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Toxicology Handbook


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Section 1: Introduction * Who are the authors * Scope of the book * Handbook of acute management of common poisonings. * Hands on and practical approach. * Rationale for drugs included * How to use the book * Universal disclaimer Clinical: Approach to the poisoned patient * Overview of approach to toxicology/toxinology * Principles of risk assessment-based approach * Resuscitation, Risk assessment, Supportive care, Decontamination, Investigations, Enhanced elimination, Antidotes, Disposition Section 2: Approach to specialist toxicology problems * Approach to special problems: Approach to snakebite, mushroom poisoning, plant poisoning * Toxidromes: Serotonin syndrome, Neuroleptic Malignant Syndrome, anticholinergic syndrome, cholinergic syndrome * Important poisoning manifestations and management: Seizures, coma, hypotension, delirium and agitation * Drugs of abuse and withdrawal syndromes: Alcohol, amphetamines, opiods, sedative hypnotics, body packers and stuffers * Investigations: Laboratory results: acidosis, anion gap and osmolar gap, recommended baseline investigations with interpretation. Unit conversion table: ECG interpretation in poisoning: Radiology. * Special populations: Paediatric poisoning: 1 tablet can kill (list), special precautions in management (overnight stay, paracetamol, risk of charcoal etc); Pregnancy and lactation and poisoning; and Geriatric poisoning Section 3: Toxic Drugs (78 chapters) * Approach to diagnosis, investigation and management of the poisoned patient with all of the common drug presentations. Updated with 8 new drug chapters as per readers nominations and feedback Section 4: Antidotes (29 chapters) * Detailed description of indications, contraindications, clinical administration and therapeutic end-points for all antidotes. New chapter on Intralipid, the latest development in antidote therapy Section 5: Toxinology (16 chapters) * Approach to snakebite, spider and marine envenoming. New chapter on tick envenoming Section 6: Antivenom (11 chapters) * Detailed description of indications, contraindications, clinical administration and therapeutic end-points for all antivenoms Appendices Sample ECGs from poisoned patients; Drug concentrations and unit conversion chart; Guide to the management of allergic reaction to antivenom

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