Table of Contents

SECTION I: PHARMACOLOGY 1 1 Pharmacokinetics and Pharmacodynamics of Injected and Inhaled Drugs 3 2 Inhaled Anesthetics 42 3 Opioid Agonists and Antagonists 87 4 Barbiturates 127 5 Benzodiazepines 140 6 Nonbarbiturate Intravenous Anesthetic Drugs 155 7 Local Anesthetics 179 8 Neuromuscular-Blocking Drugs 208 9 Anticholinesterase Drugs and Cholinergic Agonists 251 10 Anticholinergic Drugs 266 11 Cyclooxygenase-2 Inhibitors and Nonspecific Nonsteroidal Antiinflammatory Drugs 276 12 Sympathomimetics 292 13 Digitalis and Related Drugs 311 14 Alpha- and Beta-Adrenergic Receptor Antagonists 321 15 Antihypertensive Drugs 338 16 Peripheral Vasodilators, Nitric Oxide, and Nitrovasodilators 352 17 Cardiac Antidysrhythmic Drugs 370 18 Calcium-Channel Blockers 387 19 Drugs Used for Psychopharmacologic Therapy 398 20 Prostaglandins 420 21 Histamine and Histamine Receptor-Antagonists 429 22 Serotonin, Plasma Kinins, and Renin 444 23 Hormones as Drugs 456 24 Insulin and Oral Hypoglycemics 477 25 Diuretics 486 26 Antacids and Gastrointestinal Prokinetics 496 27 Anticoagulants 505 28 Antimicrobials 521 29 Chemotherapeutic Drugs 551 30 Antiepileptic Drugs 569 31 Drugs Used for Treatment of Parkinson Disease 580 32 Drug Treatment of Lipid Disorders 585 33 Central Nervous System Stimulants and Muscle Relaxants 591 34 Vitamins, Dietary Supplements, and Herbal Remedies 599 35 Minerals and Electrolytes 611 36 Blood Components, Substitutes and Hemostatic Drugs 623 37 Enteral and Parenteral Nutrition 635 38 Antiseptics and Disinfectants 640 SECTION II: PHYSIOLOGY 645 39 Cell Structure and Function 647 40 Body Fluids 658 41 Central Nervous System 663 42 Thermoregulation 668 43 Autonomic Nervous System 696 44 Pain 707 45 Systemic Circulation 718 46 Microcirculation and Lymphatics 735 47 Pulmonary Circulation 741 48 Heart 749 49 The Electrocardiogram and Analysis of Cardiac Dysrhythmias 761 50 The Lungs 771 51 Pulmonary Gas Exchange and Blood Transport of Gases 783 52 Acid-Base Balance 794 53 Endocrine System 803 54 Kidneys 817 55 Liver and Gastrointestinal Tract 831 56 Skeletal and Smooth Muscle 844 57 Erythrocytes and Leukocytes 849 58 Hemostasis and Blood Coagulation 859 59 Metabolism of Nutrients 863 60 Physiology of the Newborn and Elderly 871 Drug Index 883 Subject Index 000