Table of Contents

Foreword--Lawrence F. Marshall, MD.

Preface.

Contributors.

BASIC SCIENCE: OVERVIEW.

Overview of Basic Mechanisms Underlying Neuropathological Consequences of Head Trauma (P. Lezlinger, et al.).

In Vitro Models of Traumatic Brain Injury (B. Pike).

Contemporary In Vivo Models of Brain Trauma and a Comparison of Injury Responses (A. Kline & C. Dixon).

PRECLINICAL STUDIES.

The Role of Glutamate Receptors in the Pathophysiology of Traumatic Brain Injury (M. Temple, et al.).

Cholinergic Receptors in Head Trauma (B. Lyeth).

Adenosine Receptor Activation in Traumatic Brain Injury (P. Kochanek & L. Miller).

Growth Factors (S. Finklestein & A. Plomaritoglou).

The Inflammatory Response as a Therapeutic Target in Traumatic Brain Injury (P. Kochanek, et al.).

Contribution of Ionic Alterations to Metabolic Dysfunction Following Traumatic Brain Injury (A. Samii, et al.).

Contribution of Calpains and Caspases to Cell Death Following Traumatic Brain Injury (R. Hayes, et al.).

Apoptosis and DNA Damage (R. Raghupathi).

Mitochondrial Dysfunction Following Traumatic Brain Injury (Y. Xiong, et al.).

Traumatic Axonal Injury (J. Povlishock & J. Stone).

Vascular Aspects of Severe Head Injury (M. Zwienenberg & J. Muizelaar).

CLINCIAL DIRECTIONS.

Epidemiology and Economics of Head Trauma (D. Thurman).

Clinical Presentation and Neuropsychological Sequelae of Traumatic Brain Injury (S. Brown & H. Levin).

The American Brain Injury Consortium (T. Marmarou).

Guidelines for Medical and Surgical Management in Head Trauma Patients in the United States and Europe (D. d'Avella & G. Tomei).

Clinical Trials in Head Injury: United States (P. Muizelaar & L. Miller).

Clinical Trials in Head Injury: Europe (A. Maas).

Clinical Trials in Head Injury: Asia (S. Maejima & Y. Katayama).

Appendix.

Index.

About the Author

Leonard P. Miller is the author of Head Trauma: Basic, Preclinical, and Clinical Directions, published by Wiley.

Reviews

"a valuable addition to the reading of those involved in traumatic brain injury." (Journal of Neurology, Neurosurgery & Psychiatry, No. 72, 2002)