Table of Contents

Early studies; the phase problem; from the first molecular model to the allosteric mechanism; the haemoglobin wars; molecular pathology of human haemoglobin; haemoglobin as a drug receptor; species adaptations in haemoglobin; early shots at the folding problem and factors contributing to protein stability; polar zippers and human disease; haemoglobin as an oxygen sensor that regulates expression of nitrogenase genes.