Part I: Transcriptional Regulation
1: Gene Expression and Transcriptional Regulation
2: CIS-acting Transcriptional Regulatory Elements
3: Trans-acting Factors
Part II: Transcriptional Pathophysiology
4: Mutations in Cis-acting Transcriptional Regulatory Elements
5: Mutations in Genes Encoding Transcription Factors:The Nuclear
Receptor Superfamily
6: Other Zinc-Finger Proteins: WT1 and GLI3
7: PAX Proteins
8: bHLH Proteins
9: Homeodomain Proteins
10: HMG Domain Proteins
11: POU Domain Proteins
12: Other Transcriptional Factor Families
13: Co-activators
14: General Transcription Factors
15: Somatic Cell Genetic Disease: Cancer
16: Epigenetic Disease: Teratogenesis
"This book has many strengths. It is very weel written in a clear,
persuasive style. The enthusiam and depth of knowledge that Gregg
Semenza has for his subject is evident in every chapter.... The
referencing is also very well judged, being both selective and
comprehensive." --Human Genetics
"...this book will be very useful to two diverse audiences.
Clinicians will be stimulated by the many examples and suggestions
provided, and hopefully will look at their patients who have
congenital and hereditary defects from a different perspctive.
Molecular biologists will be intrigued by the transcriptional
phenomena hidden behind a particular phenotype. This book
represents an important example of how medical sciences and
molecular biology may interact
profitably."--Nature Medicine
"The most useful chapters of the book are those...organized by
transcription factor family....Students of human biology will find
this material accessible, useful, and remarkably
thorough...."--CELL
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