Table of Contents

Chemistry, Biochemistry, and Cell Biology

An Overview on Lipoate Chemistry, Gerreke Ph. Biewenga, Guido R. M. M. Haenen, and Aalt Bast
Lipoate Redox Function in Chemical Systems, Wolf Bors and Christa Michel
Reaction of Lipoate and Its Derivatives with Reactive Oxygen Species, Sergey Dikalov, Valery V. Khramtsov, and Guido Zimmer
Overview of the Role of Lipoate in the Enzyme Complexes of Energy Metabolism and Reducing Equivalents, Guido Zimmer
Alpha-Lipoic Acid Stimulates Glucose Transport into Muscle and Adipose Cells in Culture: Comparison with the Actions of Insulin and Dinitrophenol, Theodoros Tsakiridis, H. Stephen Ewart, Toolsie Ramlal, Allen Volchuk, Elizabeth D. Estrada, Hans J. Tritschler, and Amira Klip
Lipoic Acid and the Redox Regulation of Apoptosis, Juanita Bustamante, Andrew F. G. Slater, and Sten Orrenius
Lipoate Modulation of Lymphocyte Cystine Uptake, K. Kis, T. Meier, G. Multhoff, and Rolf Dieter Issels
Lipoate Effects in an Animal-Free Model, Niels-Peter Luepke, Gabriele Baron-Ruppert, Holger Meier, and Thorsten Wolf

Pathophysiological Conditions

Tissue-Specific Pathways of a-Lipoate Reduction in Mammalian Systems, Nobuya Haramaki and Garry J. Handelman
a-Lipoate: Antioxidant Properties and Effects on Skin, Maurizio Podda, Maret G. Traber, and Lester Packer
Suppression of Radiation-Induced Free Radical-Mediated Cellular Damage by Lipoate, Ludmila G. Korkina and Igor B. Alfanas'ev
Protection from Myocardial Ischemia Reperfusion Injury, Guido Zimmer
Neuroprotective Activity of Lipoic and Dihydrolipoic Acid, P. Wolz and Josef Krieglstein
Alpha-Lipoic Acid and Cataract Risk Reduction, John R. Trevithick
Metabolic Alterations in Non-Insulin-Dependent Diabetes Mellitus, Stephan Jacob and Erik J. Henriksen
Altered 14C-Deoxyglucose Incorporation in Rat Brain Following Treatment with -Lipoic Acid, Peter Jenner, T. A. Seaton, and C. D. Marsden
Effect of -Lipoic Acid on Muscle Glucose Transporters in Streptozotocin-Induced Diabetic Rats, Mogher Khamaisi, Assaf Rudich, and Nava Bashan
Lipoate Effects in an Animal Model of Insulin Resistance: The Obese Zucker Rat, Erik J. Henriksen
Lipoate Treatment of Toxic Polyneuropathy, H. Altenkirch, G. Stoltenburg-Didinger, H. M. Wagner, J. Herrmann, and G. Walter
-Lipoic Acid Treatment of Peripheral Nerve Disease, Phillip A. Low, Kim K. Nickander, and Hans J. Tritschler
Lipoate Effects on Artherogenesis, Michael Hofmann, Hans J. Tritschler, A. Bierhaus, R. Ziegler, P. Wahl, and P. Nawroth

Medical Applications

Human Pharmacokinetics of -Lipoic Acid, Robert Hermann and G. Niebch
Free Radicals and the Design of Antioxidants: Implications for the Use of Lipoic Acid in Diabetes Treatment, Barry Halliwell
Thioctic Acid: A Potential Modulator of Insulin Sensitivity and Glucose Metabolism in Patients with Type II Diabetes, Stephan Jacob, H. J. Augustin, and G. J. Dietze
Thioctic Acid Stimulates Muscle ATP Production in Patients wtih Type II Diabetes and Diabetic Polyneuropathy, Hans J. Tritschler, Bruno Barbiroli, R. Medori, S. Lotti, R. Lodi, and P. Zaniol
Treatment with -Lipoic Acid in Diabetic Peripheral and Cardiac Autonomic Neuropathy, Dan Ziegler and F. Arnold Gries
Lipoate Prevention of Diabetic Microangiopathy, Michael Hofmann and Guido Zimmer
Lipoate Prevention of Diabetic Microangiopathy, Klaus Kusterer, E. Haak, H. Ulrich, and T. Haak
Redox Modulation of Signal Transduction and Gene Expression in HIV Infection: The Role of the Antioxidant Lipoate, Jürgen Fuchs and Helmut Schöfer
The Effects of Lipoate on Free Radical Production by the Phagocytes from Humans and Animals Under Oxidative Stress, Igor B. Afanas'ev, Ilya I. Afanas'ev, and Ludmila G. Korkina

About the Author

Fuchs; Jurgen Johann Wolfgang Goethe Universitat, Frankfurt, Germany,