Table of Contents

Anatomy and Physiology of the Gene
Epigenetics and Epigenomics
Genomic Approaches to Hematology
Regulation of Gene Expression, Transcription, Splicing and RNA Metabolism
Protein Synthesis, Processing, and Trafficking
Protein Architecture: Relationship of Form and Function
Signaling Transduction and Metabolomics
Pharmacogenomics and Hematologic Diseases
Hematopoietic Stem Cell Biology
Stem Cell Model of Hematologic Malignancies
Hematopoietic Microenvironment
Cell Adhesion
Hematopoietic Cell Trafficking and Chemokines
Interactions between Hematopoietic Stem and Progenitor Cells and the Bone Marrow: Current Biology of Stem Cell Homing and Mobilization
Vascular Growth in Health and Disease
Cytokine/Receptor families and signal transduction
Control of Cell Division
Cell Death
Overview and Compartmentalization of the Immune System
B-Cell Development
T-Cell Immunity
Natural Killer Cell Immunity
Dendritic Cell Biology
Complement and Immunoglobulin biology leading to clinical translation
Tolerance and Autoimmunity
Biology of Erythropoiesis, Erythroid Differentiation, and Maturation
Granulocytopiesis and Monocytopoiesis
Thrombocytopoiesis
Inherited Forms of Bone Marrow Failure
Aplastic Anemia
Paroxysmal Nocturnal Hemoglobinuria
Acquired Disorders of Unilineage Blood Cell Production
Pathobiology of the Human Erythrocyte and Its Hemoglobins
Approach to Anemia in the Adult and Child
Pathophysiology of Iron Homeostasis
Disorders of Iron Metabolism: Iron Deficiency and Overload
Anemia of Chronic Diseases
Heme Biosynthesis and Its Disorders: Porphyrias and Sideroblastic Anemias
Megaloblastic Anemias
Thalassemia Syndromes
Pathobiology of Sickle Cell Disease
Sickle Cell Disease: Clinical Features and Management
Hemoglobin Variants Associated with Hemolytic Anemia, Altered Oxygen Affinity, and Methemoglobinemias
Red Blood Cell Enzymopathies
Red Blood Cell Membrane Disorders
Autoimmune Hemolytic Anemia
Extrinsic Nonimmune Hemolytic Anemias
Granulocytosis, Granulocytopenia, Monocytosis, and Monocytopenia
Lymphocytosis, Lymphocytopenia, Hypergammaglobulinemia, and Hypogammaglobulinemia
Disorders of Phagocyte Function
Congenital Disorders of Lymphocyte Function
Histiocytic Disorders
Lysosomal Storage Diseases: Perspectives and Principles
Infectious Mononucleosis and Other Epstein-Barr Virus-Associated Diseases
Progress in the Classification of Hematopoietic and Lymphoid Neoplasms: Clinical Implications
The CytoGenomic Basis of Hematological Malignancies
Pharmacology and Molecular Mechanisms of Antineoplastic Agents for Hematologic Malignancies
Pathobiology of Acute Myeloid Leukemia
Clinical Manifestations and Treatment of Acute Myeloid Leukemia
Myelodysplastic Syndromes: Biology and Treatment
Allogeneic Hematopoietic Stem Cell Transplantation for Acute Myeloid Leukemia and Myelodysplastic Syndrome in Adults
Acute Myeloid Leukemia in Children
Myelodysplastic Syndrome and Myeloproliferative Syndrome in Children
Pathobiology of Acute Lymphoblastic Leukemia
Clinical Manifestations and Treatment in Children of Acute Lymphoblastic Leukemia
Acute Lymphocytic Leukemia in Adults
Chronic Myeloid Leukemia
The Polycythemias
Essential Thrombocythemia
Primary Myelofibrosis
Eosinophilia, Eosinophil-Associated Diseases, Chronic Eosinophil Leukemia, and the Hypereosinophilic Syndromes
Mast Cells and Systemic Mastocytosis
The Pathologic Basis for the Classification of Non-Hodgkin and Hodgkin Lymphomas
Origins of Hodgkin Disease
Hodgkin Lymphoma: Clinical Manifestations, Staging, and Therapy
Origins of Non-Hodgkin Lymphomas
Chronic Lymphocytic Leukemia
Hairy Cell Leukemia
Clinical Manifestations and Treatment of Indolent Lymphomas: Marginal Zone Lymphomas (Extranodal/Malt, Splenic, and Nodal)
Clinical Manifestations, Staging, and Treatment of Follicular Lymphoma
Mantle Cell Lymphoma
Diagnosis and Treatment of Diffuse Large B-Cell Lymphoma (DLBCL) and Burkitt Lymphoma (BL)
Viral-Related Lymphomas
Malignant Lymphomas in Childhood
T-Cell Lymphomas
Multiple Myeloma
Waldenstrom Macroglobulinemia/Lymphoplasmacytic Lymphoma
Immunoglobuin Light-Chain Amyloidosis (Primary Amyloidosis)
Clinical Approach to Infections in the Compromised Host
Psychosocial Aspects of Hematologic Disorders
Pain Management and Antiemetic Therapy in Hematologic Disorders
Palliative Care
Late Complications of Hematologic Diseases and Their Therapies
Overview and Historical Perspective of Current Cell-Based Therapies
Practical Aspects of Hematologic Stem Cell Harvesting and Mobilization
IND Enabling Processes for Cell-Based Therapies
Graft Engineering and Cell Processing
Principles of Cell-Based Genetic Therapies
Mesenchymal Stromal Cells
T Cell Therapy of Hematological Diseases
NK Cell-Based Therapies
Immune Checkpoint Blockade in Hematologic Malignancies
Overview and Choice of Donor of Hematopoietic Stem Cell Transplantation
Indications and Outcomes of Allogeneic Hematopoietic Cell Transplantation for Hematologic Malignancies in Adults
Unrelated Donor Hematopoietic Cell Transplantation
Haploidentical Hematopoietic Cell Transplantation
Unrelated Donor Cord Blood Transplantation for Hematologic Malignancies
Graft-versus-Host Disease and Graft-versus-Leukemia Responses: Biology and Therapy
Complications after Hematopoietic Cell Transplantation
Human Blood Group Antigens and Antibodies
Principles of Red Blood Cell Transfusion
Clinical Considerations in Platelet Transfusion Therapy
Human Leukocyte Antigen and Human Neutrophil Antigen Systems
Principles of Neutrophil (Granulocyte) Transfusions
Transfusion of Plasma Derivatives: Plasma, Cryoprecipitate, Albumin, and Immunoglobulins
Preparation of Plasma-Derived and Recombinant Human Plasma Proteins
Transfusion Therapy for Coagulation Factor Deficiencies
Hemapheresis
Transfusion Reactions to Blood and Cell Therapy Products
Transfusion-Transmitted Diseases
Pediatric Transfusion Medicine
Overview of Hemostasis and Thrombosis
The Blood Vessel Wall
Megakaryocyte and Platelet Structure
Molecular Basis of Platelet Function
Molecular Basis of Blood Coagulation
Regulatory Mechanisms in Hemostasis
Clinical Approach to the Patient with Bleeding or Bruising
Laboratory Evaluation of Hemostatic and Thrombotic Disorders
Acquired Disorders of Platelet Function
Diseases of Platelet Number: Immune Thrombocytopenia, Neonatal Alloimmune Thrombocytopenia, and Posttransfusion Purpura
Thrombocytopenia Caused by Platelet Destruction, Hypersplenism, or Hemodilution
Heparin-Induced Thrombocytopenia
Thrombotic Thrombocytopenic Purpura and the Hemolytic Uremic Syndromes
Hemophilia A and B
Inhibitors in Hemophilia A and B
Rare Coagulation Factor Deficiencies
Structure, Biology, and Genetics of Von Willebrand Factor
Disseminated Intravascular Coagulation
Hypercoagulable States
The Antiphospholipid Syndrome
Venous Thromboembolism
Mechanical Interventions in Arterial and Venous Thrombosis
Atherothrombosis
Stroke
Acute Coronary Syndromes
Atrial Fibrillation
Peripheral Artery Disease
Antithrombotic Drugs
Disorders of Coagulation in the Neonate
Hematologic Changes of Pregnancy
Hematologic Manifestations of Childhood Illness
Hematologic Manifestations of Systemic Disease: Liver Disease
Hematologic Manifestations of Systemic Disease: Renal Disease
Hematologic Manifestations of Cancer
Integrated Therapies in Patients with Hematologic Diseases
Hematologic Manifestations of AIDS
Hematologic Manifestations of Parasitic Diseases
Hematologic Problems in the Surgical Patient: Bleeding and Thrombosis
The Spleen and Its Disorders
Hematology in Aging

APPENDIX:

Resources for the Hematologist: Interpretive Comments and Selected Reference Values for Neonatal, Pediatric, and Adult Populations

Reviews

"an excellent, detailed and modern textbook"

"The book covers all of hematology. It is truly comprehensive and awe inspiring. Pretty much everything you might want to know about anything hematological is in this book. The discussion of the pathophysiology of hematological disorders, spanning biochemistry to molecular to cellular to organ systems, is simply breathtaking in its enormity, accuracy, detail, and completeness.... Get this book. It is one of the best comprehensive references for clinical hematology." Reviewed by Valerie L. Ng, PhD, MD (Alameda County Medical Center/Highland Hospital) Doody's Score: 94, 4 Stars!