Table of Contents

1: The complement system: an introduction
2: Haemolytic assays for whole complement activity and individual components
3: Immunochemical methods for the detection of complement components and complement activation
4: Identification, functional assessment, and quantitation of receptors and membrane regulatory proteins whose ligands are C3 and C4
5: C1 inhibitor and HANe
6: Formation and regulation of the membrane attack complex
7: Purification of complement components
8: The anaphylatoxins
9: Complement genetics
10: Biosynthesis of complement components
11: Complement and immune complexes
12: Non-human complement

About the Author

Dr Alastair Dodds MRC Immunochemistry Unit Dept of Biochemistry University of Oxford South Parks Road Oxford OX1 3QU Tel: 01865 275795 Fax: 01865 275729 Email: al@bioch.ox.ac.uk Dr Robert Sim MRC Immunochemistry Unit Dept of Biochemistry University of Oxford South Parks Road Oxford OX1 3QU Tel: 01865 275351 Fax: 01865 275729

Reviews

"To those who are not actively engaged in the study of its biology and function, the complement system has remained one of the most formidable and dreaded subjects to deal with. . . . This manual . . . is therefore a very timely compilation of all the important protocols of assays that deal with the complement system. The book's twelve chapters are written by the most respected authorities in the field, and each chapter will serve the interests of researchers and clinicians. In addition, the book contains a useful list of suppliers and their addresses. . . . This compendium of different protocols for the isolation, purification and the study of complement structure and function will be a much needed manual, and an easy-to-read companion for both beginners and seasoned veterans. With such a wealth of information, this book provides an easily accessible reference source for clinicians, immunologists and students."--The Quarterly Review of Biology