Table of Contents

Contributors.
Foreword.
Preface.
Getting Started.
Assessing Available Information.
Organizing and Preliminary Planning for Surgical Research
Writing a Protocol: Animals, Humans, and Use of Biologic, Chemical, and Radiologic Agents.
Grantsmanship.
Informed Consent and the Protection of Human Research Subjects: Historical Perspectives and Guide to Current United States Regulations.
Animal Care and Maintenance.
Funding Strategies and Agencies: Academic-Industrial Relationships; Intellectual Property.
Statistical Considerations.
Use of Nonexperimental Studies to Evaluate Surgical Procedures and Other Interventions: The Challenge of Risk Adjustment.
Measuring Surgical Outcomes.
Design of Clinical Trials.
Using Administrative Data for Clinical Research.
Research in the Intensive Care Unit: Ethical and Methodological Issues.
Research in the Operating Room.
Effects of Age and Gender.
Strategies, Principles, and Techniques Using Transgenic and Knockout Mouse Models.
Tissue Culture, Cell Growth, and Analysis.
Hematopoietic Stem Cells: Basic Concepts and Applications to Surgical Research.
Base Molecular Biological Methods in Surgical Research: Genetic Library Construction, Screening, and DNA Sequencing.
Transcription.
Signal Transduction and Apoptosis.
Mechanisms and Regulation of Eukaryotic Protein Synthesis.
Organelle Studies: Mitochondria, Golgi, and Endoplasmic Reticulum.
Membrane Biology and Biophysics.
Molecular Epidemiology: Beyond Gene Discovery to Clinical Diagnostic Tools.
Shock Models: Hemorrhage.
Scoring Systems for Trauma Research.
Blunt Trauma Models: Fractures, Chest Trauma, Head Injury, Soft-Tissue Trauma, and Abdominal Trauma.
Trauma Models for Studying the Influence of Gender and Aging.
Animal Models of Burn Injury.
Wound Care Models.
Models of Adult Respiratory Distress Syndrome-Aspiration.
Tumor Angiogenesis.
Approaches to Adoptive Immunotherapy.
Metastasis: Biology and Experimental Models.
Cancer Genetics.
Cancer Gene Therapy.
Active Immunotherapy for Cancer.
Gastrointestinal Motility.
Models of Intestinal Secretion and Absorption.
Surgical Models of Inflammatory Bowel Disease.
Intestinal Regeneration and Adaptation Models.
Minimally Invasive Surgery.
Experimental Models and Endpoints for Studies of Intestinal Ischemia-Resperfusion Injury.
Gut Barrier Failure.
Developmental Studies in the Gastrointestinal Tract.
Animal Models of Liver Failure.
Portal Hypertension and Portacaval Shunt.
Animal Models of Liver Regeneration.
Animal Models for the Study of Hepatocyte Transplantation.
Biliary Stone Formation.
Models for the Study of Pancreatitis.
Models of Endocrine Insufficiency.
Animal Models in Transplantation.
Models to Study Surgical Nutrition and Metabolism.
Stable Isotopes.
Body Composition.
Energetics.
Models of Protein Metabolism.
Membrane Transport of Nutrients.
Models of Wound Healing in Growth Factor Studies.
Animal Models of Sepsis and the Multiple Organ Dysfunction Syndrome.
The Immuno-Inflammatory Response.
Antibiotic Trials.
Scoring Systems for Sepsis and the Multiple Organ Dysfunction Syndrome.
Cytokine Biology.
Biology of Nitric Oxide: Measurement, Modulation, and Models.
Endothelial Cell and Smooth Muscle Cell Biology in Vascular Disease.
Coagulation Biology.
Endovascular Research: Stents.
Noninvasive Vascular Measurements.
Techniques to Study Microcirculation.
Blood Substitutes in Surgery.
Research Models in Pediatric Surgery.
Research in Fetal Surgery.
Research in Plastic Surgery.
Research Methods in Neurosurgery.
Research in Urologic Surgery.
Research in Cardiac Surgery.
Research in Orthopedic Surgery.
Statistical Analysis-Specific Statistical Tests: Indications for Use.
Data Presentation: How to Write and Submit Abstracts and Papers.
Audiovisual Communications as a Research Skill.
Organizing and Managing Meetings and Conferences.
The Management and Organization of a Surgical Research Laboratory.
History and Philosophy of Surgical Research.
The Surgical Research Program as a Business Enterprise.
Nobel Laureates in Surgery.
Surgical Education Research.
Mathematical Modeling.
Information Resource Discovery for Surgeons: Databases and the Internet.
How to Review a Manuscript.
Academic Surgical Mentoring.
Ethics and Surgical Research.
The National Institutes of Health: Procedures and Performance.
Measuring the Performance of Surgical Research.
Virtual Reality and Surgery.
Surgeons and Health Services Research.
From Idea to Product: Financing and Regulatory Issues in Product Development.

Promotional Information

Key Features
* The first complete compendium detailing the process and procedures to perform surgical research
* Provides details on and compares various methodologies
* A must have resource for the surgical resident, fellow, or scientist
* Includes a listing of resources and web sites to help the researcher even further

Reviews

"The editors have brought together nearly 200 authors, whose bibliography represents a 'who's who' of North American academic surgery. With this large faculty the editors have crafted 100 chapters, yet they have brought a uniformity of style and presentation that makes for easy reading. ...This is an important text. It is simply a must for every academic surgical department and a useful aid for every surgical trainee embarking on a research project. The time taken to read it is well spent and will be rewarded with time saved exploring blind alleys." --P.R. O'Connell, Mater Private Hospital, in BRITISH JOURNAL OF SURGERY (February 2002)

"This book is a novel and important contribution. Its greatest value will certainly be to young surgical investigators. In this book, they will not only find encouragement and reinforcement for their own hard efforts but an extensive resource for technical starting points as well as advice regarding the research process. I know of no comparable book." --DOODY'S PUBLISHING REVIEWS (February 2002)

"...a truly incredible book. ...the most comprehensive manual on surgical research on the market. ...There is currently no other book like it. ...I cannot understate the importance of this impressive manual. In my opinion, Surgical Research is the most outstanding book to be published in a long time. Every academic surgeon should have a copy of this book on his or her shelf. ...this book should be required reading for all surgical residents." --Herbert Chen, U of Wisconsin, Dept of Surgery, in ANNALS OF SURGERY (July 2001)

"The book stands alone as a reference for those beginning in research, whether they are surgeons or not. A wide range of material is brought together in a single place for easy reference. ...Each chapter is written by a seasoned investigator and stands alone as a unique reference source for other investigators. The chapters are well written, thorough, and well referenced. As a whole, the book contains a wealth of information and gives important attention to topics rarely discussed, such as optimal use of audio-visual aids, the life cycle of a National Institutes of Health grant, meeting management, and running a research laboratory. ...Surgical Research is well constructed, with numerous well-designed and well-placed illustrations. It belongs in the library of anyone pursuing surgical research, as a unique reference source for what is going on in the field." --Alan T. Lefor, MD, Cedars-Sinai Medical Center, in JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (July 2001)