Table of Contents

1 Introduction1 A Brief History2 The Molecular Nature of Genes3 An Introduction to Gene Function2 Methods of Molecular Biology4 Molecular Cloning Methods5 Molecular Tools for Studying Genes and Gene Activity3 Transcription in Prokaryotes6 The Mechanism of Transcription in Prokaryotes7 Operons: Fine Control of Prokaryotic Transcription8 Major Shifts in Prokaryotic Transcription9 DNA-Protein Interactions in Prokaryotes4 Transcription in Eukaryotes10 Eukaryotic RNA Polymerases and Their Promoters11 General Transcription Factors in Eukaryotes12 Transcription Activators in Eukaryotes13 Chromatin Structure and Its Effects on Transcription5 Posttranscriptional Events14 Messenger RNA Processing I: Splicing15 Messenger RNA Processing II: Capping and Polyadenylation16 Other RNA Processing Events6 Translation 17 The Mechanism of Translation I: Initiation18 The Mechanism of Translation II: Elongation and Termination19 Ribosomes and Transfer RNA7 DNA Replication, Recombination, and Transposition20 DNA Replication I: Basic Mechanism and Enzymology21 DNA Replication II: Detailed Mechanism22 Homologous Recombination23 Transposition8 Genomes24 Genomics and Proteomics

About the Author

Received BS in Chemistry from The College of Wooster in 1964 Postdoctoral work at UC-San Francisco with William RutterAmerican Cancer Society Research Scholar for two years