Table of Contents

Part I: Introduction and Biographies
1: David H. Hubel
2: Torsten N. Wiesel
Part II: Background to Our Research
3: Cortical Neurophysiology in the 1950's
4: The Group at Johns Hopkins
5: The Move from Hopkins to Harvard
6: The New Department
Part III: Normal Physiology and Anatomy
7: Our First Paper, on Cat Cortex, 1959
8: Recordings from Fibers in the Monkey Optic Nerve
9: Recordings from Cells in the Cat Lateral Geniculate
10: Our Major Paper on Cat Striate Cortex, 1962
11: Recordings from the Cat Prestriate Areas, 18 and 19
12: Survey of the Monkey Lateral Geniculate Body--A Foray into Color
13: Recording Fibers in the Cat Corpus Collosum
14: Recordings in Monkey Striate Cortex, 1968
15: Another Visual Representation, the Cat Clare-Bishop Area
16 Encoding of Binocular Depth in a Cortical Area in the Monkey:
17: Anatomy of the Geniculo-cortical Pathway: The Nauta Method
18: Ocular Dominance Columns Revealed by Autoradiography
19: Regular Sequences of Orientation Shifts in Monkeys
20: Cortical Modules and Magnification in Monkeys
Part IV: Deprivation and Development
21: The First Three Kitten Deprivation Papers
22: The Second Group of Deprivation Papers
23: The Siamese Cat
24: Cells Grouped in Orientation Columns in Newborn Monkeys
25: Plasticity and Development of Monkeys Ocular Dominance Columns
Part V: Three Reviews
26: Ferrier Lecture, 1977
27: Nobel Lecture, David H. Hubel, 1981
Nobel Lecture, Torsten N. Wiesel, 1981
28: Epilogue: Summing Up
List of Papers Included
Glossary
Index
Today, Forty-six Years After Starting
Torsten Wiesel
David Hubel

About the Author

The authors were both awarded the 1981 Nobel Prize in Physiology or Medicine. David H. Hubel is John Franklin Enders University Professor of Neurobiology, Emeritus, at Harvard Medical School. Torsten N. Wiesel is Director of the Shelby White and Leon Levy Center for Mind, Brain and Behavior and President Emeritus of Rockefeller University. He is also Secretary General of the Human Frontier Science Program and President of the
International Brain Research Organization.

Reviews

...charming and interesting autobiographical essays. Alva Noe, TLS Extremely important Alva Noe, TLS All in all this is an excellent book and helps to set the work of Hubel and Wiesel in the context of real people doing real science. It also helps to connect the papers together in an appropriate set of sequences for those starting in the area - how it would have helped to have it around when I first started trying to teach visual physiology to medical students Physiology News, No 61 The entire book is an inspiration to read. The original papers and the additional chapters are beautifully written - which means that they are stylistically elegant, free from jargon and cliche and, above all, devoid of the current, vulgar, craze for acronyms and abbreviations and of other devices that serve to make science even more inaccessible ... Neuroscience should rejoice that, during a mere 25 years, its world was enriched not only by a wealth of knowledge but also by new standards of evidence and elegance of methodology which have left a permanent imprint. Brain, 128 The book's glory is that the commentaries sandwiching each paper illuminate the workings of one of the most productive collaborations in the history of biology. Hubel and Wiesel describe the joy of mom-and-pop science where the collaborators do the work and weigh what to do next ... the book brings their work all together - complete with the authors' retrospective evaluations of their work ... a gem in the history of the field and a core resource. Robert Wurtz in Science ... The entire book is an inspiration to read. The original papers and the additional chapters are beautifully written ... Read today, some 50 years after the initial work was published, the papers still retain their freshness and their capacity to arouse wonder, not only at the way in which nature has elaborated such an impressive organ, but also at the tenacity and the powerful conceptual thinking that was behind their collected work ... Neuroscience should rejoice that, during a mere 25 years, its world was enriched not only by a wealth of knowledge but also by new standards of evidence and elegance of methodology which have left a permanent imprint. Semir Zeki in Brain Advance praise for Brain and Visual Perception: For those who came of age admiring the scientific adventures of Hubel and Wiesel, this book is an opportunity to look back in wonder. For those who came after, it will be an inspiration. This is a marvel of a book, written in David Hubel's disarmingly engaging voice, a must have, a must read. Antonio Damasio, Neuroscientist and author of Descartes' Error and Looking for Spinoza David Hubel and Torsten Wiesel's book describes the wonderful period in neurophysiology when they worked on the early mammalian visual system. I found it fascinating reading. Francis Crick, Nobel Laureate and author of The Astonishing Hypothesis and What Mad Pursuit A rare opportunity to peek into the minds of two giants of twentieth century science. Each of their classic papers reads like a Sherlock Holmes novel, but the accompanying commentaries and autobiographies, packed with witty, whimsical asides and Hubelisms, bring out the human side of science - reminding us that great science is a judicious blend of intuition, imagination and sheer tenacity rather than a cold rational process of the kind one usually associates with Holmes. It's especially refreshing to see their low-tech approach in an era of high-tech 'big science' dominated by brain imaging and gee whiz neophrenology. V S Ramachandran, BBC Reith Lecturer for 2003 and author of A Brief Tour of Human Consciousness Hubel and Wiesel, as much as any other scientists, are responsible for our current view of the brain, its function, and how it is moulded by the environment. This book will provide students and established scientists alike insight into the roots of modern neuroscience, a view into one of the most productive collaborations in the field, and some of the best examples of scientific writing in the literature. David Ferster, Professor of Neurobiology and Physiology, Northwestern University, USA Beginning around 1960, David Hubel and Torsten Wiesel took the study of the brain and its development from the realm of philosophy to biology. These papers and the commentaries that accompany them put the reader inside the heads of the scientists who gave us our modern understanding of the cerebral cortex, often by asking the next logical question, but always with appreciation for the beauty of the system. Michael P. Stryker, W.F. Ganong Professor of Physiology, University of California, San Francisco, USA