Dedication.- About the editors.- Preface (Jarvis JUM).- Chapter 1. Social evolution in African mole-rats - a comparative overview (Faulkes CG & Bennett NC).- Chapter 2. Social behavior in naked mole-rats: individual differences in phenotype and proximate mechanisms of mammalian eusociality (Holmes MM & Goldman BD).- Chapter 3. Neuropeptidergic and neuroendocrine systems underlying eusociality and the concomitant social regulation of reproduction in naked mole-rats: a comparative approach (Coen CW, Bennett N, Holmes MM, & Faulkes CG).- Chapter 4. Adult neural plasticity in naked mole-rats: implications of fossoriality, longevity and sociality on the brain’s capacity for change (Mooney SJ, Forger NG, & Holmes MM).- Chapter 5. Sensory Systems of the African Naked Mole-Rat (Vice EN, Lagestee S, Browe BM, Deb D, Smith ESJ, Park TJ).- Chapter 6. Hearing and vocalizations in the naked mole-rat (Barker AJ, Koch, U, Lewin GR, Pyott, SJ).- Chapter 7. The somatosensory world of the African naked mole-rat (Lewin GR, Smith ESJ, Reznick J, Debus K, Barker A, and Park TJ).- Chapter 8. The idiosyncratic physiological traits of the naked mole-rat; a resilient animal model of aging, longevity, and healthspan (Buffenstein R and Craft W).- Chapter 9. African Naked Mole-Rats Demonstrate Extreme Tolerance to Hypoxia and Hypercapnia (Park TJ, Smith ESJ, Reznick J, Bennett NC, Applegate DT, Larson J, Lewin GR).- Chapter 10. A sweet story of metabolic innovation in the naked mole-rat (Reznick J, Park TJ, and Lewin GR).- Chapter 11. Insights into the molecular basis of genome stability and pristine proteostasis in naked mole-rats (Narayan V, McMahon M, O’Brien J, McAllister F and Buffenstein R).- Chapter 12. The Unusual Immune System of the Naked Mole-Rat (Lin TD and Buffenstein R).- Chapter 13.- Induced Pluripotent Stem Cells from Cancer-Resistant Naked Mole-rats (Miura. K, Oiwa Y, and Kawamura Y).- Chapter 14. Naked mole-rats: resistant to developing cancer or good at avoiding it? (HadiF, Smith ESJ and Khaled WT).- Chapter 15. Spontaneous Disease and Pathology of Naked Mole-rats (Delaney MA, Imai DM, Buffenstein R).- Chapter 16. Managed Care of Naked Mole-rats (Smith M, and Buffenstein¬ R).- Chapter 17. Some exciting future directions for work on naked mole-rats (Smith ESJ, ParkTJ, Holmes MM and Buffenstein R).
Dr. Rochelle (Shelley) Buffenstein is a Senior Principal
Investigator at Calico Life Sciences LLC, a company dedicated to
harnessing advanced technologies to understand the basic biology of
aging. She is also an adjunct professor in the Department of
Pharmacology at the University of Texas Health Science Center at
San Antonio. Shelley has published more than 180 publications, and
has been recognized with several awards, including a Breakthroughs
in Gerontology award from the Glenn Foundation, an Ellison Medical
Foundation Senior scholar award, the ADPS Longevity Award and the
American Aging Association Denham Harman Lifetime Achievement
award. Shelley started off her career as an ecophysiologist
studying a diverse suite of species that inhabit extremely
challenging environments, undertaking her PhD under the mentorship
of Jenny Jarvis on the ecophysiology of desert rodents. While
a student at the University of Cape Town, she accompanied Jenny
Jarvis on various field trips to Kenya, Namibia and within South
Africa to undertake field work on mole-rats and other
rodents. A key focus of her research over the last 30 years
has been the physiology, endocrinology and aging biology of the
exceptionally long-lived (~35 years) naked mole-rat and the
molecular mechanisms these mouse-size rodents employ to maintain
good health, reproductive fitness and cognition well into their
third decade. Working with a species that hasn’t read the textbook
of how to behave like a mammal has been an incredibly rewarding
experience, forging terrific friendships through collaboration and
intriguing scientific challenges.
Thomas Park is a professor of Biological Sciences and Neuroscience
at the University of Illinois at Chicago. His graduate training was
in behavioral assessments of sound perception in birds and gerbils.
His post-doctoral training was in electrophysiology of auditory
brain regions in awake bats. After taking a position at the
University of Illinois at Chicago, he obtained a colony of naked
mole-rats from Professor Jenny Jarvis with the idea of studying
their hearing. But the naked mole-rats spoke to him and expanded
his research focus and his life. Now, in addition to hearing, he
focuses on amazing adaptations that naked mole-rats have for
tolerating oxygen deprivation and high concentrations of carbon
dioxide. Working with naked mole-rats has also opened the door for
wonderful collaborations and lifelong friendships.
Melissa Holmes is an associate professor of Psychology at the
University of Toronto Mississauga. Her doctoral training was in
sexual differentiation and adult plasticity in green anoles.
Working with Professor Nancy Forger, her post-doctoral training was
in sex and status effects on neural plasticity in naked mole-rats.
When starting her position at the University of Toronto, she
inherited a colony of naked mole-rats from Professor Bruce Goldman,
to continue their work on behavioral neuroendocrinology and adult
neural plasticity. She continues to use multi- and
inter-disciplinary approaches to primarily focus on the remarkable
social and reproductive adaptations in naked mole-rats as well as
contribute to a variety of diverse research questions through many
successful and rewarding collaborative projects.
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