Table of Contents

Section I: Principles of Laboratory Medicine



Introduction to Laboratory Medicine
Selection and Analytical Evaluation of Methods�- With Statistical Techniques
Clinical Evaluation of Methods
Evidence Based Laboratory Medicine
Establishment and Use of Reference Values
Preanalytical Variables and Biological Variation
Specimen Collection and Processing
Quality Management
Section II: Analytical Techniques and Instrumentation

Principles of Basic Techniques and Laboratory Safety
Optical Techniques
Electrochemistry and Chemical Sensors
Electrophoresis
Chromatography and Extraction
Mass Spectrometry
Enzyme and Rate Analyses
Principles of Immunochemical Techniques
Nucleic Acid Techniques
Microfabrication and Microfluidics and Their Application to Clinical Diagnostics
Automation in the Clinical Laboratory
Point-of-Care Testing
Section III: Analytes

Amino Acids, Peptides, and Proteins
Serum Enzymes
Enzymes of the Red Blood Cell
Tumor Markers
Kidney Function Tests
Carbohydrates
Lipids, Lipoproteins, Apolipoproteins, and Other Cardiovascular Risk Factors
Electrolytes and Blood Gases
Hormones
Catecholamines and Serotonin
Vitamins and Trace Elements
Hemoglobin, Iron, and Bilirubin
The Porphyrias and Other Disorders of Porphyrin Metabolism
Therapeutic Drugs and Their Management
Clinical Toxicology
Toxic Metals
Section IV: Molecular Diagnostics and Genetics

Principles of Molecular Biology
Genomes and Nucleic Acid Alterations
Nucleic Acid Isolation
Inherited Diseases
Identity Assessment
Molecular Methods in Diagnosis and Monitoring of Infectious Diseases
Pharmacogenetics
Hematopoietic Malignancies
Plasma Nucleic Acids
Section V: Pathophysiology

Diabetes Mellitus
Cardiovascular Disease
Kidney Disease
Physiology and Disorders of Water, Electrolyte, and Acid-Base Metabolism
Liver Disease
Gastrointestinal and Pancreatic Diseases
Disorders of Bone and Mineral Metabolism
Pituitary Function and Pathophysiology
The Adrenal Cortex
The Thyroid: Pathophysiology and Thyroid Function Testing
Reproductive Endocrinology and Related Disorders
Pregnancy and its Disorders
Newborn Screening and Inborn Errors of Metabolism
Hemostasis
Section VI: Appendix

Reference Information for the Clinical Laboratory