Table of Contents

Preface.- Section I: Epigenetic Marks and Mechanisms.- DNA methyltransferases (DNMTs), DNA damage repair, and cancer.- DNA hypomethylation and hemimethylation in cancer.- Ten Eleven Translocation (TET) Enzymes and 5-hydroxymethylation in Mammalian Development and Cancer.- Altered histone modifications in cancer.- Nucleosome occupancy and gene regulation during tumorigenesis.- Section II: The Impact of Epigenetic Alterations on Cancer Biology.- Epigenetic regulation of miRNAs in cancer.- DNA hypomethylation and activation of germline-specific genes in cancer.- APC and DNA demethylation in cell fate specification and intestinal cancer.- Epigenetic changes during cell transformation.- Epigenetic reprogramming of mesenchymal stem cells.- Section III: Clinical Implications and Analysis Methods.- Environmental toxicants, epigenetics, and cancer.- Blood derived DNA methylation markers of cancer risk.- Epigenetic therapies in MDS and AML.- Epigenetic targeting therapies to overcome chemotherapy resistance.- Methods for cancer epigenome analysis.- Index

Reviews

From the reviews:“This well-illustrated book is an excellent source of cutting-edge scientific information on epigenetic marks such as cytosine methylation and cytosine hydroxymethylation, histone tail modifications, histone variants and nucleosome positional information, recognized to play a fundamental role in cancer development and progression. … There are very few books available on this subject. This one will be very useful for students and researchers interested in knowing more about epigenetic alterations in oncogenesis.” (Omer Iqbal, Doody’s Book Reviews, August, 2013)