SECTION I: Pathophysiology
1 Vascular Biology and Atherosclerosis of Cerebral Vessels
2 Mechanisms of Thrombosis and Thrombolysis
3 Cerebral Blood Flow and Metabolism: Regulation and
Pathophysiology in Cerebrovascular Disease
4 Histopathology of Brain Tissue Response to Stroke and Injury
5 Molecular and Cellular Mechanisms of Ischemia-Induced Neuronal
Death
6 Intracellular Signaling: Mediators and Protective Responses
7 The Neurovascular Unit and Responses to Ischemia
8 Mechanisms of Cerebral Hemorrhage
9 White Matter Pathophysiology
10 Inflammation and Immune Response
11 Mechanisms of Plasticity, Remodeling and Recovery
12 Genetics and Vascular Biology of Angiogenesis and Vascular
Malformations
SECTION II: Epidemiology and Risk Factors
13 Global Burden of Stroke
14 Stroke Disparities
15 Modifiable Risk Factors and Determinants of Stroke
16 Prognosis after Stroke
17 Vascular Dementia and Cognitive Impairment
18 Genetic Basis of Stroke Occurrence, Prevention and Outcome
19 Preventing a First Stroke
SECTION III: Clinical Manifestations 20 Classification of Ischemic
Stroke
21 Clinical Scales to Assess Patients with Stroke
22 Carotid Artery Disease
23 Anterior Cerebral Artery Disease
24 Middle Cerebral Artery Disease
25 Posterior Cerebral Artery Disease
26 Vertebrobasilar Disease
27 Lacunar Syndromes, Lacunar Infarcts, and Cerebral Small Vessel
Disease
28 Intracerebral Hemorrhage
29 Aneurysmal Subarachnoid Hemorrhage
30 Arteriovenous Malformations and Other Vascular Anomalies
31 Stroke and Other Vascular Syndromes of the spinal Cord
SECTION IV: Specific Conditions and Stroke
32 Cardiac Diseases
33 Atherosclerotic Disease of the Proximal Aorta
34 Stroke Related to Surgery and Other Procedures
35 Arterial Dissections and Fibromuscular Dysplasia
36 Collagen Vascular and Infectious Diseases
37 Reversible Cerebral Vasoconstriction Syndromes
38 Hypertensive Encephalopathy
39 Stroke and Substance Abuse
40 Moyamoya Disease
41 CADASIL: Cerebral Autosomal Dominant Arteriopathy with
Subcortical Infarcts and Leukoencephalopathy
42 Hematologic Disorders and Stroke
43 Migraine and Stroke
44 Cryptogenic Stroke
45 Cerebral Venous Thrombosis
SECTION V: Diagnostic Studies
46 Ultrasonography
47 Computed Tomography-based Evaluation of Cerebrovascular
Disease
48 Magnetic Resonance Imaging of Cerebrovascular Diseases
49 Cerebral Angiography
SECTION VI: Therapy
Part A: Medical Therapy
50 Prehospital and Emergency Department Care of the Patient with
Acute Stroke
51 Intravenous Thrombolysis
52 Antithrombotic Therapy for Treatment of Acute Ischemic
Stroke
53 General Stroke Management and Stroke Units
54 Critical Care of the Patient with Acute Stroke
55 Pharmacologic Modification of Acute Cerebral Ischemia
56 Treatment of "Other" Stroke Etiologies
57 Medical Therapy of Intracerebral and Intraventricular
Hemorrhage
58 Rehabilitation and Recovery of the Patient with Stroke
59 Interventions to Improve Recovery after Stroke
60 Enhancing Stroke Recovery with Cellular Therapies
61 Antiplatelet Therapy for Secondary Prevention of Stroke
62 Secondary Prevention of Cardioembolic Stroke
63 Conduct of Stroke-Related Clinical Trials
Part B: Interventional Therapy
64 Endovascular Therapy of Extracranial and Intracranial Occlusive
Disease
65 Endovascular Treatment of Acute Ischemic Stroke
66 Endovascular Treatment of Cerebral Aneurysms
67 Interventional Therapy of Brain and Spinal Arteriovenous
Malformations
68 Dural Arteriovenous Malformations
Part C: Surgical Therapy
69 Surgery of Anterior and Posterior Aneurysms
70 Surgery for Intracerebral Hemorrhage
71 Intraventricular Hemorrhage
72 Surgical Management of Cranial and Spinal Arteriovenous
Malformations
73 Surgical Cavernous Malformations and Venous Anomalies
74 Indications for Carotid Endarterectomy in Patients with
Asymptomatic and Symptomatic Carotid Stenosis
75 Extracranial to Intracranial Bypass for Cerebral Ischemia
76 Decompressive Craniectomy for Infarction and Hemorrhage
Professor of Neurology, Chairman, Department of Neurology, University of Texas Medical School at Houston; Director, Stroke Program, Memorial Hermann - Texas Medical Center, Houston, TX Eng H. Lo is a basic neurovascular scientist. He helped develop the neurovascular unit concept (Lo, Nat Rev Neurosci 2003; Tiedt et al, Nat Rev Neurol 2022).
"Authoritative, eminently readable, and current."-Journal of
Neurosurgery
"[F]or depth of coverage of individual subjects and as a reference
for cerebrovascular diseases, [Stroke] has become the
standard."-Annals of Internal Medicine
"Should be part of the libraries of all [those] who deal with
cerebrovascular disease." -JAMA
"Updating such a big reference work is a huge task, and by and
large the editors have succeeded in their task. They have assembled
many very distinguished authors and put together a pretty
comprehensive reference work." -Journal of Neurology Neurosurgery
and Psychiatry
Reviews of previous edition. "There are sections on
pathophysiology, epidemiology, clinical manifestation and
individual sections dealing with specific pathological conditions
explaining each in great depth. In addition, it has extensive
sections devoted to therapy including medical, interventional and
surgical. All this makes the book a one-stop-shop for stroke. As a
result, it is a work that will prove valuable to a wide range of
clinicians involved with providing stroke services, including
stroke physicians, acute care physicians, researchers, public
health physicians and those involved with rehabilitation
medicine...In comparison to the previous editions, the book has
definite a advantages in the form of picture quality and web
access. It is excellent value for the price as a reference book for
stroke, not radiology specific. The book would find its place in a
departmental radiology library. Overall, an excellent, up-to-date
reference volume." RAD, May 2012
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