Part II. Neuropathology of the Human Hypothalamus and Adjacent
Brain Structures.
17. Vascular supply and vascular disorders. 17.1 Blood supply to
the hypothalamus and pituitary. 17.2 Vascular lesions of the
hypothalamus. 17.3. Choroid plexus of the third ventricle. 18.
Disorders of development and growth. 18.1 Anencephaly. 18.2
Transsphenoidal encephalocele and empty sella syndrome. 18.3
Congenital midline defects: optic nerve hypoplasia and septo-optic
dysplasia (De Morsier's syndrome). 18.4 Dystopia of the
neurohypophysis. 18.5 The optic chiasm. 18.6 The growth hormone
axis in development and aging. 18.7 Hydrocephalus. 18.8 Septum
pellucidum abnormalities. 19. Tumors. 19.1 Symptoms due to
hypothalamic tumors. 19.2 Germinoma and teratoma. 19.3 Hamartoma.
19.4 Glioma. 19.5 Craniopharyngioma, Rathke's cleft cysts and
xanthogranuloma. 19.6 Dermoid and epidermoid tumors. 19.7 Pineal
region tumors. 19.8 Tuberous sclerosis (Bourneville-Pringle
syndrome) and tumors of the hypothalamus. 19.9 Metastases. 19.10
Other tumors. 20. Hypothalamic infections. 20.1 Inflammatory
conditions affecting the hypothalamus. 20.2 Encephalitis lethargica
(Von Economo's encephalitis). 20.3 Acquired immunodeficiency
syndrome (AIDS). 21. Neuroimmunological disorders. 21.1
Neurosarcoidosis of the hypothalamus. 21.2 Multiple sclerosis (MS)
and the hypothalamus. 21.3 Langerhans' cell histiocytosis
(Hand-Schüller-Christian disease; histiocytosis-X).
21.4 Other neuroimmunological hypothalamic disorders and lesions.
22. Drinking disorders. 22.1 Pathology of the neurohypophysis. 22.2
Diabetes insipidus. 22.3 Primary polydipsia and adipsia. 22.4
Nocturnal diuresis. 22.5 Vasopressin hypersecretion in diabetes
mellitus. 22.6 Inappropriate secretion of vasopressin. 22.7
Wolfram's syndrome. 23. Eating disorders. 23.1 Prader-Willi
syndrome. 23.2 Anorexia nervosa and bulimia nervosa. 23.3 Other
eating disorders. 24. Reproduction, olfaction and sexual behavior.
24.1 Disorders of gonadotropic hormone regulation. 24.2 Olfaction,
anosmia, the vomeronasal organ (Jacobson's organ) and the
embryology of LHRH neurons. 24.3 Kallmann's syndrome. 24.4
Klinefelter's syndrome or testicular dysgenesis. 24.5 Sexual
differentiation of the brain and sexual behavior. 25. Hypothalamic
lesions following trauma and iatrogenic disorders. 25.1 Head/brain
injury. 25.2 Neuroleptic malignant syndrome. 25.3 Hypothalamic
injury by radiation. 25.4 Lesion of the pituitary stalk. 26.
Hypothalamic involvement in psychiatric disorders. 26.1 Psychiatric
symptoms due to tumors of the third ventricle. 26.2 Attacks of
laughter (gelastic epilepsy). 26.3 Ventromedial hypothalamus
syndrome and the effect of lesions on aggression. 26.4 Depression
and mania. 26.5 The hypothalamus in mental deficiency. 26.6
Obsessive-compulsive disorder. 26.7 Anxiety disorders. 26.8 Fatigue
syndromes. 26.9 Aggressive behavior. 27. Schizophrenia and autism.
27.1 Schizophrenia. 27.2 Autism. 28. Periodic disorders. 28.1
Kleine-Levin syndrome (periodic somnolence and morbid hunger). 28.2
Spontaneous periodic fever, hypothermia, Shapiro syndrome and
periodic Cushing's syndrome. 28.3 Acute intermittent porphyria.
28.4 Narcolepsy. 28.5 Epileptic seizures. 29. Neurodegenerative
disorders. 29.1 Alzheimer's disease and the hypothalamus. 29.2
Dementia with argyrophilic grains. 29.3 Parkinson's disease. 29.4
Huntington's disease. 29.5 Wernicke's encephalopathy, Korsakoff's
psychosis and Marchiafava-Bignami disease. 29.6
Adrenomyeloneuropathy, adrenoleukodystrophy and
hypothalamic-pituitary dysfunction. 29.7 Other neurodegenerative
disorders. 30. Autonomic disorders. 30.1 Temperature regulation.
30.2 Disturbed thermoregulation. 30.3 Cardiovascular regulation.
30.4 Cardiovascular disturbances. 30.5 Circumventricular organs:
lamina terminalis, subfornical organ and autonomic regulation. 30.6
Micturition. 30.7 Sleep. 31. Pain and addiction. 31.1 Opioid
peptides and other addictive compounds. 31.2 Pain and the
hypothalamus. 31.3 Headache. 32. Miscellaneous hypothalamic
syndromes. 32.1 Idiopathic hypothalamic syndrome of childhood, a
paraneoplastic syndrome. 32.2 Hypothalamic atrophy, Leigh's disease
and Cornelia de Lange's syndrome. 32.3 Diencephalic idiopathic
gliosis. 32.4 Mitochondrial encephalomyopathy, lactic acidosis and
stroke-like episodes (MELAS) syndrome. 32.5 Agenesis of the
diencephalon. 32.6 Tourette's syndrome. 33. Brain death and 'dead'
neurons. References. Subject Index for Part I and Part II.
This volume is part of the Handbook of Clinical Neurology series, the world's most comprehensive source of information in neurology. Now in its third generation, the series has an unparalleled reputation for providing the latest foundational research, diagnosis, and treatment protocols essential for both basic neuroscience research and clinical neurology.
Dick Swaab (1944) earned his medical and doctoral degrees at the
University of Amsterdam, where he became involved in brain research
during his third year of medical school. He was Director of the
Netherlands Institute for Brain Research from 1978 to 2005. Since
1979 he is Professor of Neurobiology at the Medical Faculty,
University of Amsterdam.
In 1985, Dr. Swaab founded the Netherlands Brain Bank (NBB) to
serve as a source of clinically and neuropathologically
well-documented research tissue. Since its founding, the Brain Bank
has provided samples from more than 4,000 autopsies to 500 research
groups in 25 countries. He was director of the NBB until 2005.
He is Leader Research team Neuropsychiatric Disorders, Neth. Inst
for Neuroscience, an institute of the Royal Netherlands Academy of
Arts and Sciences (KNAW). Swaab is also appointed for 2011-2017
Chao Kuang Piu Chair of Zhejiang University, Hangzhou, P.R.
China.
His major research interests focus on, sexual differentiation of
the human brain in relation to gender identity and sexual
orientation, aging of the brain, Alzheimer’s disease, the
neurobiological basis of depression, suicide and eating disorders.
He has published over 540 papers in SCI journals, authored more
than 200 chapters in books, and edited more than 60 books. Swaab
mentored 84 PhD students from which 16 are now full professor. He
is “Companion in the Order of the Dutch Lion, bestowed by her
Royal Majesty Queen Beatrix of the Netherlands. In 2008 Swaab
obtained the Academy medal for his role in national and
international neuroscience.
Dick Swaab is author of the 2 volume monograph The Human
Hypothalamus that appeared in the Handbook of Clinical Neurology
series, Elsevier, Amsterdam (1000 pp) and the Dutch best seller We
are our Brains (450.000 copies sold), that is translated in 14
languages. A children's version of the book (You are your brains)
has also appeared in Dutch in 2013 and Russian (2014). Swaab's
H-factor is 76.
In these "collected works" hypothalamic involvement is demonstrated
in lower, as well as many higher functions, and even in neurologic
and psychiatric disorders, such as memory and attention deficits,
mood and depression, narcolepsy, cluster headache, and
aggression-all conditions one would, intuitively, not associate
with the hypothalamus. If one book can change the traditional
clinical perception of the hypothalamus as an evoluntionary
ancient, endocrine structure of little importance, this monograph
will.
"Journal of Neuropathology and Experimental Neurology, March 2005"
Ask a Question About this Product More... |