Table of Contents

SECTION I: GENERAL PRINCIPLES 1. Pharmacokinetics and Pharmacodynamics 2. Drug Transport/Drug Transporters 3. Drug Metabolism 4. Pharmacogenomics 5. Principles of Therapeutics SECTION II: DRUGS ACTING AT SYNAPTIC AND NEUROEFFECTOR JUNCTIONAL SITES 6. Neurotransmission: The Autonomic and Somatic Motor Nervous Systems 7. Muscarinic Receptor Agonists and Antagonists 8. Anticholinesterase Agents 9. Agents Acting at the Neuromuscular Junction and Autonomic Ganglia 10. Catecholamines, Sympathomimetic Drugs, and Adrenergic Receptor Antagonists 11. 5-Hydroxytryptamine (Serotonin) Receptor Agonists and Antagonists SECTION III: DRUGS ACTING ON THE CENTRAL NERVOUS SYSTEM 12. Neurotransmission and the Central Nervous System 13. History and Principles of Anesthesiology; General Anesthetics 14. Local Anesthetics 15. The Therapeutic Gases: Oxygen, Carbon Dioxide, Nitric Oxide, and Helium 16. Hypnotics and Sedatives 17. Introduction to Psychopharmacology: Drug Therapy of Depression and Anxiety Disorders 18. Pharmacotherapy of Psychosis and Mania 19. Drugs Effective in the Therapy of the Epilepsies 20. Treatment of Central Nervous System Degenerative Disorders 21. Opioid Analgesics 22. Ethanol 23. Drug Addiction and Drug Abuse SECTION IV: AUTACOIDS: DRUG THERAPY OF INFLAMMATION Introduction 24. Histamine, Bradykinin, and Their Antagonists 25. Lipid-Derived Autacoids: Eicosanoids and Platelet-Activating Factor 26. Analgesic-Antipyretic and Antiinflammatory Agents and Drugs Employed in the Treatment of Gout 27. Drugs Used in the Treatment of Asthma SECTION V: DRUGS AFFECTING RENAL AND CARDIOVASCULAR FUNCTION 28. Diuretics 29. Vasopressin and Other Agents Affecting the Renal Conservation of Water 30. Renin and Angiotensin 31. Drugs Used for the Treatment of Myocardial Ischemia 32. Antihypertensive Agents and the Drug Therapy of Hypertension 33. Pharmacological Treatment of Heart Failure 34. Antiarrhythmic Drugs 35. Drug Therapy for Hypercholesterolemia and Dyslipidemia SECTION VI: DRUGS AFFECTING GASTROINTESTINAL FUNCTION 36. Agents Used for Control of Gastric Acidity and Treatment of Peptic Ulcers and Gastroesopheageal Reflux Disease 37. Prokinetic Agents, Antiemetics, and Agents Used in Irritable Bowel Syndrome 38. Agents Used of Diarrhea, Constipation, and Inflammatory Bowel Disease; Agents Used for Biliary and Pancreatic Disease SECTION VII: CHEMOTHERAPY OF PARASITIC INFECTIONS 39. Drugs Used in the Chemotherapy of Protozoal Infections: Malaria 40. Drugs Used in the Chemotherapy of Protozoal Infections: Amebiasis, Giardiasis, Trichomoniasis, Trypanosomiasis, Leishmaniasis, and Other Protozoal Infections 41. Drugs Used in the Chemotherapy of Helminthiasis SECTION VIII: CHEMOTHERAPY OF MICROBIAL DISEASES 42. Antimicrobial Agents: General Considerations 43. Antimicrobial Agents (Continued): Sulfonamides, Trimethoprim-Sulfamethoxazole, Quinolones, and Agents for Urinary Tract Infections 44. Antimicrobial Agents: Penicillins, Cephalosporins, and Other b-Lactam Antibiotics 45. Antimicrobial Agents: The Aminoglycosides 46. Antimicrobial Agents: Protein-Synthesis Inhibitors and Miscellaneous Antibacterial Agents 47. Antimicrobial Agents (Continued): Drugs Used in the Chemotherapy of Tuberculosis, Mycobacterium avium Complex Disease, and Leprosy 48. Antimicrobial Agents: Antifungal Agents 49. Antimicrobial Agents: Antiviral Agents (Nonretroviral) 50. Antimicrobial Agents: Antiretroviral Agents SECTION IX: CHEMOTHERAPY OF NEOPLASTIC DISEASES Introduction 51. Antineoplastic Agents SECTION X: DRUGS USED FOR IMMUNOMODULATION 52. Imunomodulators: Immunosuppressive Agents, Tolerogens, and Immunostimulants SECTION XI: DRUGS ACTING ON THE BLOOD AND THE BLOOD-FORMING ORGANS 53. Hematopoietic Agents: Growth Factors, Minerals, and Vitamins 54. Blood Coagulation and Anticoagulant, Thrombolytic, and Antiplatelet Drugs SECTION XII: HORMONES AND HORMONE ANTAGONISTS 55. Pituitary Hormones and Their Hypothalamic Releasing Factors 56. Thyroid and Antithyroid Drugs 57. Estrogens and Progestins 58. Androgens 59. Adrenocorticotropic Hormone; Adrenocortical Steroids and Their Synthetic Analogs; Inhibitors of the Synthesis and Actions of Adrenocortical Hormones 60. Insulin, Oral Hypoglycemic Agents, and the Pharmacology of the Endocrine Pancreas 61. Agents Affecting Calcification and Bone Turnover: Calcium, Phosphate, Parathyroid Hormone, Vitamin D, Calcitonin, and Other Compounds SECTION XIII: DERMATOLOGY 62. Dermatological Pharmacology SECTION XIV: OPHTHALMOLOGY 63. Ocular Pharmacology SECTION XV: TOXICOLOGY 64. Principles of Toxicology; Treatment of Poisoning 65. Poisoning; Heavy Metals and Heavy-Metal Antagonists APPENDICES I. Principles of Prescription Order Writing and Patient Compliance II. Design and Optimization of Dosage Regimens; Pharmacokinetic Data

About the Author

Laurence L. Brunton, PhD
Professor of Pharmacology and Medicine
University of California, San DiegoLaurence Brunton trained under Alfred Goodman-Gilman and is nationally recognized for his expertise in cell signaling and cardivacular pharmacology. He has published more than 200 original research papers. John S. Lazo, PhD

Professor and Chairman

Department of Pharmacology

University of Pittsburgh School of Medicine

Under John Lazo's leadership as Chairman, the Department of Pharmacology is regarded as one of the leading academic programs in the United States. He has published extensively in the field of cancer pharmacology.
Keith Parker, MD, PhD
Professor of Internal Medicine and Pharmacology
Division of Endocrinology
Department of Internal Medicine
University of Texas Southwestern School of Medicine

Reviews

"There are few technical books that remain in a leadership position for 65 years. The Pharmacological Basis of Therapeutics is one. Physicians, teachers, and medical students have voted for Goodman & Gilman with their feet and with their pocketbooks for over six decades. The question is not whether this is an important and useful text, but why?...While Goodman & Gilman is no quick-read, it is surprisingly clearly written, logical and interesting. It is also an awesome realization to see how much one never knew, added to what one knew but forgot."--The Permanente Journal The Permanente Journal 20060801