Table of Contents

Preface Part I Basic Mechanisms 1. Repolarization: Historical PerspectivesBerndt Luderitz, MD and Thorsten Lewalter, MD 2. Physiology of Myocardial RepolarizationMichiel J. Janse, MD 3. Diversity of Ionic Channel Expression in Health and DiseaseStefan Kaab, MD and Michael Nabauer, MD 4. Electrophysiologic Mechanisms of Reentrant ArrhythmiasNabil El-Sherif, MD, Dmitry O. Kozhevnikov, MD, and Gioia Turitto, MD 5. Experimental Models to Assess the Role of Heterogeneous Repolarization in ArrhythmogenesisCharles Antzelevitch, PhD and Andrew Zygmunt, PhD 6. Repolarization and Mechanoelectrical Feedback: Evidence from Experimental and Clinical DataLars Eckardt, MD, Paulus Kirchhof, MD, Peter Loh, MD, Martin Borggrefe, MD, Gunter Breithardt, MD, and Wilhelm Haverkamp, MD 7. Repolarization Mapping Using Monophasic Action PotentialsPaulus F. Kirchhof, MD and Michael R. Franz, MD, PhD 8. Mechanisms and Clinical Aspects of Ventricular Arrhythmias Associated with QT Prolongation: Torsades de PointesWilhelm Haverkamp, MD, Gerold Monnig, Lars Eckardt, MD, Paulus Kirchhof, MD, Eric Schulze-Bahr, MD, Horst Wedekind, MD, Franziska Haverkamp, Martin Borggrefe, MD, and Gunter Breithardt, MD Part II The QT Interval 9. QT Dynamicity as a Predictor for Arrhythmia DevelopmentPhilippe Coumel, MD and Pierre Maison Blanche, MD 10. QT Dispersion: Definition, Methodology, and Clinical RelevanceVinzenz Hombach, MD, Hans-Heinrich Osterhues, MD, Birgit Schles, MD, Mathias Kochs, MD, Hans A. Kestler, PhD, and Martin Hoher, MD 11. Detection of T Wave Alternans and its Relationship to Cardiac ArrhythmogenesisMariah L. Walker, MSc and David S. Rosenbaum, MD 12. Microvolt-Level T Wave Alternans: Prognostic ImplicationsStefan H. Hohnloser, MD and Thomas Klingenheben, MD Part III Congenital Long QT Syndrome and Other Genetic Entities 13. Clinical Presentation of the Long QT Syndrome in the Era of Molecular DiagnosisPeter J. Schwartz, MD 14. Molecular Genetics of the Long QT SyndromeSilvia G. Priori, MD, PhD and Carlo Napolitano, MD, PhD 15. Congenital Long QT Syndrome: Genotype and Phenotype Correlations and TreatmentArthur J. Moss, MD, Wojciech Zareba, MD, PhD, and Jennifer L. Robinson, MS 16. Other Genetic Disorders and Primary Arrhythmias: The Brugada SyndromeJosep Brugada, MD, PhD, Pedro Brugada, MD, PhD, and Ramon Brugada, MD 17. Sudden Infant Death Syndrome: Is There a Genetic Basis?Horst Wedekind, MD, Eric Schulze-Bahr, MD, Wilhelm Haverkamp, MD, Thomas Bajanowski, MD, Bernd Brinkmann, MD, and Gunter Breithardt, MD Part IV Acquired Long QT Syndrome 18. Drugs and Myocardial RepolarizationMarc A. Vos, PhD and Harry J.G.M. Crijns, MD, PhD 19. Acquired Long QT Syndrome by Antiarrhythmic DrugsYee Guan Yap, BMedSci, MBBS, MRCP and A. John Camm, MD 20. The Acquired Long QT Syndrome by Non-antiarrhythmic DrugsDan M. Roden, MD 21. Genetic Aspects of Acquired Long QT SyndromeEric Schulze-Bahr, MD, Isabelle Denjoy, MD, Wilhelm Haverkamp, MD, and Pascale Guicheney, PhD 22. The Cytochrome P450 System as a Pathway for Drug-Drug InteractionS. Oguz Kayaalp, MD, PhD and Sule Oktay MD, PhD 23. How to Avoid Drug-Induced Torsades de PointesGunter Breithardt, MD, Martin Borggrefe, MD, Eric Schulze-Bahr, MD, and Wilhelm Haverkamp, MD Part V Various Clinical Conditions 24. Evidence of Repolarization Abnormalities in Various Clinical ConditionsKudret Aytemir, MD and Ali Oto, MD 25. Implantable Cardioverter Defibrillator Therapy in Patients with Repolarization AbnormalityHasan Garan, MD Index