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Table of Contents

1 Evolution of Concepts of Mechanisms of Sleep.- 2 Principles of Sleep Regulation: Implications for the Effect of Hypnotics on Sleep.- 3 Principles of Chronopharmacology and the Sleep-Wake Rhythm.- 4 Pharmacology of the Catecholaminergic System.- 5 The Serotoninergic System and Sleep-Wakefulness Regulation.- 6 Pharmacology of the Histaminergic System.- 7 Pharmacology of the Cholinergic System.- 8 Pharmacology of the GABAergic/Benzodiazepine System.- 9 Pharmacology of the CNS Peptides.- 10 Hormones and Sleep.- 11 Pharmacology of the Adenosine System.- 12 Methodological Issues in Pharmacological Studies of Sleep.- 13 Hypnotic Drugs.- 14 Anxiolytic Drugs.- 15 Stimulant Drugs.- 16 Neuroleptics, Antihistamines and Antiparkinsonian Drugs: Effects on Sleep.- 17 Antidepressant and Antimanic Drugs.- 18 Anticonvulsant Drugs.- 19 Mechanisms of Benzodiazepine Drug Dependence.- 20 Sleep Disturbances as Side Effects of Therapeutic Drugs.