Table of Contents

Frontispiece Foreword by Francis Crick Preface Note on References to Source Material List of Plates Introduction Note to the Introduction (1994) "Section I From Colloidal Particles to Long-Chain Molecules: Bergmann, Staudinger, Svedberg, Polanyi, Mark, Astbury" Chapter 1 The Macromolecule Chapter 2 The Ultracentrifuge Chapter 3 The Fibre Diagram and the Long-Chain Molecule Chapter 4 The Leeds School under Astbury Chapter 5 Astbury under Attack "Section II Nucleic Acids and the Nature of the Hereditary Material: Levene, Caspersson, Garrod, Muller, Darlington, Stanley" "Chapter 6 Kossel, Levene and the Tetranucleotide Hypothesis" Chapter 7 The Nucleoprotein Theory of the Gene Chapter 8 The Physiology of the Gene Chapter 9 The Enzyme Theory of Life Chapter 10 The Chemistry of Virus-Genes "Section III Bacterial Transformation, its Nature and Implications: Griffith, Avery, Boivin, Vendrely, Chargaff, Wyatt" Chapter 11 Bacterial Transformation Chapter 12 The Identity of the Transforming Substance Chapter 13 Support for Avery Chapter 14 Base Ratios "Section IV Intellectual Migrations: Delbruck, Schrodinger, Bernal, Perutz, Pauling, Watson and Crick" Chapter 15 Physicists in Biology: The Informational School Chapter 16 Physicists and Chemists in Biology: The Structural School "Chapter 17 Pauling, Caltech and the a-Helix" Chapter 18 Watson and Crick "Section V Hunting for the Helix: Wilkins, Gosling, Furberg, Franklin, Pauling, Watson and Crick" Chapter 19 DNA as a Single- or Multiple-Strand Helix Chapter 20 DNA as a Trip Helix Chapter 21 DNA as a Double Helix Chapter 22 Conclusion Postscript (1994) Bibliography Index

About the Author

Robert Olby is Research Professor in the Department of History and Philosophy of Science at the University of Pittsburgh. A historian of 19th- and 20th-century biology, he specializes in genetics and molecular biology. This book is considered a classic and was strongly endorsed by Francis Crick, co-discoverer of DNA and author of our Foreword.