Table of Contents

Part I. MOLECULAR AND CELLULAR BASIS OF HEMATOLOGY Chapter 1 Anatomy and Physiology of the Gene Edward J. Benz, Jr., Andrew Wagner, Nancy Berliner Chapter 2 Genomic Approaches to the Study of Hematologic Science Todd Golub and Scott Armstrong Chapter 3 Protein Synthesis, Processing, and Degradation Garabet G. Toby and David L. Wiest Chapter 4 Protein Architecture: Relationship of Form and Function Alan C. Rigby and Barbara C. Furie Chapter 5 Regulation of Cellular Response Benjamin G. Neel and Christopher Carpenter Chapter 6 Cell Adhesion Rodger P. McEver Chapter 7 Control of Cell Division William M.F. Lee and Chi V. Dang Chapter 8 Cell Death David M. Hockenbery and Stanley J. Korsmeyer Chapter 9 Pharmacogenomics and Hematological Diseases Loe Kager and William E. Evans Part II. IMMUNOLOGIC BASIS OF HEMATOLOGY Chapter 10 Overview and Compartmentalization of the Immune System Leland D. Powell and Linda G. Baum Chapter 11 B-Cell Development Kenneth Dorshkind and David J. Rawlings Chapter 12 T-Cell and NK-Cell Immunity Carol Clayberger and Alan M. Krensky Chapter 13 Dendritic Cell Biology Zbigniew M. Szczepiorkowski and Nina Bhardwhaj Chapter 14 Regulation of Activation of B and I Lymphocytes John C. Monroe and Lawrence Turka Chapter 15 Leukocyte Trafficking James J. Campbell, Steven Sloan, and Leslie E. Silberstein Chapter 16 Tolerance and Autoimmunity Mark J. Shlomchik Part III. BIOLOGY OF STEM CELLS AND DISORDERS OF HEMATOPOIESIS Chapter 17 Stem Cell Model of Hematopoiesis Anskar YH Leung and Catherine M. Verafaillie Chapter 18 Bone Marrow Microenvironment Mo Dao and Catherine M. Verfaillie Chapter 19 The Humeral Regulation of Hematopoiesis Montaser Shaheen and Hal Broxmeyer Chapter 20 Biology of Erythropoiesis, Erythroid Differentiation, and Maturation Thalia Papayannopoulou, Alan D'Andrea, Janis Abkowitz, and Anna Rita Migliaccio Chapter 21 Granulopoiesis and Monocytopoiesis Arati Khanna-Gupta and Nancy Berliner Chapter 22 Thrombocytopoiesis Michael W. Long and Ronald Hoffman Chapter 23 Thrombocytopenia Due to Decreased Platelet Production J. B. Opalinska and Alan M. Gewirtz Chapter 24 Inherited Forms of Bone Marrow Failure Melvin H. Freedman Chapter 25 Aplastic Anemia Neal S. Young and Jaroslaw P. Maciejewski Chapter 26 Paroxysmal Nocturnal Hemoglobinuria Rob A. Brodsky Chapter 27 Pure Red Cell Aplasia Emmanuel N. Dessypris Part IV. RED BLOOD CELLS Chapter 28 Pathobiology of the Human Erythrocyte and Its Hemoglobins Martin H. Steinberg, Edward J. Benz, Jr., Henry Adewoye, and Ben Ebert Chapter 29 Approach to Anemia in the Adult and Child Peter Marks and Bertil Glader Chapter 30 Anemia of Chronic Diseases Lawrence B. Gardner and Edward J. Benz, Jr. Chapter 31 Pathology of Iron Metabolism Nancy C. Andrews Chapter 32 Disorders of Iron Metabolism : Iron Deficiency and Overload Gary M. Brittenham Chapter 33 Heme Biosynthesis and Its Disorders: Porphyrias and Sideroblastic Anemias James S. Wiley and Michael R. Moore Chapter 34 Megablastic Anemias Aook C. Anthony Chapter 35 Thalassemia Syndromes Bernard G. Forget and Alan R. Cohen Chapter 36 Pathology of Sickle Cell Disease Robert P. Hebbel Chapter 37 Sickle Cell Disease Stephen H. Embury, Elliot Vichinsky, and Yogen Saunthararajah Chapter 38 Hemoglobin Variants Associated with Hemolytic Anemia, Altered Oxygen Affinity, and Methemoglobinemias Edward J. Benz, Jr. Chapter 39 Red Cell Enzymopathies Xylina T. Gregg and Josef T. Prchal Chapter 40 Red Cell Membrane Disorders Patrick G. Gallagher and Petr Jarolim Chapter 41 Autoimmune Hemolytic Anemias Melody J. Cunningham and Leslie E. Silberstein Chapter 42 Extrinsic Nonimmune Hemolytic Anemias Stanley L. Schrier and Erin Gourley Reid Part V. HOST DEFENSE AND ITS DISORDERS Chapter 43 Complement Biology and Immunoglobulin Gregory Kline, Robert Barrington, and Michael C. Carroll Chapter 44 Normal Phagocyte Structure and Function Robert L. Baehner Chapter 45 Eosinophilia, Eosinophil-Associated Diseases, Chronic Eosinophil Leukemia, and the Hypereosinophilic Syndromes Steven J. Ackerman and Joseph H. Butterfield Chapter 46 Disorders of Phagocyte Function and Number Mary C. Dinauer and Thomas D. Coates Chapter 47 Disorders of Lymphocyte Function Aileen M. Cleary, Richard A. Insel, and David B. Lewis Chapter 48 Histiocytic Disorders Jeffrey M. Lipton and Robert J. Arceci Chapter 49 Lysosomal Storage Diseases: Perspective and Principles Gregory A. Grabowski and Nancy Leslie Chapter 50 Infectious Mononucleosis and Other Epstein-Barr Virus-Associated Diseases Stephen Gottschalk, Cliona M. Rooney, and Helen E. Heslop Chapter 51 The Spleen and Its Disorders Susan B. Shurin Chapter 52 Basophils, Mast Cells, and Systemic Mastocytosis Robert I. Parker and Dean D. Metcalfe Part VI. HEMATOLOGIC MALIGNANCIES Chapter 53 Conventional Cytogenetics and Molecular Cytogenetics in Hematological Malignancies Gordon Dewald and Rhett P. Ketterling Chapter 54 The Molecular Basis of Neoplasia Carol Westbrook Chapter 55 Pharmacology and Molecular Mechanisms of Antineoplastic Agents for Hematologic Malignancies Stanton Gerson, Kapil N. Bhalla, Steven Grant, Richard Creeger, Nizar Bahlis Chapter 56 Radiation Therapy in the Treatment of Hematologic Malignancies Andrea K. Ng and Peter M. Mauch Chapter 57 Clinical Use of Hematopoietic Growth Factors Jacob M. Rowe and Irit Avivi Chapter 58 Radioimmunotherapy for B-Cell and Non-Hodgkin Lymphoma Thomas E. Witzig Chapter 59 Pathobiology of Acute Myeloid Leukemia Brian Huntly and D. Gary Gilliland Chapter 60 Clinical Manifestations of Acute Myeloid Leukemia Kenneth B. Miller and Philip R. Daoust Chapter 61 Therapy for Acute Myeloid Leukemia Elihu H. Estey and Hagop Kantarijan Chapter 62 Acute Myeloid Leukemia in Children Gary V. Dahl and Howard J. Weinstein Chapter 63 Pathobiology of Acute Lymphoblastic Leukemia A. Thomas Look and Adolpho Ferrando Chapter 64 Clinical Manifestations of Acute Lymphoblastic Leukemia Stacey L. Berg, C. Philip Steuber, and David G. Poplack Chapter 65 Treatment of Childhood Acute Lymphoblastic Leukemia Lewis B. Silverman, Stephen E. Sallan, and Harvey J. Cohen Chapter 66 Acute Lymphoblastic Leukemia in Adults Dieter Hoelzer and Nicola Gokbudget Chapter 67 Myelodysplastic Syndrome: Biology and Treatment Richard Stone and Daniel DeAngelo Chapter 68 Polycythemia Vera Ronald Hoffman, Kelty R. Baker and Joe Prchal Chapter 69 Chronic Myeloid Leukemia Charles Sawyers and Neil P. Shah Chapter 70 Myelofibrosis with Myeloid Metaplasia Ronald Hoffman and Farhad Ravandi-Kashani Chapter 71 Essential Thrombocythemia Steven Fruchtman and Ronald Hoffman Chapter 72 Myelodysplastic Syndromes and Myeloproliferative Syndromes in Children David M. Loeb, Robert P. Castleberry, and Cindy L. Schwartz Chapter 73 Pathobiology of Non-Hodgkin Lymphomas Gianluca Gaidano and Riccardo Dalla-Favera Chapter 74 Patho-Biology of Hodgkin's Lymphoma Stefano A. Pileri, Brunangelo Falini and Harold Stein Chapter 75 Hodgkin's Disease: Clinical Manifestations, Staging, and Therapy Volker Diehl, Daniel Re, and Andreas Josting Chapter 76 The Pathologic Basis for the Classification of Non-Hodgkin Lymphomas Elaine Jaffe and Stefania Piltaluga Chapter 77 Clinical Manifestations, Staging, and Treatment of Non-Hodgkin Lymphoma John G. Gribben and Ann S. La Casce Chapter 78 Malignant Lymphomas in Childhood John T. Sandlund, Jr.Michael P. Link Chapter 79 Chronic Lymphocytic Leukemia Dilip V. Patel and Kanti R. Rai Chapter 80 Hairy Cell Leukemia Annaadriana Zakanja, LoAnne C. Petersen, and Martin S. Tallman Chapter 81 Cutaneous T-Cell Lymphomas Timothy M. Kuzel, Joan Guitart, and Steven T. Rosen Chapter 82 AIDS-Related Lymphomas David T. Scadden Chapter 83 Multiple Myeloma and Other Plasma Cell Disorders Guido Tricot Chapter 84 Immunoglobulin Light Chain Amyloidosis (Primary Amyloidosis, AL) Morrie A. Gertz, Martha Q. Lacy, Angela Dispenzien Chapter 85 Atypical Immune Lymphoproliferations Timothy C. Greiner and Thomas G. Gross Chapter 86 Clinical Approaches to Infections in the Compromised Host Jo-Anne H. van Burik Chapter 87 Nutritional Support of Patients with Hematologic Malignancies Polly Lenssen and Saundra N. Aker Chapter 88 Psychosocial Aspects of Hematologic Disorders Ruth McCorkle, Siew Tzuh Tang, Jeannie Pasacreta Chapter 89 Pain Management and Antiemetic Therapy in Hematologic Disorders Janet L. Abrahm, Lauren Dias, and Bridget Fowler Chapter 90 Palliative Care Janet L. Abrahm and Barbara Sourkes Chapter 91 Indwelling Access Devices Janet L. Abrahm and Linda M. Pellerin Chapter 92 Late Complications of Hematologic Diseases and Their Therapies Wendy Landier and Smita Bhatia Part VII. TRANSPLANTATION Chapter 93 Hematopoietic Stem Cell Transplantation for Acquired Nonmalignant Diseases and Myelodysplastic Syndrome William Tse and H. Joachim Deeg Chapter 94 Hematopoietic Cell Transplant for Immune Deficiences and Genetic Diseases Stella M. Davies Chapter 95 Results of Allogeneic Hematopoietic Cell Transplant for Hematologic Malignancies Andrea Bacigalupo Chapter 96 Autologous Transplant for Hematologic malignancies and Solio Tumors Stephen J. Forman and Jeffery R. Schriber Chapter 97 Unrelated Donor Stem Cell Transplantation Therapy Effie W. Petersdorf and Claudio Anasetti Chapter 98 Umbilical Cord Blood Transplantation Juliet N. Barker and John E. Wagner Chapter 99 Preparative Regimens for Hematopoietic Cell Transplantation Marcos de Lima and Sergio Giralt Chapter 100 Graft-versus-Host Disease and Graft-versus-Leukemia Pavan Reddy and James L.M. Ferrara Chapter 101 Graft Engineering to Enhance Engraftment, Reduce Graft-versus-Host Disease and Provide a Graft-versus-Tumor Effect Catherine M. Bollard and Adrian P. Gee Chapter 102 Gene Transfer for Hematologic Disorders Katherine A. High and Malcolm K. Brenner Chapter 103 Experimental Cell Therapy Robert S. Negrin Chapter 104 Complications After Hematopoietic Cell Transplantation Daniel J. Weisdorf Part VIII. HEMOSTASIS AND THROMBOSIS Chapter 105 Megakaryocyte and Platelet Structure Joseph E. Italiano and John Hartwig Chapter 106 The Molecular Basis for Platelet Function Edward F. Plow and Charles S. Abrams Chapter 107 The Molecular Basis for Platelet Activation Lawrence F. Brass Chapter 108 The Blood Vessel Wall Aly Karsan and John M. Harlan Chapter 109 Molecular Basis of Blood Coagulation Bruce Furie and Barbara C. Furie Chapter 110 Molecular and Cellular Basis of Fibrinolysis H. Roger Lijnen and Desire Collen Chapter 111 Regulatory Mechanisms in Hemostasis: Natural Anticoagulants Charles T. Esmon Chapter 112 Clinical Evaluation of Hemorrhagic Disorders: Bleeding History and Differential Diagnosis of Pupura Barry S. Coller and Paul I. Schniederman Chapter 113 Laboratory Evaluation of Hemostatic Disorders Jacob H. Rand and Lisa Senzel Chapter 114 Structure, Biology, and Genetics of Factor VIII Randal J. Kaufman and Stylianos E. Antonarakis Chapter 115 Biochemistry of Factor IX and Molecular Biology of Hemophilia B S. Jamie Freedman and Bruce Furie Chapter 116 Clinical Aspects and Therapy of Hemophilia Jay Nelson Lozier and Craig M. Kessler Chapter 117 Inhibitors in Hemophilia Donald I. Feinstein Chapter 118 Other Clotting Factor Deficiencies Harold R. Roberts and Miguel A. Escobar Chapter 119 Disorders of Fibrinogen Jose Martinez and Andres Ferber Chapter 120 Structure, Biology, and Genetics of von Willebrand Factor David Ginsburg and Denisa D. Wagner Chapter 121 von Willebrand Disease: Clinical Aspects and Therapy Gilbert C. White, II, and J. Evan Sadler Chapter 122 Vitamin K: Metabolism and Disorders Barbara C. Furie and Bruce Furie Chapter 123 Inhibitors of Blood Coagulation Donald I. Feinstein Chapter 124 Disseminated Intrvascular Coagulation Howard A. Liebman and Ilene C. Weitz Chapter 125 Hemostatic Defects Associated with Dysproteinemias Howard A. Liebman Chapter 126 Disorders of Coagulation in the Neonate Leonardo R. Brandao and Donna DiMichele Chapter 127 Hypercoagulable States Kenneth A. Bauer Chapter 128 Venous Thromboembolism Mark A. Crowther and Jeffrey S. Ginsberg Chapter 129 Arterial Thromboembolism Mark A. Crowther and Jeffrey S. Ginsberg Chapter 130 Anticoagulation and Thrombolytic Therapy Jeffrey I. Weitz Chapter 131 Immune Thrombocytopenic Purpura, Neonatal Alloimmune Thrombocytopenia, and Posttransfusion Purpura James Bussel and Douglas Cines Chapter 132 Thrombotic Thrombocytopenic Purpura and the Hemolytic Uremic Syndrome Keith R. McCrae, J Evan Sadler, and Douglas Cines Chapter 133 Thrombocytopenia Due to Platelet Destruction and Hypersplenism Theodore E. Warkentin and John G. Kelton Chapter 134 Hereditary Disorders of Platelet Function Joel S. Bennett Chapter 135 Acquired Disorders of Platelet Function Jose Lopez and Perumal Thiagarajan Part IX. TRANSFUSION MEDICINE Chapter 136 Human Blood Group Anitgens and Antibodies Part 1: Carbohydrate Determinants Part 2: Protein Determinants Marion E. Reid and Martin L. Olsson Chapter 137 Human Platelet Antigens Thomas J. Kunicki and Diane J. Nugent Chapter 138 Human Leukocyte Antigen (HLA) and Human Neutrophil Antigen (HNA) Systems Ena Wang, Francesco M. Marincola, and David Stroncek Chapter 139 Principles of Red Blood Cell Transfusion Paul M. Ness and Margot S. Kruskall Chapter 140 Principles of Platelet Transfusion Therapy Thomas S. Kickler Chapter 141 Principles of Neutrophil (Granulocyte) Transfusions Ronald G. Strauss Chapter 142 Transfusion of Plasma Derivatives: Fresh-Frozen Plasma, Cryoprecipitate, Albumin, and Immunoglobulins Cassandra D. Josephson and Christopher D. Hillyer Chapter 143 Preparation of Plasma-Derived and Recombinant Human Plasma Proteins William N. Drohan and David B. Clark Chapter 144 Transfusion Therapy for Coagulation factor Deficiencies Catherine S. Manno and Peter Larson Chapter 145 Hemapheresis and Cellular Therapy Ellen F. Lazarus and Harvey G. Klein Chapter 146 Practical Aspects of Stem Cell Collection Scott D. Rowley, Stuart L. Goldberg, and Jack Hsu Chapter 147 Transfusion Reactions Edward L. Snyder and YanYun Wu Chapter 148 Transfusion-Transmitted Diseases Eberhard W. Fiebig, Michael P. Busch and Jay E. Menitove Chapter 149 Transfusion Medicine in Hematopoietic Stem Cell and Solid Organ Transplantation Richard M. Kaufman, Jerome Ritz and Walter H. Dzik Chapter 150 Red Blood Cell Substitutes Robert M. Winslow Part X. CONSULTATIVE HEMATOLOGY Chapter 151 Hematologic Manifestations of Systemic Disease: Liver and Renal Disease Rachel Rosovsky and Peter W. Marks Chapter 152 Hematologic Manifestations of Systemic Disease: Infection, Chronic Inflammation, and Cancer Peter W. Marks and David S. Rosenthal Chapter 153 Hematologic Manifestations of AIDS David H. Henry and James A. Hoxie Chapter 154 Hematologic Problems in the Surgical Patient: Bleeding and Thrombosis Mark T. Reding and Nigel S. Key Chapter 155 Hematologic Aspects of Pregnancy Edward J. Benz, Jr. Chapter 156 Hematologic Manifestations of Childhood Illness A. Kim Ritchey and Frank G. Keller Part XI. SPECIAL TESTS AND PROCEDURES Chapter 157 Bone Marrow Examination Daniel H. Ryan and Harvey J. Cohen Chapter 158 Automated Analysis of Blood Cells Raymond E. Felgar and Daniel H. Ryan Chapter 159 Laboratory Detection of Hemoglobinopathies and Thalassemias Martin H. Steinberg and David Chui Chapter 160 Antenatal Diagnosis of Hematologic Disorders Kim Kramer and Harvey J. Cohen Chapter 161 Use of Molecular Techniques in the Analysis of Hematologic Diseases Michele Paessler and Adam Bagg Chapter 162 Molecular Imaging in Hematology Francis G. Blankenberg Appendix Normal Blood Values: Selected Reference Values for Neonatal, Pediatric, and Adult Populations Sharon M. Geaghan