Table of Contents

I. LUNG

A. Normal Lung

Development of Lung

Normal Lung

B. Incidental Findings

Meningothelioid (Meningothelial-Like/Meningothelial) Nodule

Osseous Metaplasia

Corpora Amylacea

C. Developmental and Pediatric Diseases

Pulmonary Hypoplasia

Congenital Pulmonary Airway Malformation (CPAM)

Pulmonary Sequestration

Bronchogenic Cyst

Peripheral Lung Cysts

Infantile (Congenital) Lobar Emphysema

Interstitial Pulmonary Emphysema (IPE)

Congenital Pulmonary Lymphangiectasis

Alveolar Capillary Dysplasia

Surfactant Dysfunction Disorders

Hyaline Membrane Disease

Bronchopulmonary Dysplasia (BPD)

Pulmonary Interstitial Glycogenosis (PIG)

Chronic Granulomatous Disease (CGD) Of Childhood

D. Pediatric Tumors

Pleuropulmonary Blastoma

Inflammatory Myofibroblastic Tumor (IMT)

Congenital Pulmonary Myofibroblastic Tumor

Metastatic Pediatric Tumors

E. Obstructive Lung (Airway) Diseases

Large Airway Diseases

Bronchiectasis

Cystic Fibrosis

Chronic Bronchitis

Asthma

Allergic Bronchopulmonary Aspergillosis

Small Airway Diseases and Emphysema

Acute Bronchiolitis

Chronic Bronchiolitis

Follicular Bronchiolitis

Bronchiolitis Obliterans/Constrictive Bronchiolitis Obliterans/Constrictive Bronchiolitis

Emphysema

F. Restrictive (Interstitial) Lung Diseases

Acute Restrictive Lung Diseases

Pulmonary Edema

Acute Lung Injury, Acute Respiratory Distress Syndrome, Diffuse Alveolar Damage

Acute Interstitial Pneumonia (AIP)

Chronic Restrictive Lung Diseases

Usual Interstitial Pneumonia (UIP)

Nonspecific Interstitial Pneumonia (NSIP)

Cryptogenic Organizing Pneumonia (COP)

IgG4-related Sclerosing Disease

Rheumatoid Arthritis (RA)

Systemic Lupus Erythematosus (SLE)

Scleroderma

Polymyositis and Dermatomyositis-Associated Lung Disease

Sjögren Syndrome

Inflammatory Bowel Disease-Associated Interstitial Lung Disease

Asbestosis

Silicosis

Coal Workers' Pneumoconiosis (CWP)

G. Granulomatous Diseases (non-infectious)

Sarcoidosis

Hypersensitivity Pneumonitis or Extrinsic Allergic Alveolitis

Aspiration Pneumonitis

H. Smoking Related Diseases

Desquamative Interstitial Pneumonia (DIP)

Respiratory Bronchiolitis-Associated Interstitial Lung Disease (RB-ILD)

Langerhans Cell Histiocytosis (LCH)

I. Miscellaneous Diseases

Pulmonary Alveolar Proteinosis (PAP)

Pulmonary Amyloidosis

Eosinophilic Pneumonia

Lipoid Pneumonia

Lymphangioleiomyomatosis

Middle Lobe Syndrome (Right Middle Lobe Syndrome)

Acute Chest Syndrome Of Sickle Cell Disease

Intravenous Drug Abuse

J. Diseases of Vascular Origin

Pulmonary Embolism and Infarction

Arteriovenous Malformation of the Lung

Pulmonary Hypertension

Pulmonary Hypertension

Pulmonary Arterial Hypertension (PAH)

Pulmonary Veno-Occlusive Disease (PVOD)

Pulmonary Capillary Hemangiomatosis (PCH)

Chronic Thromboembolic Pulmonary Hypertension

Pulmonary Hypertension Associated with Lung Diseases Or Hypoxemia

Diffuse Pulmonary Hemorrhage Syndromes

Goodpasture Syndrome: Anti Glomerular Basement Membrane Antibody Disease

Idiopathic Pulmonary Hemosiderosis (IPH)

Vasculitis

Pulmonary Wegener Granulomatosis

Pulmonary Churg-Strauss Syndrome

K. Pulmonary Infections

Non-infectious Pulmonary Lesions in HIV/AIDS patients

Bacterial Pneumonias

Lobar Pneumonia and Bronchopneumonia

Aspiration Pneumonia

Tuberculosis

Atypical Mycobacterial Infection

Actinomycosis

Nocardiosis

Legionnaires' Disease

Lung Abscess

Viral Pneumonia

Lymphocytic Pneumonia

Cytomegalovirus (CMV) Pneumonia

Herpes Simplex Virus (HSV) Pneumonia

Adenovirus Pneumonia

Respiratory Syncytial Virus (RSV) Pneumonia

Measles Pneumonia

Human Metapneumovirus Pneumonia

H1N1 Pneumonia

Severe Acute Respiratory Syndrome (SARS)

Fungal Pneumonia

Aspergillosis

Blastomycosis

Candidiasis

Coccidioidomycosis

Cryptococcosis

Histoplasmosis

Pneumocystis Pneumonia (PCP)

Zygomycosis

L. Complications of Therapies

Drug-Induced Lung Injury

Methotrexate

Amiodarone

Bleomycin

Cyclophosphamide

Radiation Therapy

Radiation Pneumonitis

Bacterial Pneumonias

Lung Transplantation

Lung Transplantation: Acute Rejection

Lung Transplantation: Chronic Rejection (Bronchiolitis Obliterans)

Graft versus Host Disease (GVHD) And Other Complications of Transplantation in the Lung

M. Tumors of Lung

TNM Classification of Primary Non-Small Cell Carcinoma, Small Cell Carcinoma, and Carcinoid Tumor of the Lung

Benign tumors

Squamous Papilloma

Squamous Papillomatosis

Hamartoma

Chondroma

Pneumocytoma (Sclerosing Hemangioma)

Lipoma of Lung

Pulmonary Leiomyoma

Granular Cell Tumor

Lymphangioma and Lymphangiomatosis

Rare Benign Tumors of the Lung

Epithelial Proliferations and Tumors

Airway Epithelial Hyperplasia/Metaplasia

Squamous Dysplasia and Carcinoma In Situ (CIS)

Atypical Adenomatous Hyperplasia (AAH)

Adenocarcinoma In Situ (AIS), Formerly Bronchioloalveolar Carcinoma (BAC)

Adenocarcinoma

Squamous Cell Carcinoma (SCC)

Papillary Variant of Squamous Cell Carcinoma

Clear Cell Variant of Squamous Cell Carcinoma

Small Cell Variant of Squamous Cell Carcinoma

Basaloid Variant of Squamous Cell Carcinoma

Alveolar Space-Filling Type of Peripheral Squamous Cell Carcinoma

Lymphoepithelioma-Like Carcinoma

Adenosquamous Carcinoma

Large Cell Carcinoma

Sarcomatoid Carcinoma

Pleomorphic Carcinoma

Spindle Cell Carcinoma

Giant Cell Carcinoma

Carcinosarcoma

Pulmonary Blastoma

Adenoid Cystic Carcinoma

Mucoepidermoid Carcinoma

Epithelial-Myoepithelial Carcinoma

Neuroendocrine Proliferations and Tumors

Diffuse Neuroendocrine Cell Hyperplasia

Carcinoid Tumorlet

Carcinoid Tumor

Typical Carcinoid

Atypical Carcinoid

Small Cell Carcinoma

Large Cell Neuroendocrine Carcinoma

Mesenchymal Tumors

Solitary Fibrous Tumor of Lung

Kaposi Sarcoma

Epithelioid Hemangioendothelioma

Pulmonary Synovial Sarcoma (SS)

Pulmonary Artery and Vein Sarcoma

Rhabdomyosarcoma Lung

Miscellaneous Tumors

Perivascular Epithelioid Cell tumor (PEComa, Clear Cell "Sugar" Tumor) of the Lung

Primary Pulmonary Malignant Melanoma (PPMM)

Lymphoproliferative Disorders

Extranodal Marginal Zone B-Cell Lymphoma of Bronchial-Associated Lymphoid Tissue

Lymphoid Interstitial Pneumonia (Diffuse Lymphoid Hyperplasia)

Post-Transplant Lymphoproliferative Disorders (PTLD)

Diffuse Large B-cell lymphoma (DLBCL) of the Lung

Primary Pulmonary Hodgkin Lymphoma (PPHL)

Lymphomatoid Granulomatosis

Primary Pulmonary (Extraosseous) Plasmacytoma

Metastatic Tumors

Metastases to the Lungs: Introduction

Metastatic Carcinomas

Metastatic Carcinomas: Breast and Female Genital Tract

Metastatic Carcinomas: Gastrointestinal Tract

Metastatic Carcinomas: Genitourinary Tract and Adrenal

Metastatic Carcinomas: Head and Neck

Metastatic Adult Sarcomas

Benign Metastasizing Leiomyoma (BML)

Metastatic Giant Cell Tumor

Metastatic Melanoma

II. PLEURA AND PERICARDIUM

A. Non-Neoplastic Diseases

Pleuritis

Mesothelial hyperplasia

Adenomatoid Tumor of the Pleura

B. Neoplastic Diseases

TNM Classification of Pleural Mesothelioma

Well Differentiated Papillary Mesothelioma (WDPM)

Malignant Mesothelioma of Pleura

Epithelioid Malignant Mesothelioma

Sarcomatoid Malignant Mesothelioma

Desmoplastic Malignant Mesothelioma

Biphasic Malignant Mesothelioma

Solitary Fibrous Tumor of Pleura and Pericardium

Calcifying Pseudotumor of Pleura/Calcifying Fibrous Pseudotumor

Pleural Synovial Sarcoma

Primitive Neuroectodermal Tumor/Skeletal Ewing Sarcoma

Desmoplastic Small Round Cell Tumor of Pleura (DSRCT)

Primary Effusion Lymphoma (PEL)

Metastases to Pleura

III. THYMUS

A. Normal Thymus

Normal Thymus

B. Non-Neoplastic Diseases

Unilocular and Multilocular Thymic cysts

Thymic Dysplasia

Acute Involution of Thymus (Stress-Induced Thymic Involution)

True Thymic Hyperplasia

Lymphoid Hyperplasia of the Thymus

C. Thymoma

General Features of Thymoma

WHO Type A Thymoma

WHO Type AB Thymoma

WHO Type B1 Thymoma

WHO Type B2 Thymoma

WHO Type B3 Thymoma

D. Other Thymic Tumors

Thymic Carcinoma

Thymic Neuroendocrine Carcinoma/Tumors

Thymolipoma

IV. MEDIASTINAL LESIONS

A. Inflammatory infectious lesions

Mediastinitis

B. Cystic lesions

Mediastinal Bronchogenic Cyst

Esophageal Cyst

Mediastinal Gastroenteric Cyst

Pericardial Cyst

C. Ectopic lesions

Mediastinal Ectopic Thyroid

Ectopic Parathyroid

D. Tumors

Neurogenic Tumors

Mediastinal Schwannoma (neurilemmoma)

Mediastinal Neurofibroma

Mediastinal Malignant Peripheral Nerve Sheath Tumor (MPNST)

Neuroblastic Tumors

Mediastinal Neuroblastoma

Mediastinal Ganglioneuroblastoma

Mediastinal Ganglioneuroma

Mediastinal Paraganglioma

Mediastinal Paraganglioma

Germ Cell Tumors

Germ Cell Tumors of Mediastinum

Lymphoproliferative Disorders

Hodgkin Lymphoma of the Mediastinum

Mediastinal T-Lymphoblastic Lymphoma (T-LBL)

Primary Mediastinal (Thymic) Large B-Cell Lymphoma (PMLBCL)

Anaplastic Large Cell Lymphoma of Mediastinum

Myeloid Sarcoma (MS)

Mediastinal Castleman Disease (CD)

Follicular Dendritic Cell (FDC) Sarcoma

Mesenchymal Tumors

Mediastinal Lymphangioma

Mediastinal Liposarcoma

Rhabdomyosarcoma

V. HEART AND VESSELS

A. Normal Heart

Normal Heart

B. Congenital Heart Disease

Atrial Septal Defect (ASD)

Ventricular Septal Defect (VSD)

Hypoplastic Left Heart Syndrome (HLHS)

Tetralogy of Fallot

C. Valvular Diseases

Degenerative Valvular Disease

Bicuspid Aortic Valve (BAV)

Aortic Valve Stenosis

Aortic Valve Insufficiency

Mitral Valve Stenosis

Mitral Valve Regurgitation

Prosthetic Valves

Endocarditis

Infectious Endocarditis

Nonbacterial Thrombotic Endocarditis (NBTE)

Rheumatic Heart Disease

Acute Rheumatic Fever and Rheumatic Heart Disease (RHD)

D. Myocardial Diseases

Lymphocytic Myocarditis

Eosinophilic Myocarditis

Giant Cell Myocarditis

Cardiac Amyloidosis (Amyloid Cardiomyopathy)

Cardiac Sarcoidosis

Dilated Cardiomyopathy

Hypertrophic Cardiomyopathy

Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy

Cardiac Hemochromatosis

Hypertensive Heart Disease

Drug Cardiotoxicity

E. Ischemic Heart Disease

Myocardial Infarction (MI)

F. Heart Transplantation

Heart Transplantation: Introduction

Antibody Mediated Rejection of the Heart

Acute Cellular Rejection of the Heart

Chronic Rejection of the Heart (Cardiac Allograft Vasculopathy)

Quilty Lesion

G. Infections

Opportunistic Cardiac Infections

H. Tumors of the heart

Benign tumors

Cardiac Myxoma

Cardiac Rhabdomyoma

Cardiac Fibroelastoma

Cardiac Fibroma

Cardiac Hemangioma

Cardiac Lipoma

Lipomatous Hypertrophy of the Interatrial Septum

Malignant tumors

Angiosarcoma of the Heart

Synovial Sarcoma of the Heart

Rare Cardiac sarcomas

Primary Cardiac Lymphoma (PCL)

Cardiac Metastasis

I. Diseases of Vessels

Atherosclerosis

Thoracic Aortic aneurysm

Aortic Dissection

Infectious Vasculitis

Giant Cell Arteritis

Takayasu Arteritis

Kawasaki Disease

Churg-Strauss Syndrome

Polyarteritis Nodosa

Microscopic Polyangiitis

Thromboangiitis Obliterans

Wegener Granulomatosis

Reviews

"This is a very useful book for surgical pathologists or pathology residents. It is intended to be a quick reference with numerous useful photomicrographs. This book serves this purpose well and would be a practical addition to a pathologist's library." - Natalie M Webster, MD(University of Kansas Medical Center)