Table of Contents

Introduction
General Mechanistic Considerations
Nucleophilic Substitution at Aliphatic Carbon
Nucleophilic Addition to Electron-deficient C=C Double Bonds
Nucleophilic Addition to C=N Double Bonds
Nucleophilic Addition to C=O Double Bonds
Nucleophilic Addition to Unsaturated Nitrogen
Cycloaddition Reactions
Protonation of Enolates and Tautomerization of Enols
Oxidation
Reduction of Carbonyl Compounds
Kinetic Resolution of Racemic Alcohols and Amines
Desymmetrization and Kinetic Resolution of Anhydrides
Large-Scale Applications
Appendix: Tabular Survey of Organo-Catalysts, Synthesis and Application

About the Author

Albrecht Berkessel is full professor at the university of Cologne, Germany. His research interests are catalysis, combinatorial chemistry and solid phase chemistry.
Harald Groger is currently working at the Degussa AG. His research is focussed on enzymatic reactions and biocatalysis.

Reviews

"This fascinating monograph captures the diversity and power of an area of research whose roots extend deep within the organic chemistry literature, yet which has only recently achieved critical mass through the collective contributions of many present-day pioneers. ... is an essential addition to both academic and industrial research libraries, as well as to the personal collection of any scientist with an interest in catalysis or synthetic chemistry." Angewandte Chemie I.E.

"... well-written with clear, focused schemes... of great value to those involved in synthetic methodology, catalysis, and total synthesis." Journal of the American Chemical Society

"On the whole, the authors succeeded in covering a very broad range of reactions that are catalyzed by organic catalysts, and offer readers an excellent overview of the current situation in the field of asymmetric organocatalysis. This book can be recommended for all scientists working in the area of asymmetric catalysis, whether in industrial research and development or at the universities. Postgraduate students and postdoctoral researchers who have begun work on this rapidly growing field would derive considerable benefit from reading it."
Synthesis

"This monograph will be a valuable addition into personal collections of synthetic chemists and research libraries of academia and industry." E-STREAMS

"Bas Buch von Berkessel und Gröger ist eine umfangreiche Monographie über die asymmetrische Organokatalyse. Obwohl es schwierig ist, ein Buch über ein sich so rasch entwickelndes Gebiet zu schreiben, ist es den Autoren gelungen, dieses auf aktuellen Stand zu bringen. ... Die Lektüre dieses Buches sollte Pflicht sein für alle, die sich mit Organokatalyse befassen. Darüber hinaus ist es all denjenigen zu empfehlen, die sich für asymmetrische Katalyse oder organische Synthese interessieren. Das Buch gehört in jede chemische Bibliothek, und sollte in die Lehre der modernen Methoden der organischen Chemie Eingang finden."

Maria Hechavarria Fonseca, Mülheim/Ruhr, Nachrichten aus der Chemie, 05/2005


"...wird Generationen von Chemikern als Einführung in die moderne asymmetrische Organokatalyse dienen: Es ist das Buch schlechthin zum Thema."
Christian Burstein, Frank Glorius, Philipps-Universität Marburg
Angewandte Chemie + International Edition 2005 - 117/28