Table of Contents

1. The "Brain of the Cell": Data Processing by Protein Networks
2. Supplying the Network with Energy: Basic Biochemistry of Signal Transduction
3. Evolution of Cellular Data Processing
4. Basic Equipment: G-Proteins, Second Messengers, and Protein Kinases
5. Signal Transduction by Receptors with Seven Transmembrane Domains
6. Signal Transduction by Serine/Threonine Kinase-Coupled Receptors
7. Signal Transduction by Tyrosine Kinase- and Protein Phosphatase-Coupled Receptors: A Late Invention of Evolution
8. Gene Transcription: The Ultimate Target of Signal Transduction
9. Signals Controlling mRNA Translation
10. Signal Transduction by Small G-proteins: The Art of Molecular Targeting
11. Mitogen-activated Protein Kinase and Nuclear Factor ĸß Modules
12. Cancer and Regulation of Cell Division
13. Signal Transduction by Proteolysis and Programmed Cell Death
14. Signal Transduction by Ions
15. Sensory Signal Processing
16. Signaling at Synapses: Neurotransmitters and Their Receptors
17. Putting Together the Pieces: The Approach of Systems Biology

About the Author

Friedrich Marks, PhD, is Professor of Biochemistry at the University of Heidelberg and Emeritus Department head, German Cancer Research Center. Dr. Marks has been teaching biochemistry, in particular signal transduction, for more than 30 years. His research has focused on the role of signaling reactions in tumor development. Ursula Klingmuller, PhD, is a lecturer at the University of Heidelberg and Head of the Systems Biology of Signal Transduction Division, German Cancer Research Center. Dr. KlingmulleraaC--(t)s research focuses on systems biology of signal transduction and dynamic pathway modeling. Karin Muller-Decker, PhD, is a lecturer at the University of Heidelberg and Head of the Tumor Models Units, German Cancer Research Center. Dr. Muller-Decker is conducting pioneering work on eicosanoid signaling in tumor development.

Reviews

"This book would be highly useful to undergraduate students in medical, bioinformatics or biological science that are studying or pursuing research into signal transduction, network or systems biology. This book would also appeal to graduate students or professionals moving into this field of research, without prior knowledge or experience...each chapter engages the reader and conveys the importance of biological systems and networks adequately, thus challenging the reader to continue viewing their specific focus or field of research in complete isolation." Immunology News, November 2010 "This book provides comprehensive coverage of signal transduction. Unlike other texts currently available, a common theme of data processing by cellular machinery runs through this book which makes it stand out favorably against the competition. Material is up-to-date and covers the areas that are at the forefront of cell signaling research today." Alexey Veraksa, University of Massachusetts, Boston "The diversity of appropriate cell cycle topics covered is impressive. Impressive amount of important information. Best summary of cell cycle biochemistry in a text." Bradley J Stith, University of Colorado "The organization of the proposed book is excellent. The fundamentals of data processing by protein networks and evolution of this data processing in the first two chapters is the unique feature of the book and sets up the framework of cell signal transduction. This should allow students to get a firm grip of the overall pictures of cell signalling networks before zooming into the specific topics. Such chapters are largely missing from other textbooks. Figures are well executed and informative." Wei-Jen Tang, Univesrity of Chicago