Table of Contents

I. Preface

1. Nomenclature (C. Dugave)

2. General Mechnanisms of Cis-Trans Isomerization (C. Dugave)

3. Mechanisms of Cis-Trans Isomerization araound the Carbon-Carbon Double Bonds via the Triplet State (Y. Koyoma, Y. Kakitani, H. Nagae)

4. Retinal Binding Proteins (I. Kandori)

5. Non-Retinal Chromophoric Proteins (M. Zimmer)

6. Fatty Acids and Phospholipids (C. Chatgilialoglu,* C. Ferreri)

7. In Silico Dynamic Studies of CTI in Organic and Biological Systems (U. Röhrig, I. Tavernelli, U. Rothlisberger*)

8. Chemical Aspects of the Restricted Rotation of Amide and Analogs (C. Dugave)

9. Amide Cis-Trans Isomerization in Peptides and Proteins (S. Wawra, G. Fischer)

10. Enzymes Catalyzing Cis-Trans Isomerization (G. Fischer)

11. Tailoring the Cis-Trans Isomerization of Amides (M. Mutter, L. Moroder)

12. PPIases: New Targets for Novel Therapeutics? (C. Dugave)

13. Other Cis-Trans Isomerisms in Peptides and Proteins (M. Gondry, C. Dugave)

14. Cis-Trans Isomerism in Metal Complexes (A. A. Batista)

About the Author

Christophe Dugave prepared his PhD in molecular pharmacology under the guidance of Professor Marquet and Professor Gaudry. Then he moved to the University of Sherbrooke (Canada) where he worked as a post-doctoral fellow under the supervision of Professor Deslongchamps. He is currently working at the Department of Protein Engineering and Research of the French Atomic Energy Commission at CEA/Saclay near Paris. His research interests include the synthesis of nonnatural amino acids, pseudopeptides, peptidomimetics, and radiolabeling of peptides and proteins with tritium technetium and other radioisotopes.