Table of Contents

Part I: An introduction to immunobiology and innate immunity Basic concepts in immunology. Innate immunity. Part II: The recognition of antigen Antigen recognition by B and T cell receptors. The generation of Lymphocyte antigen receptors. Antigen presentation to T lymphocytes. Part III: The development of mature lymphocyte receptor repertoires Signaling through immune system receptors. The development and survival of lymphocytes. Part IV: The adaptive immune response T-cell mediated immunity. The humoral immune response. Adaptive immunity to infection. Part V: The immune system in health and disease Failure of host defense mechanisms. Allergy and hypersensitivityAutoimmunity and transplantation. Manipulation of the immune response. Part VI: Where the immune system came from and where is immunology going Evolution Appendices The immunologists' toolbox. List of current CDs. Cytokines and their receptors. Chemokines and their receptors.