Contributors v

Introduction vii

1 The Blood Donor: Demographics, Donor Selection and Tests on Donor Blood 1
Liz Caffrey, Patricia Hewitt and John Barbara

2 Supply and Demand for Blood and Blood Components and Stock Management 6
Judith Chapman, Peter Garwood and Sue Knowles

3 Compatibility Testing Before Transfusion; Blood Ordering and Administration 10
Marcela Contreras and Aleksandar Mijovic

4 Red Cell Transfusion 15
Mike Murphy and Jonathan Wallis

5 Platelet and Granulocyte Transfusions 22
Modupe Elebute, Simon Stanworth and Cristina Navarrete

6 Haemolytic Disease of the Newborn and its Prevention 27
Fiona Regan, Sailesh Kumar and Marcela Contreras

7 Fetal and Neonatal Transfusion 33
Helen V. New and Sailesh Kumar

8 Plasma Products and Indications for Their Use 40
Hannah Cohen and Trevor Baglin

9 Human Albumin Solutions and the Controversy of Crystalloids Versus Colloids 48
Neil Soni

10 Treatment of Massive Haemorrhage in Surgery and Trauma 54
Tim Walsh

11 Immunological Complications of Blood Transfusion 61
Marcela Contreras and Cristina Navarrete

12 Infectious Complications of Blood Transfusion: Bacteria and Parasites 69
John Barbara and Marcela Contreras

13 Infectious Complications of Blood Transfusion: Viruses 74
John Barbara and Marcela Contreras

14 Variant Creutzfeldt–Jakob Disease and its Impact on the UK Blood Supply 79
Patricia Hewitt, James Ironside and Marcela Contreras

15 Risks of Transfusion in the Context of Haemovigilance: SHOT – the UK Haemovigilance System 83
Dorothy Stainsby, Hannah Cohen and Brian McClelland

16 Alternatives to Allogeneic Blood Transfusion 89
Dafydd Thomas and Beverley Hunt

17 Blood Substitutes and Oxygen Therapeutics 95
Kenneth C. Lowe

18 Appropriate Use of Blood and Better Blood Transfusion 99
Mike Murphy

19 Stem Cell Transplantation and Cellular Therapies 104
Aleksandar Mijovic, Derwood Pamphilon and Suzanne Watt

20 Blood Transfusion in a Regulatory Environment and the EU Directives 110
Shubha Allard, Clare Taylor and Angela Robinson

Index 117

About the Author

About the ABC of Transfusion

Edited by Marcela Contreras, DBE, Royal Free & University College Hospitals Medical School, London, UK and Blood Transfusion International

Table of Contents

About the Author