Section I. Introduction to Mitochondrial Diseases 1. Mitochondrial
disease in neurology – Past, present, and future
Section II. Most Common Neurological Manifestations of
Mitochondrial Disease 2. Progressive external ophthalmoplegia 3.
Mitochondrial optic neuropathies 4. Leigh syndrome 5. Stroke-like
episodes in adult mitochondrial disease 6. Ataxia and spastic
paraplegia in mitochondrial disease 7. Peripheral neuropathy in
mitochondrial disease 8. Complex neurological and multisystem
presentations in mitochondrial disease
Section III. Diagnosing Mitochondrial Disease 9. Investigation of
oxidative phosphorylation activity and composition in mitochondrial
disease 10. Genetics of mitochondrial diseases: Current approaches
for the molecular diagnosis 11. Laboratory and metabolic
investigations 12. Neuroimaging in mitochondrial disease
Section IV. Therapy and Future Challenges 13. Currently available
therapies in mitochondrial disease 14. Reproductive options in
mitochondrial disease 15. Clinical trials in mitochondrial disease
16. Blood biomarkers of mitochondrial disease – One for all or all
for one? 17. Experimental therapy for mitochondrial diseases
Rita Horvath works in the Department of Clinical Neurosciences at the University of Cambridge, John van Geest Centre for Brain Repair, Cambridge, United Kingdom Michio Hirano is the Lucy G. Moses Professor, Director of the H. Houston Merritt Neuromuscular Research Center, and Chief of the Division of Neuromuscular Medicine in the Department of Neurology at the Columbia University Irving Medical Center, New York, NY, United States. Patrick Francis Chinnery works at the MRC Mitochondrial Biology Unit and Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom.
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