Table of Contents

Preface.

List of Contributors

1. The Insulin Receptor and Downstream Signalling (Ken Siddle).

2. Insulin-Mediated Regulation of Glucose Metabolism (Daniel Konrad, Assaf Rudich and Amira Klip).

3. Insulin Action on Lipid Metabolism (Keith N. Frayn and Fredrik Karpe).

4. The Effect of Insulin on Protein Metabolism (Laura J. S. Greenlund and K. Sreekumaran Nair).

5. Genetically Modified Mouse Models of Insulin Resistance (Gema Medina, Christopher Lelliott and Antonio J. Vidal-Puig).

6. Insulin Resistance in Glucose Disposal and Production in Man with Specific Reference to Metabolic Syndrome and Type 2 Diabetes (Henning Beck-Nielsen, Frank Alford and Ole Hother-Nielsen).

7. Central Regulation of Peripheral Glucose Metabolism (Stanley M. Hileman and Christian Bjørbæk).

8. Relationship Between Fat Distribution and Insulin Resistance (Philip G. McTernan, Aresh Anwar and Sudhesh Kumar).

9. PPARy and Glucose Homeostasis (Robert K. Semple and Stephen O’Rahilly).

10. Adipokines and Insulin Resistance (Daniel K. Clarke and Vidya Mohamed-Ali).

11. Dietary Factors and Insulin Resistance (Jeremy Krebs and Susan Jebb).

12. Physical Activity and Insulin Resistance (Nicholas J. Wareham, Søren Brage, Paul W. Franks and Rebecca Abbott).

13. Genetics of the Metabolic Syndrome (George Argyropoulos, Steven Smith and Claude Bouchard).

14. Insulin Resistance and Dyslipidaemia (Benoît Lamarche and Jean-François Mauger).

15. Insulin Resistance, Hypertension and Endothelial Dysfunction (Stephen J. Cleland and John M. C. Connell).

16. Insulin Resistance and Polycystic Ovary Syndrome (Neus Potau).

17. Syndromes of Severe Insulin Resistance (SSIRs) (David Savage and Stephen O’Rahilly).

18. Therapeutic Strategies for Insulin Resistance (Harpal S. Randeva, Margaret Clarke and Sudhesh Kumar).

19. Drug Therapy for Insulin Resistance – a Look at the Future (Bei B. Zhang and David E. Moller).

Index.

About the Author

Dr Sudhesh Kumar MD FRCP, Professor of Medicine (Diabetes &? Metabolism), Warwick Medical School, University of Warwick

Prof Steve O'Rahilly, Departments of Medicine and Clinical Biochemistry, Addenbrookes Hospital, Cambridge, UK

Reviews

"The book is intended for specialists…however with the current interest in obesity and the threats it poses to the general public health, others will also find it of interest." (E-STREAMS, September 2006) "...a major contribution to the increasing body of work...this book appears at an appropriate moment to educate and excite young investigators…" (New England Journal of Medicine, November 17, 2005)