was elected a Fellow of the Institute of Biology (now the Royal Biological Society) in 1987, was Secretary of the United Kingdom Environmental Mutagen Society (UKEMS), and was Secretary, then President, of the European Society of Toxicology In Vitro (ESTIV), later to be elected an Honorary Member (2010), and has served on the editorial boards of several journals, including: ATLA Alternatives to Laboratory Animals, Toxicology in Vitro and Mutation Research. Dr Combes has acted as a co-editor for five scientific texts. Andrew Worth is a senior scientific officer at the European Commission’s Joint Research Centre (JRC), where he leads the Predictive Toxicology Group within the Chemical Safety and Alternative Methods Unit. The unit incorporates the EU Reference Laboratory for Alternative to Animal testing (EURL ECVAM), and is part of the JRC’s Directorate for Health, Consumers and Reference Materials. The JRC provides independent scientific and technical support to the European Commission and other policy makers in the EU. Dr Worth has degrees in Physiological Sciences and in Linguistics from Oxford University, and a PhD in Computational Toxicology from Liverpool John Moores University. He has over 180 publications in the area of predictive toxicology, and has a particular interest in the development and assessment of computational methods and their application in the regulatory assessment of chemical safety. During 2012, he held an ORISE fellowship while working at the US Food and Drug Administration's Center for Food Safety and Applied Nutrition (FDA CFSAN). Dr Worth is a member of the editorial boards of ATLA (Alternatives to Laboratory Animals) and Computational Toxicology.
"The aim of this book was to find more proper ways of searching for the scientific truth, to increase knowledge and thus to reduce incertitude to provide relevant and reliable valid and human basis for scientific policies and decisions which deeply affect the well-being of humans and the environment in which we live. The current book could be of interest to scientists as well as to students and teachers, but also for broader range of readers." --Veterinarska Stanica
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