Promotional Information

Springer Book Archives

Table of Contents

1 Influence of Genes of the Major Histocompatibility Complex on theReactivity of Thymus-Derived Lymphocytes.- I. Introduction.- II. Constraints Imposed on T-Cell Activities by Genes of the Major Histocompatibility Complex.- III. Implications of MHC-Imposed Restrictions for Antigen Perception by T Lymphocytes.- IV.MHC-Linked Ir Gene Control of Immune Responsiveness.- V.Relationship between MHC-Imposed Constraints and MHC-Linked Ir Gene Control of Immune Responsiveness.- VI.Concluding Remarks.- VII.References.- 2 Characterization of Human T-Cell Subpopulations as Defined by Specific Receptors for Immunoglobulins.- I. Introduction.- II. Basic Features of Distinct T-Cell Subpopulations and Their Receptors for Immunoglobulins.- A. Preparation of Purified Human T Cells.- B. Rosette Techniques for Detection of Receptors for IgM and IgG.- C. Specificity of T-Cell Receptors for IgM and IgG.- D. Receptors for IgM and IgG Discriminate between Distinct Subpopulations of T Cells.- E. Turnover of Receptors for IgM and IgG on T Cells.- F. Tissue Distribution of T.M and T.G Cells.- G. Morphology of T.M and T.G Cells.- III. Functional Analysis of T.M and T.G Cells.- A. Response to Mitogens and Allogeneic Cells.- B. Response to Pokeweed Mitogen as an in Vitro Model for Human T- and B-Cell Interactions.- C. Identification of T.M Cells as “Helper” Cells.- D. Suppressor Capacity of T.G Cells.- E. Mode of Suppression by T.G Cells.- IV. T.M and T.G Cells in Immunodeficiency Diseases and Malignancies.- A. Immunodeficiencies.- B. Leukemias.- V. Concluding Remarks and Speculations.- VI. References.- 3 Metazoan and Protozoan Parasitic Infections in Nude Mice.- I. Introduction.- II. Nematodes.- A. Nippostrongylus brasiliensis.- B. Ascaris suum.- C. Other Nematodes.- III. Cestodes.- A. Hymenolepis Species.- B. Taenia taeniaeformis.- C. Mesocestoides corti.- IV. Trematodes.- A. Schistosoma mansoni and Fasciola hepatica.- V. Protozoa.- A. Giardia muris and Hexamita muris.- B. Plasmodium and Babesia Species.- C. Other Protozoa.- VI. Concluding Remarks.- VII. References.- 4 In Vitro Induction and Expression of T-Cell Immunity to Tumor-Associated Antigens.- I. Introduction.- II. Methodology.- A. In Vitro Induction of Tumor-Specific Immunity.- B. In Vitro Assay of Tumor-Specific Immunity: 51Cr Release.- C. Important Parameters of Induction and Assay.- D. Cellular Competitive Inhibition in Vitro Assay.- III. Induction of CL in “Unstimulated” Cultures.- IV. Role of theMHC at theInductive Phase of T-Cell Immunity in Vitro to TAA.- V. Role of theMHC at theEffector Phase of Tc Immunity in Vitro to TAA.- VI. Comments and Conclusions.- VII. References.- 5 Systemic and Local Immunity in Allograft and Cancer Rejection.- I. Introduction.- II. Histology of Allograft Rejection and Host Response against Solid Tumors.- A. Histology of Allograft Rejection.- B. Changes in theCentral Lymphatic System during Allograft Rejectionll.- C. Histology and Prognostic Significance of Host Response to Cancer.- D. Histological Studies of in Situ Mechanisms of Antitumor Defense.- E. Changes in the Central Lymphatic System during Tumor Growth.- III. Effector Mechanisms in the Central Lymphatic System.- A. Cytotoxic T Lymphocytes and Allograft Rejection.- B. Functions of theCytotoxic T Lymphocytes.- C. Central Effector Mechanisms in Antitumor Responses.- IV. Isolation of Infiltrating Cells and Antibodies from Allografts and Tumors.- V. Identification of Infiltrating Cells in Allografts and Tumors.- A. Composition of Cellular Infiltrates in Allografts.- B. Receptor Specificity of Allograft-Infiltrating Cells.- C. Immunological Analysis of Tumor-Infiltrating Cells from Histological Sections of Solid Tumors.- VI. Effector Mechanisms Inside Allografts and Tumors.- A. Functional Analysis of Allograft-Infiltrating Cells.- B. Role of Antibody in Allograft Destruction.- C. Functional Analysis of Effector Cell Populations in Tumor Infiltrates.- D. Role of Antibody in Solid Tumors.- VII. Correlations between Local and Systemic Immunity.- A. In Antiallograft Responses.- B. In Antitumor Responses.- VIII. Concluding Remarks.- IX. References.- 6 Natural Killer Cells in theMouse: An Alternative Immune Surveillance Mechanism?.- I. Introduction.- II. General Characteristics of theNK System.- III. Specificity of Mouse NK Cytolytic Activity.- IV. Effector Cell Analysis.- A. NK Cells Lack Characteristics of Mature T Cells.- B. NK Cells Lack Characteristics of B Cells and of Monocyte-Macrophages.- C. Relationship between NK Activity and ADCC.- D. NK Cells Possess HP Receptors.- E. Non-T-Cell Nature of Genetically Controlled Tumor Resistance.- VI. Influence of Genetic and Nongenetic Factors on NK Activity.- A. Age Influence on in Vitro NK Activity.- B. Age Influence on in Vivo Tumor Resistance.- C. Effect of Tumor Induction and of Immunization with Tumor Cells on NK Activity.- D. Induction of NK Cell Activity by Bacterial Adjuvants ..- E. Genetic Analysis of NK Activity.- F. Genetic Analysis of Resistance to YAC Cells in Semisyngeneic Mice.- VI. Relationship between NK Activity and Resistance to Hemopoietic Grafts.- VII. Generation of NK Cells in Vivo.- A. Dependence on Intact Bone Marrow Function.- B. NK Function Is Preprogrammed at thePrecursor Cell Level.- C. Role of theThymus.- D. Role of theSpleen.- VIII. Concluding Remarks.- IX. References.- 7 Allotypes of IgM and IgD Receptors in theMouse: A Probe for Lymphocyte Differentiation.- I. Lymphocyte Surface Immunoglobulin.- A. Use of Antiimmunoglobulin Sera to Study Lymphocyte Receptors.- B. What Classes of Immunoglobulin Are Present on the Surface of Lymphocytes?.- II. Preparation of Antisera to Murine IgD.- A. Antigen Purification by Affinity Chromatography.- B. Antibodies to IgD in Murine Alloantisera.- III. Allotypes of Murine IgM.- A. Antibodies to IgM in “Conventional” Antiallotype Sera.- B. Antibodies to IgM in Antilymphocyte Alloantisera.- C. Specificity Analysis by Radioimmunoassay.- IV. Immunofluorescence Studies of Surface IgM and IgD.- A. General Method for theStudy of Lymphocyte Surface Alloantigens by Indirect Immunofluorescence.- B. Organ Distribution of Surface IgM and IgD.- C. Ontogeny of IgM and IgD Receptors.- D. Surface Immunoglobulin on Antibody-Containing Cells.- E. Capping of Surface IgM and IgD.- F. Allelic Exclusion and Haplotype Exclusion.- V. Implications for Organization of Immunoglobulin Heavy-Chain Genes.- A. The Heavy-Chain Linkage Group.- B. Shared V Regions, Class Switches, Haplotype Exclusion, and Clonal Restriction.- VI. Functional Role of B-Cell Receptors.- A. Immature Cells.- B. Mature Cells.- VII. Summary.- VIII. References.- 8 Immunoglobulin Isotype Expression.- I. Introduction.- II. Ontogeny of Immunoglobulin Isotypes.- III. In Vitro Activation of Mouse B Cells.- IV. Conclusions.- V. References.