Table of Contents

Part 1: Basic Concepts in Cancer Genetics1. Introduction2. The Nature and Mechanisms of Human Cancer Mutation3. Genomic Imprinting and Cancer4. Genes Altered by Chromosomal Translocations in Leukemia and Lymphomas5. Chromosome Alterations in Human Solid Tumors6. Gene Amplification in Human Cancers: Biological and Clinical Significance 7. Tumor Genome Instability8. Gene Expression Profiling in CancerPart 2: Controls on Cell Cycle9. Cell Cycle Control: An Overview 10. Apoptosis and Cancer11. Oncogenes12. Tumor-Suppressor GenesPart 3: Familial Cancer Syndromes Section I. Overview 13. Familial Cancer Syndromes: Role of Caretakers and GatekeepersSection II. Defects in Caretakers14. Nucleotide Excision Repair Syndromes: Xeroderma Pigmentosum, Cockayne Syndrome, and Trichothiodystrophy15. Ataxia-Telangiectasia16. Bloom Syndrome 17. Fanconi Anemia18. Hereditary Nonpolyposis Colorectal Cancer (HNPCC)19. Werner Syndrome20. Peutz-Jeghers Syndrome21. Juvenile Polyposis SyndromeSection III. Defects in Gatekeepers 22. Retinoblastoma23. Li-Fraumeni Syndrome24. Wilms Tumor 25. Neurofibromatosis 126. Neurofibromatosis 227. Renal Carcinoma28. Multiple Endocrine Neoplasia Type 129. Multiple Endocrine Neoplasia Type 230. Malignant Melanoma31. Cowden Syndrome32. Skin Cancer (Including Nevoid Basal Cell Carcinoma Syndrome)33. Breast Cancer34. Colorectal Tumors35. Pilomatricoma and Pilomatrix Carcinoma36. Hereditary Paragangliomas of the Head and Neck37. Cylindromatosis38. Familial Cardiac Myxomas and Carney ComplexSection IV. Managing Familial Cancer Syndromes39. Genetic Testing for Familial CancerPart 4. Cancer by Site40. Pancreatic Cancer41. Ovarian Cancer42. Endometrial Cancer43. Cervical Cancer44. Bladder Cancer45. Stomach Cancer46. Prostate Cancer47. Brain Tumors48. Lung Cancer49. Hepatocellular Carcinoma50. Clinical and Biological Aspects of Neuroblastoma51. Cancers of the Oral Cavity and Pharynx52. Genetic Abnormalities in Lymphoid Mailgnancies

About the Author

Bert Vogelstein, MD, Investigator, Howard Hughes Medical Institute, Clayton Professor of Oncology and Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland



Kenneth W. Kinzler, PhD, Professor of Oncology, The Johns Hopkins University School of Medicine, Baltimore, Maryland