Table of Contents

Foreword Preface GENERAL PRINCIPLES 1. Historical Background and Overview A. Varki and N. Sharon 2. Structural Basis of Glycan Diversity C.R. Bertozzi and D. Rabuka 3. Cellular Organization of Glycosylation A. Varki, J.D. Esko, and K.J. Colley 4. Glycosylation Precursors H.H. Freeze and A.D. Elbein 5. Glycosyltransferases and Glycan-processing Enzymes J.M. Rini, J.D. Esko, and A. Varki 6. Biological Roles of Glycans A. Varki and J.B. Lowe 7. A Genomic View of Glycobiology B. Henrissat, A. Surolia, and P. Stanley STRUCTURE AND BIOSYNTHESIS 8. N-Glycans P. Stanley, H. Schachter, and N. Taniguchi 9. O-GalNAc Glycans I. Brockhausen, H. Schachter, and P. Stanley 10. Glycosphingolipids R.L. Schnaar, A. Suzuki, and P. Stanley 11. Glycosylphosphatidylinositol Anchors M.A.J. Ferguson, T. Kinoshita, and G.W. Hart 12. Other Classes of ER/Golgi-derived Glycans H.H. Freeze and R.S. Haltiwanger 13. Structures Common to Different Glycans P. Stanley and R.D. Cummings 14. Sialic Acids A. Varki and R. Schauer 15. Hyaluronan V. Hascall and J.D. Esko 16. Proteoglycans and Sulfated Glycosaminoglycans J.D. Esko, K. Kimata, and U. Lindahl 17. Nucleocytoplasmic Glycosylation G.W. Hart and C.M.West 18. The O-GlcNAc Modification G.W. Hart and Y. Akimoto ORGANISMAL DIVERSITY 19. Evolution of Glycan Diversity A. Varki, H.H. Freeze, and P. Gagneux 20. Eubacteria and Archaea J.D. Esko, T.L. Doering, and C.R.H. Raetz 21. Fungi R.D. Cummings and T.L. Doering 22. Viridiplantae M.E. Etzler and D. Mohnen 23. Nematoda R.D. Cummings and J.D. Esko 24. Arthropoda M. Tiemeyer, S.B. Selleck, and J.D. Esko 25. Deuterostomes H.H. Freeze, V.D. Vacquier, and J.D. Esko GLYCAN-BINDING PROTEINS 26. Discovery and Classification of Glycan-binding Proteins A. Varki, M.E. Etzler, R.D. Cummings, and J.D. Esko 27. Principles of Glycan Recognition R.D. Cummings and J.D. Esko 28. R-type Lectins R.D. Cummings and M.E. Etzler 29. L-type Lectins M.E. Etzler, A. Surolia, and R.D. Cummings 30. P-type Lectins A. Varki and S. Kornfeld 31. C-type Lectins R.D. Cummings and R.P. McEver 32. I-type Lectins A. Varki and P.R. Crocker 33. Galectins R.D. Cummings and F.-T. Liu 34. Microbial Lectins: Hemagglutinins, Adhesins, and Toxins J.D. Esko and N. Sharon 35. Proteins that Bind Sulfated Glycosaminoglycans J.D. Esko and R.J. Linhardt GLYCANS IN PHYSIOLOGY AND DISEASE 36. Glycans in Glycoprotein Quality Control H.H. Freeze, J.D. Esko, and A.J. Parodi 37. Free Glycans as Signaling Molecules M.E. Etzler and J.D. Esko 38. Glycans in Development and Systemic Physiology A. Varki, H.H. Freeze, and V.D. Vacquier 39. Bacterial and Viral Infections V. Nizet and J.D. Esko 40. Parasitic Infections R.D. Cummings and S. Turco 41. Genetic Disorders of Glycan Degradation H.H. Freeze 42. Genetic Disorders of Glycosylation H.H. Freeze and H. Schachter 43. Glycans in Acquired Human Diseases A. Varki and H.H. Freeze 44. Glycosylation Changes in Cancer A. Varki, R. Kannagi, and B.P. Toole METHODS AND APPLICATIONS 45. Antibodies and Lectins in Glycan Analysis R.D. Cummings and M.E. Etzler 46. Glycosylation Mutants of Cultured Cells J.D. Esko and P. Stanley 47. Structural Analysis of Glycans B. Mulloy, G.W. Hart, and P. Stanley 48. Glycomics C.R. Bertozzi and R. Sasisekharan 49. Chemical and Enzymatic Synthesis of Glycans and Glycoconjugates P.H. Seeberger, N. Finney, D. Rabuka, and C.R. Bertozzi 50. Chemical Tools for Inhibiting Glycosylation J.D. Esko and C.R. Bertozzi 51. Glycans in Biotechnology and the Pharmaceutical Industry C.R. Bertozzi, H.H. Freeze, A. Varki, and J.D. Esko Glossary Study Guide Index

Reviews

Advance praise:A"The basic principles of glycobiology are clearly articulated in this volume, and the roles of complex carbohydrates in disease are an important read for all biomedical scientists.A"-Peter Agre, M.D., Nobel Laureate in Chemistry, 2003A"Essentials of Glycobiology is a major resource for understanding these post-translational biochemical reactions that affect the function and fate of proteins produced by the genes that are profoundly changed by their added sugars.A"-Baruch S. Blumberg, Nobel Laureate in Medicine, 1976A"The second edition of Essentials of Glycobiology, superbly printed and illustrated, develops in simple and absolutely precise terms the complicated intricacies of glycobiology. I would have killed to get this encyclopedic treatise 40 years ago when I was working my way through this field.A"-Edmond H. Fischer, Nobel Laureate in Medicine, 1992