Microbial Drug Resistance: A Historical Perspective. Ecology of Antibiotic Resistance Genes. Global Response Systems that Confer Resistance. Multidrug Efflux Pumps: Structure, Efflux, and Inhibition. Mechanisms of Aminoglycoside Antibiotic Resistance. Resistance to ß-Lactam Antibiotics Mediated by ß-Lactamases. Target Modification as a Mechanism of Antimicrobial Resistance. Antibiotic Permeability. Genetic Methods for Detecting Bacterial Resistance Genes. The Evolution and Epidemiology of Antibiotic Resistant Pneumococci. Antimicrobial Resistance in the Enterococcus. Methicillin Resistance in Staphylococcus aureus. Mechanism of Drug Resistance in Mycobacterium tuberculosis. Antibiotic Resistance in Enterobacteria. Resistance as a Worldwide Problem. Public Health Responses to Antimicrobial Resistance in Outpatient and Inpatient Settings. Antibacterial Drug Discovery in the 21st Century.

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Richard G. Wax, Kim Lewis, Abigail A. Salyers, Harry Taber

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