Chapter 1: The Anatomy and Molecular Architecture of the
Neuromuscular, Andrew G. Engel, MD
Chapter 2: Electrodiagnosis of Myasthenic Disorders, C. Michel
Harper, MD
Chapter 3: The Immunopathogenesis of Myasthenia Gravis, Reinhard
Hohlfeld, Hartmut Wekerle, and Alexander Marx
Chapter 4: Natural History of Myasthenia Gravis, Vladimir Luchanok,
MD, PhD, and Henry J. Kaminski, MD
Chapter 5: The Diagnosis of Myasthenia Gravis and Other Disorders
of Neuromuscular Transmission, James F. Howard, JR., M.D.
Chapter 6: Therapy of Myasthenia Gravis, Daniel B. Drachman,
M.D.
Chapter 7: The Lambert-Eaton Myasthenic Syndrome, Vern C. Juel,
M.D., and Donald B. Sanders, M.D.
Chapter 8: Congenital Myasthenic Syndromes, Andrew G. Engel, M.D.,
Xin-Ming Shen, Ph.D., Kinji Ohno, M.D., Ph.D, Steven M. Sine,
Ph.D.
Chapter 9: End-Plate Acetylcholine Receptor, a Target for
Myasthenic Disorders: Structural and Mechanistic Essentials, Steven
M. Sine and Andrew G. Engel
Chapter 10: Peripheral Nerve Hyperexcitability Syndromes, Srikanth
Muppidi, M.D. and Steven Vernino, M.D., Ph.D.
Chapter 11: Effects of Antiganglioside Antibodies at the
Neuromuscular Junction, Jaap J. Plomp and Hugh J. Willison
Dr. Andrew Engel is the McKnight-3M Professor of Neuroscience and
Professor of Neurology, Mayo Clinic College of Medicine as well as
the Director of the Neuromuscular Disease laboratory at the Mayo
Clinic, Rochester, MN campus. He earned his medical degree at
McGill University, was trained in Neurology at the NIH and the Mayo
Clinic and in Neuropathology at Columbia University and has spent
his entire professional carrier at the Mayo Clinic. Dr
Engel has had a longstanding interest in neuromuscular diseases and
especially those affecting neuromuscular transmission.
"Dr. Engel is a consummate investigator and master of the multiple
sciences involved in understanding the causes and pathogenesis of
myasthenia gravis and related syndromes. As editor of this
encyclopedic book, he has gathered a stellar group of co-authors to
cover every conceivable aspect of these diseases. The discussions
will help students, clinicians and scientists who seek the details
they need to understand the diseases and to deliver the best
possible
treatments. These diseases are among the best understood human
autoimmune conditions. The antigens and antibodies are known, the
immune system has been dissected, and treatment has improved to
the
point that almost no one now dies of what was once a lethal
disease." -- Lewis P. Rowland MD, Columbia University Medical
Center, New York, NY
"The second edition of Engel's Myasthenia Gravis and Myasthenic
Disorders will be warmly welcomed by neurologists and the
neuromuscular fraternity. This magnum opus is a masterwork,
beautifully orchestrated by Andrew Engel, and covering the whole
range of major advances in recent years. In addition to his own
contribution in several chapters, he has assembled an impressive
array of experts in the field and covered topics ranging from
anatomy and
molecular architecture of the neuromuscular junction in his own
opening chapter, through diagnostic techniques and special chapters
on Congenital Myasthenic Syndromes and Lambert-Eaton syndrome, to
advances in
therapy. It should continue to maintain its position as a
pre-eminent guide and reference for this important field." --
Victor Dubowitz, Neuromuscular Disorders
"Comprehensively written, meticulously referenced, and beautifully
illustrated, this book will be appreciated by both adult and
pediatric neuromuscular specialists as well as scientists engaged
in basic, translational, and clinical investigation of the
neuromuscular junction, myasthenia gravis, and related disorders."
-- Michael Benatar, Neurology
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