Table of Contents

Introduction (Camille G. Wernuth and P. Heinrich Stahl). Chapter 1: The Physicochemical Background: Fundamentals of Ionic Equilibria (Michael B. Maurin, David J. W. Grant and P. Heinrich Stahl). Chapter 2: Solubility and Dissolution of Weak Acids, Bases, and Salts (Madhu Pudipeddi, Abu T. M. Serajuddin, David J. W. Grant and P. Heinrich Stahl). Chapter 3: Evaluation of Solid-State Properties of Salts (Danielle Giron and David J. W. Grant). Chapter 4: Pharmaceutical Aspects of the Drug Salt Form (P. Heinrich Stahl and Masahiro Nakano). Chapter 5: Biological Effects of the Drug Salt Form (Friedlieb Pfannkuch, Harald Rettig, and P. Heinrich Stahl). Chapter 6: Salt-Selection Strategies (Abu T. M. Serajuddin and Madhu Pudipeddi). Chapter 7: A Procedure for Salt Selection and Optimization (Michael J. Bowker). Chapter 8: Large-Scale Aspects of Salt Formation: Processing of Intermediates and Final Products (Stanley Lee and Christian Hoff). Chapter 9: Patent Aspects of Drug Salt Formation (Hans-GA nther Foraita). Chapter 10: Regulatory Aspects of Drug Salts (Henning Asche, Jun-ichi Kondo, and Funmilayo O. Ajayi). Chapter 11: Selected Procedures for the Preparation of Pharmaceutically Acceptable Salts (Camille G. Wermuth and P. Heinrich Stahl). Chapter 12: Monographs on Acids and Bases (P. Heinrich Stahl and Camille G. Wermuth). Appendix (P. Heinrich Stahl). Subject-Index. Substance-Index.

Reviews

"...the editors have produced a rare commodity, a body of knowledge on an important area, summarized in single volume.In a nutshell, this long-overdue volume belongs on the personal shelf of every pharmaceutical scientist working with new chemical entities." Pharmaceutical Development and Technology