Table of Contents

Preface.
Introduction: Drug Discovery in the 21st Century.


1. Natural Products (Charles B. Spainhour).


2. Cancer Cell Proteomics Using Molecular Aptamers (Weihong Tan,
Zehui Cao, Dihua Shangguan, Ying Li, Zhiwen Tang, Prabodhika
Mallikratchy, and Hui Chen).


3. Molecular Similarity Methods and QSAR Models as Tools for
Virtual Screening (Jürgen Bajorath).


4. Systems Biology: Applications in Drug Discovery (Sean Ekins,
Andrej Bugrim, Yuri Nikolsky, and Tatiana Nikolskaya).


5. High-Throughput Flow Cytometry (Larry A. Sklar, Peter C.
Simons, Anna Waller, Sean M. Biggs, Susan M. Young, Marius Olah,
Cristian Bologa, Tudor I. Oprea, Eric R. Prossnitz, and Bruce S.
Edwards).


6. Combining NMR Spectral Information with Associated Structural
Features to Form Computationally Nonintensive, Rugged, and
Objective Models of Biological Activity (Richard D. Beger, Dan A.
Buzatu, and Jon G.Wilkes).


7. Using Microsoft Excel® as a Laboratory Data Management
Tool (A. Erik Rubin, Mark F. Russo, and William Neil).


8. Age of Regulation (Sandy Weinberg and Gerald J.
Whartenby).


9. Simultaneous Screening of Multiple Cell Lines Using the
CellCard System (Oren E. Beske).


10. Protein X-ray Crystallography in Drug Discovery (Peter
Nollert, Michael D. Feese, Bart L. Staker, and Hidong Kim).


11. Biological and Chemistry Assays Available During Drug
Discovery and Developability Assessment (Duane B. Lakings).


12. Strategies and Methods in Monitoring and Targeting
Protein?Protein Interactions (Arianna Loregian and Giorgio
Palù)


13. High-Throughput Screening: Evolution of Technology and
Methods (Martyn N. Banks, Angela M. Cacace, Jonathan
O?Connell, and John G. Houston).


14. Metal-Enhanced Fluorescence: Application to High-Throughput
Screening and Drug Discovery (Kadir Aslan, Ignacy Gryczynski,
Joanna Malicka, Joseph R. Lakowicz, and Chris D. Geddes).


15. Methods for the Design and Analysis of Replicate-Experiment
Studies to Establish Assay Reproducibility and the Equivalence of
Two Potency Assays (Brian J. Eastwood, Amy K. Chesterfield, Mary
C.Wolff, and Christian C. Felder).


16. Coupled Luminescent Methods in Drug Discovery: 3-Min Assays
for Cytotoxicity and Phosphatase Activity (Michael J. Corey and
Robert J. Kinders).


17. Design and Pharmaceutical Applications of Prodrugs (Tomi
Järvinen, Jarkko Rautio, Mar Masson, and Thorsteinn
Loftsson).


18. GABA and Glutamate Receptor Ligands and Their Therapeutic
Potential in CNS Disorders (Ulf Madsen, Hans Bräuner-Osborne,
Jeremy R. Greenwood, Tommy N. Johansen, Povl Krogsgaard-Larsen,
Tommy Liljefors, Mogens Nielsen, and Bente Frølund).


19. Cardiac Sarcolemmal ATP-Sensitive Potassium Channel
Antagonists: Novel Ischemia-Selective Antiarrhythmic Agents (George
E. Billman).


20. Factors Influencing the Efficacy of Mediator-Specific
Anti-Inflammatory, Glucocorticoid, and Anticoagulant Therapies for
Sepsis (Peter C. Minneci, Katherine J. Deans, Michael Haley,
Xizhong Cui, Charles Natanson, and Peter Q. Eichacker).


21. Combinatorial Chemistry in the Drug Discovery Process
(Nathan T. Ross, Brian R. McNaughton, and Benjamin L. Miller).


22. Herbal Medicines and Animal Models of Gastrointestinal
Diseases (C.H. Cho and J.K.S. Ko).


23. Endocrine and Metabolic Agents (Brian L. Furman).


24. Respiratory Viruses (Paul D. Olivo).


25. Strategies in the Design of Antiviral Drugs (Erik De Clercq
and Piet Herdewijn).


26. Protein Kinase Inhibitors in Drug Discovery (Keykavous
Parang and Gongqin Sun).


27. RNA-Based Therapies (Steve Pascolo).


28. Novel Imaging Agents for Molecular MR Imaging of Cancer
(Dmitri Artemov and Zaver M. Bhujwalla).


29. Targets and Approches for Cancer Drug Discovery (Susan L.
Mooberry).


Index.

About the Author

SHAYNE C. GAD, PHD, DABT, ATS, is the Principal of Gad Consulting Services. He has more than twenty-eight years of experience as a toxicologist, statistical consultant, manager, and consultant on research and development in the chemical, consumer product, contract testing, biotechnology, medical device, and pharmaceutical industries. He is the author of twenty-nine books and numerous papers, presentations, and other publications.

Reviews

"...provides in one volume most of the currently used and emerging
technologies available...presents a wealth of information on topics
that are difficult to find elsewhere...a very useful handbook."
(Journal of Medicinal Chemistry, November 2005)
"?will be of great value to medicinal chemists and organic
chemists, pharmacologists, physicians, researchers, and everyone
interested in the development of therapeutic drugs." (Chemical
Educator, September/October 2005)


"...the quality and breadth of the 'Drug Discovery Handbook'
make it indispensable for professionals, and endlessly engaging for
those interested in discovering more about new drugs..." (Kirkus
Reviews, The 2005 Reference Review)


??an authoritative, comprehensive, and
state-of-the-art reference source...thorough coverage and
practical, scientifically valid problem-solving approach make it an
indispensable aid to anyone involved in the complex task of
developing new drugs.? (The Chemical Educator, Vol.
10, No. 5, September/October 2005)