Table of Contents

PART I INTRODUCTION

1 Life, Cell and Thermodynamics 1

2 Physical and Chemical Properties of Water 23

PART II BIOMOLECULES

3 Overview of DNA Structure, Function, and Engineering 42

4 Amino Acids 80

5 Polypeptide Analysis, Sequencing and Evolution 97

6 Proteins: Structure and Folding 131

7 Physiological Activities of Proteins 180

8 Saccharide Chemistry 221

9 Lipids, Bilayer and Membranes 245

10 Passive and Active Transport 293

PART III ENZYMES

11 Mechanisms of Enzyme Action 322

12 Properties of Enzymes 361

13 Hormones and Signal Transduction 402

PART IV METABOLISM

14 Bioenergetics 442

15 Glycolysis and the Pentose Phosphate Pathway 478

16 Additional Pathways in Carbohydrate Metabolism 523

17 The Citric Acid Cycle 558

18 Mitochondrial ATP Synthesis 588

19 Photosynthesis: Can be found at www.wiley.com/college/voet

20 Synthesis and Degradation of lipids 664

21 Synthesis and Degradation of Amino Acids 718

22 Regulation of Fuel Metabolism 773

PART V GENE EXPRESSION AND REPLICATION

23 Nucleotide Synthesis and Degradation 802

24 DNA structure and Interactions with Proteins 831

25 DNA Synthesis and Repair 879

26 RNA Metabolism 938

27 The Genetic Code and Translation 982

28 Gene Expression in Prokaryotes and Eukaryotes 1033

Solutions: Can be found at www.wiley.com/college/voet

Glossary G-1

Index I-1