Table of Contents

1 Pathophysiology of Perinatal Hypoxic-Ischemic Brain Damage.- I. Introduction.- II. Human Perinatal Hypoxia-Ischemia.- III. Neuropathology of Perinatal Hypoxia-Ischemia.- IV. Perinatal Central Nervous System Development.- V. Experimental Approaches to Perinatal Hypoxia-Ischemia.- VI. Conclusions.- References.- 2 Pathogenesis of Brain Dysfunction in Inborn Errors of Amino Acid Metabolism.- I. Introduction.- II. Effects of Metabolic Sequelae on the Fluxes and Transport of Amino Acids.- III. Effects of Metabolic Sequelae on Synthesis of Protein in Brain.- IV. Effects of Metabolie Sequelae on Substances Affecting Neurotransmission in Brain.- V. Effects of Metabolie Sequelae on Carbohydrate Metabolism and Energy Utilization.- VI. Effects of Metabolie Sequelae on Synthesis of Lipids and Myelin.- VII. Comments and Conclusions.- References.- 3 Disorders of Organic Acid Metabolism.- I. Introduction.- II. Inborn Errors of Leucine Metabolism.- III. Inborn Errors of Isoleucine and Valine Metabolism.- IV. Inborn Errors of Metabolism of Other Organic Acids.- V. Inborn Errors of Pyruvate Metabolism.- VI. Disorders of Organic Acid Metabolism Induced by Natural Toxin.- References.- 4 Biological Aspects of Affective Psychoses.- I. Introduction.- II. Clinical Features.- III. The Biogenic Amine Hypothesis.- IV. Indoleamines in Affective Disorders.- V. Lithium and Affective Disorders.- VI. Catecholamines and Affective Disorders.- VII. Neuroendocrine Function in Affective Disorders.- VIII. Conclusions.- References.- 5 Wilson’s Disease.- I. Copper Metabolism.- II. Copper Toxicity.- III. An Inherited Abnormality of Copper Metabolism: Wilson’s Disease.- References.- 6 Pathogenesis of Slow Infections of the Central Nervous System.- I. Introduction.- II. Slow Virus Subacute SpongiformEncephalopathies.- III. Slow Viral Encephalomyelitides.- References.- 7 Pathogenesis of Intrauterine Infections of the Brain.- I. Introduction.- II. Factors Required for the Initiation of Intrauterine Brain Infection.- III. Infections Affecting the Fetal or Newborn Central Nervous System.- IV. Possible Effector Mechanisms of Virus-Mediated Damage to the Developing Brain.- V. Fetal Immunological Response.- VI. Interferons.- VII. Discussion.- References.- 8 Ionizing Radiations and the Nervous System.- I. Introduction.- II. Some Radiobiological Considerations.- III. Developing Organisms.- IV. The Adult.- References.- 9 Brain Dysfunction in Congenital Malformations of the Nervous System.- I. Introduction.- II. Dysraphic States.- III. Cerebral Ageneses and Hypoplasias.- IV. Dysgenesis of the Cerebral Structures.- V. Developmental Cyst Formation.- VI. Congenital Hydrocephalus and Hydranencephaly.- VII. Synopsis.- References.- 10 Pathogenesis of Brain Dysfunction in Deficiency of Thiamine, Riboflavin, Pantothenic Acid, or Vitamin B6.- I. Introduction.- II. Thiamine Deficiency.- III. Riboflavin Deficiency.- IV. Pantothenic Acid Deficiency.- V. Vitamin B6 Deficiency.- References.

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