Global Burden of Disease. Immunology. Trial Design for Vaccines. Ethics and Vaccines. Understanding Microbial Pathogenesis as a Basis for Vaccine Design. Disease States and Vaccines: Selected Cases. Economics of Vaccines: From Vaccine Candidate to Commercialized Product. Vaccine Safety: Real and Perceived Issues. Introduction to New Vaccines in the Healthcare System. Future Challenges for Vaccines and Immunizations.
Topics unique to this book:
* Ethics
* Economics
* Diseases that could be prevented
* Clinical trial designs
* Ideas about the future of vaccines
* Challenges facing research scientists in the vaccine area
* Burden of vaccine-preventable illness and the impact of
vaccines
* Scientific obstacles to be overcome by existing and new
vaccines
* Basic mechanisms of host immunity and pathogen interaction with
host tissues
* New approaches to future vaccines against challenging
diseases
* Real and perceived safety issues which dominate vaccine
development and vaccination policies
* Microbial pathogenesis as a basis for vaccine design
* Planning vaccine trials
* Introducing new vaccines into the healthcare system
* Future challenges for vaccines and immunizations
Dr. Bloom is Harvard University's Distinguished Service Professor
of the Department of Immunology and Infectious Diseases and Former
Dean of the Harvard School of Public Health. He received a
bachelor’s degree and an honorary Sc.D. from Amherst College, and a
Ph.D. from Rockefeller University. He is widely recognized for his
work in the area of cell-mediated immunity, infectious diseases,
particularly tuberculosis and leprosy, and global health. The
discovery of lymphocyte-produced cytokines and the development of
genetic systems in mycobacteria are among his scientific
contributions. He has published over 300 papers and edited 4 books.
He served as a consultant to the White House on International
Health Policy, was elected President of the American Association of
Immunologists, and served as President of the Federation of
American Societies for Experimental Biology.
Dr. Bloom has been extensively involved with the World Health
Organization (WHO) for more than 40 years. He was a member of the
WHO Advisory Committee on Health Research (ACHR) and chaired the
WHO Committees on Immunology of Leprosy (IMMLEP), Immunology of
Tuberculosis (IMMTUB), the Scientific and Technical Advisory
Committee of the UNDP/World Bank/WHO Special Programme for Research
and Training in Tropical Diseases (STAC) and chaired the WHO Global
Malaria Programme. He was first chair of the Board of Trustees of
the International Vaccine Institute, Seoul, Korea. He as served on
the National Advisory Councils of the U.S. National Institute of
Allergy and Infectious Diseases, NIH, and the Center for Infectious
Diseases, of the US Centers for Disease Control and Prevention. He
currently serves on the scientific advisory boards of the Wellcome
Trust Centre for Human Genetics, K-RITH, and Human Heredity and
Health in Africa (H3Africa). He has received numerous awards for
his scientific work including the first Bristol-Myers Award in
Infectious Diseases, the Robert Koch Gold Medal for lifetime
achievement in research, and shared the Novartis Award in
Immunology. He was elected to membership of the U.S. National
Academy of Sciences, the National Academy of Medicine, the American
Academy of Arts and Sciences and the American Philosophical
Society.
Paul-Henri Lambert, MD, is now associated with the Centre of
Vaccinology in the Department of Pathology and Immunology at
University of Geneva. He is particularly interested in vaccination
strategies and evaluation of adverse effects. He is directing the
International Advanced Course of Vaccinology (ADVAC) organized
under the auspices of the Fondation Mérieux and University of
Geneva. He is a member of the Governing Board of the Tuberculosis
Vaccine Initiative (TBVI) and past-chairman of the Human Vaccine
Committee of the International Association for Biologicals (IABS)
and of the WHO GACVS (Global Advisory Committee on Vaccine Safety).
Paul Henri Lambert is a native of Belgium where he was boarded in
Internal Medicine (University of Liege). He joined Frank Dixon at
Scripps Institute, La Jolla, California, for his training then
moved to University of Geneva Medical School where he became
professor in the Departments of Medicine and of Pathology. His
research activities lead him to decipher immunological mechanisms
involved in autoimmune and immune complex-mediated diseases, in the
pathogenesis of malaria and in new strategies to optimize vaccine
immunogenicity. In 1987, he was appointed as chief Microbiology and
Immunology at the World Health Organization and in 1994, Chief,
Vaccine Research and Development, WHO Global Program for Vaccines
and Immunization. He was then deeply involved in co-ordination of
research aiming at the development of vaccines against diseases of
major importance in developing countries. Paul-Henri Lambert is
author or co-author of 436 publications, member of several
international scientific boards, foreign member of the Royal
Academy of Medicine in Belgium and Fellow of the American
Association for the Advancement of Science.
"This comprehensive book, consisting of 10 chapters written by leading experts in almost all facets of the vaccine research and development enterprise, should be a standard reference work for anyone from student to senior professional interested in the current challenges in and prospects for the science of vaccines." --Richard T. Mahoney, Bulletin of the World Health Organization, September 2004) "...This comprehensive book, consisting of 10 chapters written by leading experts in almost all facets of the vaccine research and development enterprise, should be a standard reference work for anyone from student to senior professional interested in the current challenges in and propsects for the science of vaccines." --BULLETIN OF THE WORLD HEALTH ORGANIZATION (2004) "...provides a thorough review on a wide variety of topics regarding vaccines and immunization. ...recommended for academic health science libraries and corporate libraries interested in vaccine development. Individual researchers studying vaccines, students, and public health officials may also benefit from the information found in this book." --E-STREAMS (2003) "...a useful reference book. ...should appeal to a wide audience, including health economists and strategists, microbiologists and epidemiologists." --MICROBIOLOGY TODAY (2003)
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