Table of Contents

Basic Cardiac Electrophysiology- Promises Kept and Promises to Keep.- Basic Physiology of Ion Channel Function.- Developmental Aspects of the Electrophysiology of the Heart: Function Follows Form.- Anatomic and Histopathologic Characteristics of the Conductive Tissues of the Heart.- Neural Regulation of the Heart in Health and Disease.- Mechanisms of Cardiac Arrhythmia.- Mechanisms of Action of Antiarrhythmic Drugs in Ventricular Arrhythmias.- Mechanisms of Action of Antiarrhythmic Drugs in Atrial Fibrillation.- Mechano-Electrical Interactions and their Role in Electrical Function of the Heart.- Pathological Roles of the Cardiac Sodium Channel Late Current (late INa).- Sodium Ion Channelopathies.- L-Type Calcium Channel Disease.- Nerve Sprouting, Defibrillation and Calcium Waves.- K+ Channelopathies (IKs, IKr, and Ito).- Cardiac ATP-Sensitive Potassium Channels and Associated Channelopathies.- Cardiac KATP Channels in Health and Diseases.- Ca2+ Release Channels (Ryanodine Receptors) and Arrhythmogenesis.- Caveolae and Arrhythmogenesis.- Senescence and Arrhythmogenesis.- Comparisons of Substrates Responsible for Atrial versus Ventricular Fibrillation.- Single Nucleotide Polymorphisms in Health and Cardiac Disease.- Electrophysiological Remodeling in Heart Failure.- Ventricular Electrical Remodeling in Compensated Cardiac Hypertrophy.- Physiological and Other Biological Pacemakers.- Cardiac Memory: From Electrical Curiosity to Clinical Diagnostic and Research Tool.- Heritable Arrhythmogenic Channelopathies, Primary Electrical Diseases, and Sudden Cardiac Death.- Celebrating the Challenge of Cardiac Arrhythmias.- Congenital Long QT Syndrome.- Brugada Syndrome – Clinical and Genetic Aspects.- Brugada Syndrome: Cellular Mechanisms and Approaches to Therapy.- Early Repolarization Syndrome: Epidemiology, Genetics, and Risk Stratification.- Catecholaminergic Polymorphic Ventricular Tachycardia.- Andersen-Tawil and Timothy Syndromes.- Short QT Syndrome.- Progressive Cardiac Conduction Disease.- Genetics of Atrial Fibrillation.- Idiopathic Ventricular Fibrillation.

About the Author

Ihor Gussak, MD, PhD, Charles Antzelevitch, PhD, FACC, FAHA, FHRS, Arthur A.M. Wilde, MD, PhD, Brian D. Powell, MD, Michael J. Ackerman, MD, PhD and Win-Kuang Shen, MD