Table of Contents

Contributing Authors Preface Acknowledgments VOLUME ONE PART 1: Molecular Biology of Cancer 1 Cancer: A Conceptual Framework 2 Genomics and Proteomics 3 Destabilization of the Cancer Genome 4 Telomeres, Telomerase, and Cell Immortalization 5 Cell Signaling 6 Cell Cycle 7 Programmed Cell Death Immortalization 8 Angiogenesis 9 Invasion and Metastasis 10 Cancer Stem Cells PART 2: Principles of Oncology 11 Etiology of Cancer: Tobacco 12 Etiology of Cancer: Cancer Susceptibility Syndromes 13 Etiology of Cancer: Viruses Section 1 RNA Viruses Section 2 DNA Viruses 14 Etiology of Cancer: Inflammation Tumor Immune Surveillance Inflammation and Tumorigenesis 15 Etiology of Cancer: Chemical Factors DNA Repair Protects the Host from Chemical Carcinogens Genetic Susceptibility to Chemical Carcinogenesis 16 Etiology of Cancer: Physical Factors Ultraviolet Light Asbestos 17 Etiology of Cancer: Dietary Factors Energy Alcohol 18 Etiology of Cancer: Obesity and Physical Activity 19 Epidemiology of Cancer 20 Principles of Surgical Oncology 21 Principles of Radiation Oncology Tumor Oxygenation 22 Principles of Medical Oncology 23 Principles of Immunotherapy 24 Principles of Health Services Research 25 Pharmacology of Cancer Chemotherapy 26 Pharmacology of Cancer Biotherapeutics 27 Pharmacology of Endocrine Manipulation 28 Design and Analysis of Clinical Trials PART 3: Practice of Oncology 29 Cancer Prevention: Tobacco Dependence and Its Treatment 30 Cancer Prevention: Chemoprevention 31 Cancer Prevention: Role of Surgery in Cancer Prevention 32 Genetic Counseling 33 Cancer Screening 34 Specialized Techniques in Cancer Management 35 Role of Endoscopy in Cancer Management 36 Cancer of the Head and Neck 37 Cancer of the Lung 38 Neoplasms of the Mediastinum 39 Cancers of the Gastrointestinal Tract 40 Cancers of the Genitourinary System 41 Cancer of the Testis VOLUME TWO 42 Gynecologic Cancers 43 Cancer of the Breast 44 Cancer of the Endocrine System 45 Sarcomas of the Soft Tissue and Bone 46 Benign and Malignant Mesothelioma 47 Cancer of the Skin 48 Melanoma 49 Neoplasms of the Central Nervous System 50 Cancers of Childhood 51 Lymphomas 52 Acute Leukemias 53 Chronic Leukemias 54 Plasma Cell Neoplasms 55 Paraneoplastic Syndromes 56 Cancer of Unknown Primary Site 57 Diagnosis and Treatment of Peritoneal Carcinomatosis 58 Immunosuppression-Related Malignancies 59 Oncologic Emergencies 60 Treatment of Metastatic Cancer 61 Stem Cell Transplantation 62 Infections in the Cancer Patient 63 Management of Adverse Effects of Treatment 64 Supportive Care and Quality of Life 65 Rehabilitation of the Cancer Patient 66 Societal Issues in Oncology 67 Information Systems in Oncology 68 Complementary, Alternative, and Integrative Therapies PART 4: Newer Approaches in Cancer Treatment 69 Gene Therapy 70 Cancer Immunotherapy 71 Focused Ultrasound 72 RNA Inhibition 73 Charged Particle Therapy 74 Robotic Surgery 75 Nanotechnology Appendix Index